The domain within your query sequence starts at position 550 and ends at position 642; the E-value for the TAFH domain shown below is 4.9e-54.



TAF homology
SMART accession number:SM00549
Description: Domain in Drosophila nervy, CBFA2T1, human TAF105, human TAF130, and Drosophila TAF110. Also known as nervy homology region 1 (NHR1).
Interpro abstract (IPR003894):

The TAF homology (TAFH) or Nervy homology region 1 (NHR1) domain is a domain of 95-100 amino acids present in eukaryotic proteins of the MTG/ETO family and whereof the core ~75-80 residues occur in TAF proteins. The transcription initiation TFIID complex is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). The TAFH/NHR1 domain is named after fruit fly TATA-box-associated factor 110 (TAF110), human TAF105 and TAF130, and the fruit fly protein Nervy, which is a homologue of human MTG8/ETO [ (PUBMED:9447981) (PUBMED:9790752) ]. The human eight twenty-one (ETO, MTG8 or CBFA2T1) and related myeloid transforming gene products MTGR1 and MTG16 as well as the Nervy protein contain the NHR1-4 domains. The NHR1/TAFH domain occurs in the N-terminal part of these proteins, while a MYND-type zinc finger forms the NHR4 domain [ (PUBMED:12559562) ]. The TAFH/NHR1 domain can be involved in protein-protein interactions, e.g in MTG8/ETO with HSP90 and Gfi-1 [ (PUBMED:10076566) ].

GO process:transcription, DNA-templated (GO:0006351)
Family alignment:
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There are 2238 TAFH domains in 2237 proteins in SMART's nrdb database.

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