The domain within your query sequence starts at position 43 and ends at position 80; the E-value for the TNFR domain shown below is 5.73e-5.
CWDQDKEYYEPMHDVCCSRCPPGEFVFAVCSRSQDTVC
TNFRTumor necrosis factor receptor / nerve growth factor receptor repeats. |
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SMART accession number: | SM00208 |
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Description: | Repeats in growth factor receptors that are involved in growth factor binding. TNF/TNFR |
Interpro abstract (IPR001368): | A number of proteins, some of which are known to be receptors for growth factors, have been found to contain a cysteine-rich domain of about 110 to 160 amino acids in their N-terminal part, that can be subdivided into four (or in some cases, three) modules of about 40 residues containing 6 conserved cysteines. Some of the proteins containing this domain are listed below [ (PUBMED:2174582) (PUBMED:15335933) (PUBMED:15335677) ]:
It has been shown [ (PUBMED:8387891) ] that the six cysteines all involved in intrachain disulphide bonds. A schematic representation of the structure of the 40 residue module of these receptors is shown below:
'C': conserved cysteine involved in a disulphide bond. |
GO function: | protein binding (GO:0005515) |
Family alignment: |
There are 32859 TNFR domains in 11619 proteins in SMART's nrdb database.
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- Evolution (species in which this domain is found)
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- Structure (3D structures containing this domain)
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