The domain within your query sequence starts at position 356 and ends at position 466; the E-value for the RPT_2 domain shown below is 2.78e-10.

PANLSSQSLMASLSTQVLQYKQPSFHISQSYDLISEYFLSENIPFQDNQSQDTPSQYTPS
QDIQFQDMLAQDISFQEIQSQESPNQDVLYQETPPQETPSQGTPYQDLPYQ

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.