The domain within your query sequence starts at position 4403 and ends at position 4689; the E-value for the RPT_3 domain shown below is 2.05e-6.

PGKTLEIPITFYPREAISYRELIPFEINGLSQQTVEIKGKGTEMKLLVLDPANRIVKLGA
VLPGQVVRKTVSLVNNSLAQLTFNHSVLFSIPELQEAKVITLEPFHTITMKPKEVCKLEI
TFAPKKRVPPFSEEVFMEWMGLLRPLFLLSGCCQALEISLDQEHLPFGPVVYQTQATRRI
LIMNTGDVGARFKWDVKKLKPHFSISPEEGYIISGTEVALEVTYHPTEIGKESLYKNILC
FIQGGNPLCLTLSGTCVGPPVVKEVVNFNCQVRSRHTQTILLSNRSN

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.