DIRP (Domain in Rb-related Pathway) is postulated to be involved in the Rb-related pathway, which is encoded by multiple eukaryotic genomes and is present in proteins including lin-9 of Caenorhabditis elegans, aly of fruit fly and mustard weed. Studies of lin-9 and aly of fruit fly proteins containing DIRP suggest that this domain might be involved in development. Aly, lin-9, act in parallel to, or downstream of, activation of MAPK by the RTK-Ras signalling pathway.
DIRP (Domain in Rb-related Pathway) is postulated to be involved in the Rb-related pathway, which is encoded by multiple eukaryotic genomes and is present in proteins including lin-9 of Caenorhabditis elegans, aly of fruit fly and mustard weed. Studies of lin-9 and aly of fruit fly proteins containing DIRP suggest that this domain might be involved in development. Aly, lin-9, act in parallel to, or downstream of, activation of MAPK by the RTK-Ras signalling pathway [ (PUBMED:11076766) ].
Family alignment:
There are 1221 DIRP domains in 1219 proteins in SMART's nrdb database.
Click on the following links for more information.
Evolution (species in which this domain is found)
Taxonomic distribution of proteins containing DIRP domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with DIRP domain is also avaliable.
Click on the protein counts, or double click on taxonomic names to display all proteins containing DIRP domain in the selected taxonomic class.
Literature (relevant references for this domain)
Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
Transcription of meiotic cell cycle and terminal differentiation genes depends ona conserved chromatin associated protein, whose nuclear localisation isregulated.
Development. 2000; 127: 5463-73
Display abstract
The Drosophila always early (aly) gene coordinately regulates meiotic cell cycle progression and terminal differentiation during male gametogenesis. aly isrequired for transcription of key G2-M cell cycle control genes and of spermatid differentiation genes, and for maintenance of normal chromatin structure inprimary spermatocytes. We show that aly encodes a homologue of the Caenorhabditiselegans gene lin-9, a negative regulator of vulval development that acts in thesame SynMuvB genetic pathway as the LIN-35 Rb-like protein. The aly gene familyis conserved from plants to humans. Aly protein is both cytoplasmic and nuclearin early primary spermatocytes, then resolves to a chromatin-associated pattern. It remains cytoplasmic in a loss-of-function missense allele, suggesting thatnuclear localisation is critical for Aly function, and that other factors mayalter Aly activity by controlling its subcellular localisation. MAPK activationoccurs normally in aly mutant testes. Therefore aly, and by inference lin-9, act in parallel to, or downstream of, activation of MAPK by the RTK-Ras signallingpathway. We favour a model where aly may regulate cell cycle progression andterminal differentiation during male gametogenesis by regulating chromatinconformation in primary spermatocytes.
Links (links to other resources describing this domain)
