The domain within your query sequence starts at position 480 and ends at position 500; the E-value for the UIM domain shown below is 2.98e2.
DEDYEIMQFAIQQSLLESSRS
UIMUbiquitin-interacting motif. |
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SMART accession number: | SM00726 |
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Description: | Present in proteasome subunit S5a and other ubiquitin-associated proteins. |
Interpro abstract (IPR003903): | The Ubiquitin Interacting Motif (UIM), or 'LALAL-motif', is a stretch of about 20 amino acid residues, which was first described in the 26S proteasome subunit PSD4/RPN-10 that is known to recognise ubiquitin [ (PUBMED:9488668) (PUBMED:11406394) ]. In addition, the UIM is found, often in tandem or triplet arrays, in a variety of proteins either involved in ubiquitination and ubiquitin metabolism, or known to interact with ubiquitin-like modifiers. Among the UIM proteins are two different subgroups of the UBP (ubiquitin carboxy-terminal hydrolase) family of deubiquitinating enzymes, one F-box protein, one family of HECT-containing ubiquitin-ligases (E3s) from plants, and several proteins containing ubiquitin-associated UBA and/or UBX domains [ (PUBMED:12062168) ]. In most of these proteins, the UIM occurs in multiple copies and in association with other domains such as UBA ( IPR015940 ), UBX ( IPR001012 ), ENTH, EH ( IPR000261 ), VHS ( IPR002014 ), SH3 ( IPR001452 ), HECT ( IPR000569 ), VWFA ( IPR002035 ), EF-hand calcium-binding, WD-40 ( IPR001680 ), F-box ( IPR001810 ), LIM ( IPR001781 ), protein kinase ( IPR000719 ), ankyrin ( IPR002110 ), PX ( IPR001683 ), phosphatidylinositol 3- and 4-kinase ( IPR000403 ), C2 ( IPR000008 ), OTU ( IPR003323 ), dnaJ ( IPR001623 ), RING-finger ( IPR001841 ) or FYVE-finger ( IPR017455 ). UIMs have been shown to bind ubiquitin and to serve as a specific targeting signal important for monoubiquitination. Thus, UIMs may have several functions in ubiquitin metabolism each of which may require different numbers of UIMs [ (PUBMED:12121618) (PUBMED:11919614) (PUBMED:1919637) ]. The UIM is unlikely to form an independent folding domain. Instead, based on the spacing of the conserved residues, the motif probably forms a short alpha-helix that can be embedded into different protein folds [ (PUBMED:11406394) ]. Some proteins known to contain an UIM are listed below:
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Family alignment: |
There are 36345 UIM domains in 18985 proteins in SMART's nrdb database.
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- Evolution (species in which this domain is found)
- Cellular role (predicted cellular role)
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- Metabolism (metabolic pathways involving proteins which contain this domain)
- Structure (3D structures containing this domain)
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