The domain within your query sequence starts at position 107 and ends at position 182; the E-value for the WWE domain shown below is 6.98e-26.



Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis.
SMART accession number:SM00678
Description: -
Interpro abstract (IPR018123):

The WWE domain is named after three of its conserved residues and is predicted to mediate specific protein-protein interactions in ubiquitin and ADP ribose conjugation systems. This domain is found as a tandem repeat at the N-terminal of Deltex, a cytosolic effector of Notch signalling thought to bind the N-terminal of the Notch receptor [ (PUBMED:16271883) ]. It is also found as an interaction module in protein ubiquination and ADP ribosylation proteins [ (PUBMED:11343911) ].

GO function:zinc ion binding (GO:0008270)
Family alignment:
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There are 2787 WWE domains in 1595 proteins in SMART's nrdb database.

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