The domain within your query sequence starts at position 4046 and ends at position 4190; the E-value for the RPT_5 domain shown below is 3.23e-5.

WTSEETESLQHPPAFVCLTEKGIIHPEKKAEIIFQFLPAHLDITEEFWTFSIPEHNISVP
FLLVGKTTDPLISLDKSHLNFSSLLIGREARETVKIINKEEQGFNFAFQDNSRYSEGFNN
SLIVCPMEGWIPPLSRFPVDIFFTP

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.