The domain within your query sequence starts at position 60 and ends at position 160; the E-value for the SPEC domain shown below is 2.54e-6.
HRLSRELDDVIERLREKESLIWAPEGTEDLENVQRLSWRQKVLQQEMGLIQTQVESLEGR IGRLCKESPEVAHSLRHKQQEMMDSWWKVWSKAQKWRELLD
SPECSpectrin repeats |
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SMART accession number: | SM00150 |
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Description: | - |
Interpro abstract (IPR018159): | Spectrin repeats [ (PUBMED:8266097) ] are found in several proteins involved in cytoskeletal structure. These include spectrin alpha and beta subunits [ (PUBMED:12672815) (PUBMED:15062087) ], alpha-actinin [ (PUBMED:10481917) ] and dystrophin. The spectrin repeat forms a three-helix bundle. The second helix is interrupted by proline in some sequences. The repeats are defined by a characteristic tryptophan (W) residue at position 17 in helix A and a leucine (L) at 2 residues from the carboxyl end of helix C. |
Family alignment: |
There are 257395 SPEC domains in 23741 proteins in SMART's nrdb database.
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- Evolution (species in which this domain is found)
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- Disease (disease genes where sequence variants are found in this domain)
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