The domain within your query sequence starts at position 4106 and ends at position 4251; the E-value for the RPT_2 domain shown below is 6.03e-7.

FLLVGKTTDPLISLDKSHLNFSSLLIGREARETVKIINKEEQGFNFAFQDNSRYSEGFNN
SLIVCPMEGWIPPLSRFPVDIFFTPKQEGDVNFNLICNIKKKAHPLTLNVKAEGYTMNAE
VKCRDRMGTTILLTSTQVNTINFYEV

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.