The domain within your query sequence starts at position 679 and ends at position 696; the E-value for the WH2 domain shown below is 4.82e-3.
DNSELLAEIKAGKSLKPT
WH2Wiskott Aldrich syndrome homology region 2 |
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SMART accession number: | SM00246 |
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Description: | Wiskott Aldrich syndrome homology region 2 / actin-binding motif |
Interpro abstract (IPR003124): | The WH2 (WASP-Homology 2, or Wiskott-Aldrich homology 2) domain is an ~18 amino acids actin-binding motif. This domain was first recognised as an essential element for the regulation of the cytoskeleton by the mammalian Wiskott-Aldrich syndrome protein (WASP) family. WH2 proteins occur in eukaryotes from yeast to mammals, in insect viruses, and in some bacteria. The WH2 domain is found as a modular part of larger proteins; it can be associated with the WH1 or EVH1 domain IPR000697 and with the CRIB domain IPR000095 and the WH2 domain can occur as a tandem repeat. The WH2 domain binds actin monomers and can facilitate the assembly of actin monomers into newly forming actin filaments [ (PUBMED:11434350) (PUBMED:11911886) ]. Some proteins known to contain a WH2 domain:
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GO function: | actin binding (GO:0003779) |
Family alignment: |
There are 10371 WH2 domains in 7489 proteins in SMART's nrdb database.
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- Evolution (species in which this domain is found)
- Cellular role (predicted cellular role)
- Metabolism (metabolic pathways involving proteins which contain this domain)
- Structure (3D structures containing this domain)
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