The domain within your query sequence starts at position 436 and ends at position 518; the E-value for the RPT_2 domain shown below is 2.42e-5.

QWIRHHTAAFEERKFPSSFEEIEILWCQFLKFKETELPAKEADKNRSKVIYQSLEGAVQA
GQLKIPPGYHPLDVEKEWGKLHV

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.