The domain within your query sequence starts at position 357 and ends at position 431; the E-value for the RPT_4 domain shown below is 3.12e-6.

LYGNKGVDGRDSDLLVDGDLGEYDFYEYKEYEERTTTSPNEEFGPGVPAETDFTETSING
HGAYGEKGQKGEPAV

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.