The domain within your query sequence starts at position 143 and ends at position 279; the E-value for the TNF domain shown below is 2.29e-54.
SVAHLTGNPHSRSIPLEWEDTYGTALISGVKYKKGGLVINETGLYFVYSKVYFRGQSCNN QPLNHKVYMRNSKYPEDLVLMEEKRLNYCTTGQIWAHSSYLGAVFNLTSADHLYVNISQL SLINFEESKTFFGLYKL
TNFTumour necrosis factor family. |
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SMART accession number: | SM00207 |
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Description: | Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor. |
Interpro abstract (IPR006052): | Cytokines can be grouped into a family on the basis of sequence, functional and structural similarities [ (PUBMED:8095800) (PUBMED:1377364) (PUBMED:15335677) ]. Tumor necrosis factor (TNF) (also known as TNF-alpha or cachectin) is a monocyte-derived cytotoxin that has been implicated in tumour regression, septic shock and cachexia [ (PUBMED:2989794) (PUBMED:3349526) ]. The protein is synthesised as a prohormone with an unusually long and atypical signal sequence, which is absent from the mature secreted cytokine [ (PUBMED:2268312) ]. A short hydrophobic stretch of amino acids serves to anchor the prohormone in lipid bilayers [ (PUBMED:2777790) ]. Both the mature protein and a partially-processed form of the hormone are secreted after cleavage of the propeptide [ (PUBMED:2777790) ]. There are a number of different families of TNF, but all these cytokines seem to form homotrimeric (or heterotrimeric in the case of LT-alpha/beta) complexes that are recognised by their specific receptors. The following cytokines can be grouped into a family on the basis of sequence, functional, and structural similarities [ (PUBMED:8095800) (PUBMED:1377364) (PUBMED:15335677) ]:
All these cytokines seem to form homotrimeric (or heterotrimeric in the case of LT-alpha/beta) complexes that are recognised by their specific receptors. The PROSITE pattern for this family is located in a beta-strand in the central section of the protein which is conserved across all members. |
GO process: | immune response (GO:0006955) |
GO component: | membrane (GO:0016020) |
GO function: | tumor necrosis factor receptor binding (GO:0005164) |
Family alignment: |
There are 5212 TNF domains in 5186 proteins in SMART's nrdb database.
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