The domain within your query sequence starts at position 428 and ends at position 581; the E-value for the RPT_2 domain shown below is 1.74e-6.

EKPVPNSEEKWKARVDEIEDAIYVTMEILSNWGNASWVGLTEVQFFDLNNIKLYVSPHDV
DIRNAVLPGELGCLVNRDLVSKKDPPVWTCPFHPPLQLYFIIHNMRQLRDFGLTMIKVRN
YWTADGDLDIGAKNVKLYVNKSLIFDGVLEKGGG

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.