The WWE domain is named after three of its conserved residues and is predicted to mediate specific protein-protein interactions in ubiquitin and ADP ribose conjugation systems. This domain is found as a tandem repeat at the N-terminal of Deltex, a cytosolic effector of Notch signalling thought to bind the N-terminal of the Notch receptor [ (PUBMED:16271883) ]. It is also found as an interaction module in protein ubiquination and ADP ribosylation proteins [ (PUBMED:11343911) ].
The WWE domain: a common interaction module in protein ubiquitination andADP ribosylation.
Trends Biochem Sci. 2001; 26: 273-5
Display abstract
Sequence profile analysis was used to detect a conserved globular domainin several proteins including deltex, Trip12 and poly-ADP-ribosepolymerase homologs. It was named the WWE domain after its most conservedresidues and is predicted to mediate specific protein-protein interactionsin ubiquitin and ADP-ribose conjugation systems.
Metabolism (metabolic pathways involving proteins which contain this domain)
This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with WWE domain which could be assigned to a KEGG orthologous group, and not all proteins containing WWE domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.
