The domain within your query sequence starts at position 387 and ends at position 461; the E-value for the RPT_2 domain shown below is 2.31e-5.

LVESTSEEAPCGSGVAETPLSTDVPERDMGPSKEGSAPPEGDPAFSERHMAFPGGGSIPP
EGNTTPHKGVMEPPE

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.