The domain within your query sequence starts at position 300 and ends at position 382; the E-value for the RPT_2 domain shown below is 1.54e-5.

QWIRHHTAAFEERKFPSSFEEIEILWCQFLKFKETELPAKEADKNRSKVIYQSLEGAVQA
GQLKIPPGYHPLDVEKEWGKLHV

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.