The domain within your query sequence starts at position 3222 and ends at position 3280; the E-value for the RPT_4 domain shown below is 2.96e-13.

SSQYGQYRCPSSHYSSQSQHGVGCSHGFNTGQYGSGSYPSSNSRQNCPGSGLCPTSEQY

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.