The domain within your query sequence starts at position 461 and ends at position 595; the E-value for the RPT_2 domain shown below is 1.38e-5.

PGIPPYGTLPPGRMAHASMGNRPYGPNMANMPPQVGSGMCPPPGGMNRKTQESAVAMHVA
ANSIQNRPPGYPNMNQGGMMGTGPPYGQGINSMAGMINPQGPPYPMGGTMANNSAGMAAS
PEMMGLGDVKLTPAT

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.