The domain within your query sequence starts at position 493 and ends at position 744; the E-value for the RPT_2 domain shown below is 2.83e-6.
EQQLLRRFWFVWHQQAAVCQLERQQQAMAIAHHHSGLLRRAFCIWKESTQGFRIERMGRA
QAAHFHSAQLLSRAWSMWRECLALRLEEQQKLKCAALHSQCILLRRALQKWLVYQNRVRS
VLREVAARERQHNRQLLWWALHLWRENTMARLDGAKKTSQARVHYSRTLCSKVLVQWREV
TSVQIYYRQKEAAALREARKALDRGRLQNWFQHWRFCSQRAAQQRFQLGQAAQHHHWQLL
MEAMARWKAHHL
This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.