The domain within your query sequence starts at position 4317 and ends at position 4532; the E-value for the RPT_4 domain shown below is 5.14e-6.

KGLELKIKISHGPTFVCNILGCAVSPAVHFSFTSHNFGTCFIYQAGMPPYKQILVVTNKE
ETSMSLDCLYTNTPHIEVNFNVDVIKPGKTLEIPITFYPREAISYRELIPFEINGLSQQT
VEIKGKGTEMKLLVLDPANRIVKLGAVLPGQVVRKTVSLVNNSLAQLTFNHSVLFSIPEL
QEAKVITLEPFHTITMKPKEVCKLEITFAPKKRVPP

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.