The domain within your query sequence starts at position 417 and ends at position 510; the E-value for the RPT_2 domain shown below is 1.08e-6.

CSRPCEFRLACGHVCTRACHPYDSSHKEFQCMKPCQKVLCQDGHRCPNVCFQECQPCQVK
VPKIILKCGHKQMVPCSMSESEFCCQEPCSKILR

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.