The domain within your query sequence starts at position 83 and ends at position 222; the E-value for the ZnMc domain shown below is 1.16e-41.
All catalytic sites are present in this domain. Check the literature (PubMed 96311273 ) for details.
PSSRWKLPIPYILADNLELNAKGAILHAFEMFRLKSCVDFKPYEGESSYIIFQKLSGCWS MIGDQQVGQNISIGEGCDFKATIEHEILHALGFFHEQSRTDRDDYVNIWWDQIITDYEHN FNTYDDNTITDLNTPYDYES
ZnMcZinc-dependent metalloprotease |
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SMART accession number: | SM00235 |
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Description: | Neutral zinc metallopeptidases. This alignment represents a subset of known subfamilies. Highest similarity occurs in the HExxH zinc-binding site/ active site. |
Interpro abstract (IPR006026): | Over 70 metallopeptidase families have been identified to date. In these enzymes a divalent cation which is usually zinc, but may be cobalt, manganese or copper, activates the water molecule. The metal ion is held in place by amino acid ligands, usually three in number. In some families of co-catalytic metallopeptidases, two metal ions are observed in crystal structures ligated by five amino acids, with one amino acid ligating both metal ions. The known metal ligands are His, Glu, Asp or Lys. At least one other residue is required for catalysis, which may play an electrophillic role. Many metalloproteases contain an HEXXH motif, which has been shown in crystallographic studies to form part of the metal-binding site [ (PUBMED:7674922) ]. The HEXXH motif is relatively common, but can be more stringently defined for metalloproteases as 'abXHEbbHbc', where 'a' is most often valine or threonine and forms part of the S1' subsite in thermolysin and neprilysin, 'b' is an uncharged residue, and 'c' a hydrophobic residue. Proline is never found in this site, possibly because it would break the helical structure adopted by this motif in metalloproteases [ (PUBMED:7674922) ]. The majority of zinc-dependent metallopeptidases (with the notable exception of the carboxypeptidases) share a common pattern of primary structure [ (PUBMED:2914602) (PUBMED:1894005) ] in the part of their sequence involved in the binding of zinc, and can be grouped together as a superfamily,known as the metzincins, on the basis of this sequence similarity. They can be classified into around 40 distinct families [ (PUBMED:7674922) ]. This signature defines the metallopeptidases associated with MEROPS peptidase families: M7, M8, M10 (subfamilies A, B and C) and M12 (subfamily A) all of which are members of clan MA(M). |
GO process: | proteolysis (GO:0006508) |
GO function: | zinc ion binding (GO:0008270), metallopeptidase activity (GO:0008237) |
Family alignment: |
There are 34425 ZnMc domains in 34168 proteins in SMART's nrdb database.
Click on the following links for more information.
- Evolution (species in which this domain is found)
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Taxonomic distribution of proteins containing ZnMc domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with ZnMc domain is also avaliable.
Click on the protein counts, or double click on taxonomic names to display all proteins containing ZnMc domain in the selected taxonomic class.
- Cellular role (predicted cellular role)
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Binding / catalysis: Peptidase; zinc-binding
- Literature (relevant references for this domain)
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Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
- Gooley PR et al.
- The NMR structure of the inhibited catalytic domain of human stromelysin-1.
- Nat Struct Biol. 1994; 1: 111-8
- Display abstract
The three-dimensional structure of the catalytic domain of stromelysin-1 complexed with an N-carboxyl alkyl inhibitor has been determined by NMR methods. The global fold consists of three helices, a five stranded beta-sheet and a methionine located in a turn near the catalytic histidines, classifying stromelysin-1 as a metzincin. Stromelysin-1 is unique in having two independent zinc binding sites: a catalytic site and a structural site. The inhibitor binds in an extended conformation. The S1' subsite is a deep hydrophobic pocket, whereas S2' appears shallow and S3' open.
- Metabolism (metabolic pathways involving proteins which contain this domain)
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Click the image to view the interactive version of the map in iPath% proteins involved KEGG pathway ID Description 31.46 map05219 Bladder cancer 22.47 map04670 Leukocyte transendothelial migration 21.35 map04912 GnRH signaling pathway 8.99 map04310 Wnt signaling pathway 8.99 map03320 PPAR signaling pathway 3.37 map00780 Biotin metabolism 3.37 map00310 Lysine degradation This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with ZnMc domain which could be assigned to a KEGG orthologous group, and not all proteins containing ZnMc domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.
- Structure (3D structures containing this domain)
3D Structures of ZnMc domains in PDB
PDB code Main view Title 1a85 MMP8 WITH MALONIC AND ASPARAGINE BASED INHIBITOR 1a86 MMP8 WITH MALONIC AND ASPARTIC ACID BASED INHIBITOR 1af0 SERRATIA PROTEASE IN COMPLEX WITH INHIBITOR 1akl ALKALINE PROTEASE FROM PSEUDOMONAS AERUGINOSA IFO3080 1ast STRUCTURE OF ASTACIN AND IMPLICATIONS FOR ACTIVATION OF ASTACINS AND ZINC-LIGATION OF COLLAGENASES 1ayk INHIBITOR-FREE CATALYTIC FRAGMENT OF HUMAN FIBROBLAST COLLAGENASE, NMR, 30 STRUCTURES 1b3d STROMELYSIN-1 1b8y X-RAY STRUCTURE OF HUMAN STROMELYSIN CATALYTIC DOMAIN COMPLEXED WITH NON-PEPTIDE INHIBITORS: IMPLICATIONS FOR INHIBITOR SELECTIVITY 1biw DESIGN AND SYNTHESIS OF CONFORMATIONALLY-CONSTRAINED MMP INHIBITORS 1bm6 SOLUTION STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN STROMELYSIN-1 COMPLEXED TO A POTENT NON-PEPTIDIC INHIBITOR, NMR, 20 STRUCTURES 1bqo DISCOVERY OF POTENT, ACHIRAL MATRIX METALLOPROTEINASE INHIBITORS 1bqq CRYSTAL STRUCTURE OF THE MT1-MMP--TIMP-2 COMPLEX 1buv CRYSTAL STRUCTURE OF THE MT1-MMP-TIMP-2 COMPLEX 1bzs CRYSTAL STRUCTURE OF MMP8 COMPLEXED WITH HMR2909 1c3i HUMAN STROMELYSIN-1 CATALYTIC DOMAIN COMPLEXED WITH RO-26-2812 1c8t HUMAN STROMELYSIN-1 (E202Q) CATALYTIC DOMAIN COMPLEXED WITH RO-26-2812 1caq X-RAY STRUCTURE OF HUMAN STROMELYSIN CATALYTIC DOMAIN COMPLEXES WITH NON-PEPTIDE INHIBITORS: IMPLICATION FOR INHIBITOR SELECTIVITY 1cge CRYSTAL STRUCTURES OF RECOMBINANT 19-KDA HUMAN FIBROBLAST COLLAGENASE COMPLEXED TO ITSELF 1cgf CRYSTAL STRUCTURES OF RECOMBINANT 19-KDA HUMAN FIBROBLAST COLLAGENASE COMPLEXED TO ITSELF 1cgl STRUCTURE OF THE CATALYTIC DOMAIN OF FIBROBLAST COLLAGENASE COMPLEXED WITH AN INHIBITOR 1ciz X-RAY STRUCTURE OF HUMAN STROMELYSIN CATALYTIC DOMAIN COMPLEXES WITH NON-PEPTIDE INHIBITORS: IMPLICATION FOR INHIBITOR SELECTIVITY 1ck7 GELATINASE A (FULL-LENGTH) 1cqr CRYSTAL STRUCTURE OF THE STROMELYSIN CATALYTIC DOMAIN AT 2.0 A RESOLUTION 1cxv STRUCTURE OF RECOMBINANT MOUSE COLLAGENASE-3 (MMP-13) 1d5j CRYSTAL STRUCTURE OF MMP3 COMPLEXED WITH A THIAZEPINE BASED INHIBITOR. 1d7x CRYSTAL STRUCTURE OF MMP3 COMPLEXED WITH A MODIFIED PROLINE SCAFFOLD BASED INHIBITOR. 1d8f CRYSTAL STRUCTURE OF MMP3 COMPLEXED WITH A PIPERAZINE BASED INHIBITOR. 1d8m CRYSTAL STRUCTURE OF MMP3 COMPLEXED WITH A HETEROCYCLE-BASED INHIBITOR 1eak Catalytic domain of proMMP-2 E404Q mutant 1eub SOLUTION STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN COLLAGENASE-3 (MMP-13) COMPLEXED TO A POTENT NON-PEPTIDIC SULFONAMIDE INHIBITOR 1fbl STRUCTURE OF FULL-LENGTH PORCINE SYNOVIAL COLLAGENASE (MMP1) REVEALS A C-TERMINAL DOMAIN CONTAINING A CALCIUM-LINKED, FOUR-BLADED BETA-PROPELLER 1fls SOLUTION STRUCTURE OF THE CATALYTIC FRAGMENT OF HUMAN COLLAGENASE-3 (MMP-13) COMPLEXED WITH A HYDROXAMIC ACID INHIBITOR 1fm1 SOLUTION STRUCTURE OF THE CATALYTIC FRAGMENT OF HUMAN COLLAGENASE-3 (MMP-13) COMPLEXED WITH A HYDROXAMIC ACID INHIBITOR 1g05 HETEROCYCLE-BASED MMP INHIBITOR WITH P2'SUBSTITUENTS 1g49 A CARBOXYLIC ACID BASED INHIBITOR IN COMPLEX WITH MMP3 1g4k X-ray Structure of a Novel Matrix Metalloproteinase Inhibitor Complexed to Stromelysin 1g9k CRYSTAL STRUCTURE OF A PSYCHROPHILIC ALKALINE PROTEASE FROM PSEUDOMONAS TAC II 18 1gkc MMP9-inhibitor complex 1gkd MMP9 active site mutant-inhibitor complex 1go7 The metzincin's methionine: PrtC M226C-E189K double mutant 1go8 The metzincin's methionine: PrtC M226L mutant 1gxd proMMP-2/TIMP-2 complex 1h71 Psychrophilic Protease from Pseudoalteromonas haloplanctis 1hfc 1.56 ANGSTROM STRUCTURE OF MATURE TRUNCATED HUMAN FIBROBLAST COLLAGENASE 1hfs CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN FIBROBLAST STROMELYSIN-1 INHIBITED WITH THE N-CARBOXY-ALKYL INHIBITOR L-764,004 1hov SOLUTION STRUCTURE OF A CATALYTIC DOMAIN OF MMP-2 COMPLEXED WITH SC-74020 1hv5 CRYSTAL STRUCTURE OF THE STROMELYSIN-3 (MMP-11) CATALYTIC DOMAIN COMPLEXED WITH A PHOSPHINIC INHIBITOR 1hy7 A CARBOXYLIC ACID BASED INHIBITOR IN COMPLEX WITH MMP3 1i73 COMPLEX OF PRO-LEU-L-TRP PHOSPHONATE WITH THE CATALITIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM) 1i76 COMPLEX OF 2-(BIPHENYL-4-SULFONYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID (D-TIC DERIVATIVE) WITH T CATALITIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM) 1iaa CRYSTAL STRUCTURES, SPECTROSCOPIC FEATURES, AND CATALYTIC PROPERTIES OF COBALT(II), COPPER(II), NICKEL(II), AND MERCURY(II) DERIVATIVES OF THE ZINC ENDOPEPTIDASE ASTACIN. A CORRELATION OF STRUCTURE AND PROTEOLYTIC ACTIVITY 1iab CRYSTAL STRUCTURES, SPECTROSCOPIC FEATURES, AND CATALYTIC PROPERTIES OF COBALT(II), COPPER(II), NICKEL(II), AND MERCURY(II) DERIVATIVES OF THE ZINC ENDOPEPTIDASE ASTACIN. A CORRELATION OF STRUCTURE AND PROTEOLYTIC ACTIVITY 1iac REFINED 1.8 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF ASTACIN, A ZINC-ENDOPEPTIDASE FROM THE CRAYFISH ASTACUS ASTACUS L. STRUCTURE DETERMINATION, REFINEMENT, MOLECULAR STRUCTURE AND COMPARISON WITH THERMOLYSIN 1iad REFINED 1.8 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF ASTACIN, A ZINC-ENDOPEPTIDASE FROM THE CRAYFISH ASTACUS ASTACUS L. STRUCTURE DETERMINATION, REFINEMENT, MOLECULAR STRUCTURE AND COMPARISON TO THERMOLYSIN 1iae CRYSTAL STRUCTURES, SPECTROSCOPIC FEATURES, AND CATALYTIC PROPERTIES OF COBALT(II), COPPER(II), NICKEL(II), AND MERCURY(II) DERIVATIVES OF THE ZINC ENDOPEPTIDASE ASTACIN. A CORRELATION OF STRUCTURE AND PROTEOLYTIC ACTIVITY 1jan COMPLEX OF PRO-LEU-GLY-HYDROXYLAMINE WITH THE CATALYTIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (PHE79 FORM) 1jao COMPLEX OF 3-MERCAPTO-2-BENZYLPROPANOYL-ALA-GLY-NH2 WITH THE CATALYTIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM) 1jap COMPLEX OF PRO-LEU-GLY-HYDROXYLAMINE WITH THE CATALYTIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM) 1jaq COMPLEX OF 1-HYDROXYLAMINE-2-ISOBUTYLMALONYL-ALA-GLY-NH2 WITH THE CATALYTIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM) 1jh1 Crystal Structure of MMP-8 complexed with a 6H-1,3,4-thiadiazine derived inhibitor 1jiw Crystal structure of the APR-APRin complex 1jiz Crystal Structure Analysis of human Macrophage Elastase MMP-12 1jj9 Crystal Structure of MMP8-Barbiturate Complex Reveals Mechanism for Collagen Substrate Recognition 1jk3 Crystal structure of human MMP-12 (Macrophage Elastase) at true atomic resolution 1k7g PrtC from Erwinia chrysanthemi 1k7i PrtC from Erwinia chrysanthemi: Y228F mutant 1k7q PrtC from Erwinia chrysanthemi: E189A mutant 1kap THREE-DIMENSIONAL STRUCTURE OF THE ALKALINE PROTEASE OF PSEUDOMONAS AERUGINOSA: A TWO-DOMAIN PROTEIN WITH A CALCIUM BINDING PARALLEL BETA ROLL MOTIF 1kbc PROCARBOXYPEPTIDASE TERNARY COMPLEX 1l6j Crystal structure of human matrix metalloproteinase MMP9 (gelatinase B). 1mmb COMPLEX OF BB94 WITH THE CATALYTIC DOMAIN OF MATRIX METALLOPROTEINASE-8 1mmp MATRILYSIN COMPLEXED WITH CARBOXYLATE INHIBITOR 1mmq MATRILYSIN COMPLEXED WITH HYDROXAMATE INHIBITOR 1mmr MATRILYSIN COMPLEXED WITH SULFODIIMINE INHIBITOR 1mnc STRUCTURE OF HUMAN NEUTROPHIL COLLAGENASE REVEALS LARGE S1' SPECIFICITY POCKET 1o0q Crystal structure of a cold adapted alkaline protease from Pseudomonas TAC II 18, co-crystallized with 1 mM EDTA 1o0t CRYSTAL STRUCTURE OF A COLD ADAPTED ALKALINE PROTEASE FROM PSEUDOMONAS TAC II 18, CO-CRYSTALLIZED WITH 5 mM EDTA (5 DAYS) 1om6 CRYSTAL STRUCTURE OF A COLD ADAPTED ALKALINE PROTEASE FROM PSEUDOMONAS TAC II 18, CO-CRYSTALLIZED WITH 5mM EDTA (2 MONTHS) 1om7 CRYSTAL STRUCTURE OF A COLD ADAPTED ALKALINE PROTEASE FROM PSEUDOMONAS TAC II 18, SOAKED IN 85 mM EDTA 1om8 CRYSTAL STRUCTURE OF A COLD ADAPTED ALKALINE PROTEASE FROM PSEUDOMONAS TAC II 18, CO-CRYSTALLYZED WITH 10 mM EDTA 1omj CRYSTAL STRUCTURE OF A PSYCHROPHILIC ALKALINE PROTEASE FROM PSEUDOMONAS TAC II 18 1oo9 Orientation in Solution of MMP-3 Catalytic Domain and N-TIMP-1 from Residual Dipolar Couplings 1os2 Ternary enzyme-product-inhibitor complexes of human MMP12 1os9 Binary enzyme-product complexes of human MMP12 1q3a Crystal structure of the catalytic domain of human matrix metalloproteinase 10 1qia CRYSTAL STRUCTURE OF STROMELYSIN CATALYTIC DOMAIN 1qib CRYSTAL STRUCTURE OF GELATINASE A CATALYTIC DOMAIN 1qic CRYSTAL STRUCTURE OF STROMELYSIN CATALYTIC DOMAIN 1qji Structure of astacin with a transition-state analogue inhibitor 1qjj Structure of astacin with a hydroxamic acid inhibitor 1rm8 Crystal structure of the catalytic domain of MMP-16/MT3-MMP: Characterization of MT-MMP specific features 1rmz Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor NNGH at 1.3 A resolution 1ros Crystal structure of MMP-12 complexed to 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl-4-(4-ethoxy[1,1-biphenyl]-4-yl)-4-oxobutanoic acid 1sat CRYSTAL STRUCTURE OF THE 50 KDA METALLO PROTEASE FROM S. MARCESCENS 1slm CRYSTAL STRUCTURE OF FIBROBLAST STROMELYSIN-1: THE C-TRUNCATED HUMAN PROENZYME 1sln CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN FIBROBLAST STROMELYSIN-1 INHIBITED WITH THE N-CARBOXY-ALKYL INHIBITOR L-702,842 1smp CRYSTAL STRUCTURE OF A COMPLEX BETWEEN SERRATIA MARCESCENS METALLO-PROTEASE AND AN INHIBITOR FROM ERWINIA CHRYSANTHEMI 1srp STRUCTURAL ANALYSIS OF SERRATIA PROTEASE 1su3 X-ray structure of human proMMP-1: New insights into collagenase action 1uea MMP-3/TIMP-1 COMPLEX 1ums STROMELYSIN-1 CATALYTIC DOMAIN WITH HYDROPHOBIC INHIBITOR BOUND, PH 7.0, 32OC, 20 MM CACL2, 15% ACETONITRILE; NMR ENSEMBLE OF 20 STRUCTURES 1umt STROMELYSIN-1 CATALYTIC DOMAIN WITH HYDROPHOBIC INHIBITOR BOUND, PH 7.0, 32OC, 20 MM CACL2, 15% ACETONITRILE; NMR AVERAGE OF 20 STRUCTURES MINIMIZED WITH RESTRAINTS 1usn CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN FIBROBLAST STROMELYSIN-1 INHIBITED WITH THIADIAZOLE INHIBITOR PNU-142372 1utt Crystal Structure of MMP-12 complexed to 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl-4-(4-ethoxy[1,1-biphenyl]-4-yl)-4-oxobutanoic acid 1utz Crystal Structure of MMP-12 complexed to (2R)-3-({[4-[(pyridin-4-yl)phenyl]-thien-2-yl}carboxamido)(phenyl)propanoic acid 1xuc Matrix metalloproteinase-13 complexed with non-zinc binding inhibitor 1xud Matrix metalloproteinase-13 complexed with non-zinc binding inhibitor 1xur Matrix metalloproteinase-13 complexed with non-zinc binding inhibitor 1y93 Crystal structure of the catalytic domain of human MMP12 complexed with acetohydroxamic acid at atomic resolution 1ycm Solution Structure of matrix metalloproteinase 12 (MMP12) in the presence of N-Isobutyl-N-[4-methoxyphenylsulfonyl]glycyl hydroxamic acid (NNGH) 1you Crystal structure of the catalytic domain of MMP-13 complexed with a potent pyrimidinetrione inhibitor 1z3j Solution Structure of MMP12 in the presence of N-isobutyl-N-4-methoxyphenylsulfonyl]glycyl hydroxamic acid (NNGH) 1zp5 Crystal structure of the complex between MMP-8 and a N-hydroxyurea inhibitor 1zs0 Crystal structure of the complex between MMP-8 and a phosphonate inhibitor (S-enantiomer) 1ztq Crystal structure of the catalytic domain of MMP-13 complexed with WAY-033 1zvx Crystal structure of the complex between MMP-8 and a phosphonate inhibitor (R-enantiomer) 2ayk INHIBITOR-FREE CATALYTIC FRAGMENT OF HUMAN FIBROBLAST COLLAGENASE, NMR, MINIMIZED AVERAGE STRUCTURE 2clt Crystal structure of the active form (full-length) of human fibroblast collagenase. 2d1n Collagenase-3 (MMP-13) complexed to a hydroxamic acid inhibitor 2d1o Stromelysin-1 (MMP-3) complexed to a hydroxamic acid inhibitor 2ddy Solution Structure of Matrilysin (MMP-7) Complexed to Constraint Conformational Sulfonamide Inhibitor 2e2d Flexibility and variability of TIMP binding: X-ray structure of the complex between collagenase-3/MMP-13 and TIMP-2 2hu6 Crystal structure of human MMP-12 in complex with acetohydroxamic acid and a bicyclic inhibitor 2j0t Crystal Structure of the Catalytic Domain of MMP-1 in Complex with the Inhibitory Domain of TIMP-1 2jnp Solution structure of matrix metalloproteinase 3 (MMP-3) in the presence of N-isobutyl-N-[4-methoxyphenylsulfonyl]glycyl hydroxamic acid (NNGH) 2jsd Solution structure of MMP20 complexed with NNGH 2jt5 solution structure of matrix metalloproteinase 3 (MMP-3) in the presence of n-hydroxy-2-[n-(2-hydroxyethyl)biphenyl-4-sulfonamide] hydroxamic acid (MLC88) 2jt6 Solution structure of matrix metalloproteinase 3 (MMP-3) in the presence of 3-4'-cyanobyphenyl-4-yloxy)-n-hdydroxypropionamide (MMP-3 inhibitor VII) 2k2g Solution structure of the wild-type catalytic domain of human matrix metalloproteinase 12 (MMP-12) in complex with a tight-binding inhibitor 2k9c Paramagnetic shifts in solid-state NMR of Proteins to elicit structural information 2krj High-Resolution Solid-State NMR Structure of a 17.6 kDa Protein 2mlr 2MLR 2mls 2MLS 2mze 2MZE 2mzh 2MZH 2mzi 2MZI 2n8r 2N8R 2ovx MMP-9 active site mutant with barbiturate inhibitor 2ovz MMP-9 active site mutant with phosphinate inhibitor 2ow0 MMP-9 active site mutant with iodine-labeled carboxylate inhibitor 2ow1 MMP-9 active site mutant with trifluoromethyl hydroxamate inhibitor 2ow2 MMP-9 active site mutant with difluoro butanoic acid inhibitor 2ow9 Crystal structure analysis of the MMP13 catalytic domain in complex with specific inhibitor 2oxu Uninhibited form of human MMP-12 2oxw Human MMP-12 complexed with the peptide IAG 2oxz Human MMP-12 in complex with two peptides PQG and IAG 2oy2 Human MMP-8 in complex with peptide IAG 2oy4 Uninhibited human MMP-8 2ozr MMP13 Catalytic Domain Complexed with 4-{[1-methyl-2,4-dioxo-6-(3-phenylprop-1-yn-1-yl)-1,4-dihydroquinazolin-3(2H)-yl]methyl}benzoic acid 2pjt Crystal structure of the catalytic domain of MMP-13 complexed with WAY-344 2poj NMR Solution Structure of the Inhibitor-Free State of Macrophage Metalloelastase (MMP-12) 2srt CATALYTIC DOMAIN OF HUMAN STROMELYSIN-1 AT PH 5.5 AND 40OC COMPLEXED WITH INHIBITOR 2tcl STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN FIBROBLAST COLLAGENASE COMPLEXED WITH AN INHIBITOR 2usn CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN FIBROBLAST STROMELYSIN-1 INHIBITED WITH THIADIAZOLE INHIBITOR PNU-141803 2w0d Does a Fast Nuclear Magnetic Resonance Spectroscopy- and X-Ray Crystallography Hybrid Approach Provide Reliable Structural Information of Ligand-Protein Complexes? A Case Study of Metalloproteinases. 2wo8 MMP12 complex with a beta hydroxy carboxylic acid 2wo9 MMP12 complex with a beta hydroxy carboxylic acid 2woa MMP12 complex with a beta hydroxy carboxylic acid 2xs3 Structure of karilysin catalytic MMP domain 2xs4 Structure of karilysin catalytic MMP domain in complex with magnesium 2y6c The Discovery of MMP7 inhibitors Exploiting a Novel Selectivity Trigger 2y6d The Discovery of MMP7 Inhibitors Exploiting a Novel Selectivity Trigger 2yig MMP13 in complex with a novel selective non zinc binding inhibitor 2z2d Solution structure of human macrophage elastase (MMP-12) catalytic domain complexed with a gamma-keto butanoic acid inhibitor 3ayk CATALYTIC FRAGMENT OF HUMAN FIBROBLAST COLLAGENASE COMPLEXED WITH CGS-27023A, NMR, MINIMIZED AVERAGE STRUCTURE 3ayu Crystal structure of MMP-2 active site mutant in complex with APP-drived decapeptide inhibitor 3ba0 Crystal structure of full-length human MMP-12 3dng Crystal structure of the complex between MMP-8 and a non-zinc chelating inhibitor 3dpe Crystal structure of the complex between MMP-8 and a non-zinc chelating inhibitor 3dpf Crystal structure of the complex between MMP-8 and a non-zinc chelating inhibitor 3edg Crystal structure of bone morphogenetic protein 1 protease domain 3edh Crystal structure of bone morphogenetic protein 1 protease domain in complex with partially bound DMSO 3edi Crystal structure of tolloid-like protease 1 (TLL-1) protease domain 3ehx Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor (R)-2-(biphenyl-4-ylsulfonamido)-4-methylpentanoic acid 3ehy Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor (R)-2-(4-methoxyphenylsulfonamido)propanoic acid 3elm Crystal Structure of MMP-13 Complexed with Inhibitor 24f 3f15 Crystal structure of the catalytic domain of human mmp12 complexed with the inhibitor (S)-N-(2,3-dihydroxypropyl)-4-methoxy-N-(2-nitroso-2-oxoethyl)benzenesulfonamide 3f16 Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor (R)-N-(3-hydroxy-1-nitroso-1-oxopropan-2-yl)-4-methoxybenzenesulfonamide 3f17 Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor N-(2-nitroso-2-oxoethyl)biphenyl-4-sulfonamide 3f18 Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor 4-fluoro-N-(2-hydroxyethyl)-N-(2-nitroso-2-oxoethyl)benzenesulfonamide 3f19 Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor 4-fluoro-N-(2-nitroso-2-oxoethyl)benzenesulfonamide 3f1a Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor N-(2-nitroso-2-oxoethyl)benzenesulfonamide 3hb2 PrtC methionine mutants: M226I 3hbu PrtC methionine mutants: M226H DESY 3hbv PrtC methionine mutants: M226A in-house 3hda PrtC methionine mutants: M226A_DESY 3i7g MMP-13 in complex with a non zinc-chelating inhibitor 3i7i MMP-13 in complex with a non zinc-chelating inhibitor 3kec Crystal Structure of Human MMP-13 complexed with a phenyl-2H-tetrazole compound 3kej Crystal Structure of Human MMP-13 complexed with a (pyridin-4-yl)-2H-tetrazole compound 3kek Crystal Structure of Human MMP-13 complexed with a (pyridin-4-yl)-2H-tetrazole compound 3kry Crystal structure of MMP-13 in complex with SC-78080 3lik Human MMP12 in complex with non-zinc chelating inhibitor 3lil Human MMP12 in complex with non-zinc chelating inhibitor 3lir Human MMP12 in complex with non-zinc chelating inhibitor 3ljg Human MMP12 in complex with non-zinc chelating inhibitor 3ljz Crystal Structure of Human MMP-13 complexed with an Amino-2-indanol compound 3lk8 Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor paramethoxy-sulfonyl-glycine hydroxamate 3lka Catalytic domain of human MMP-12 complexed with hydroxamic acid and paramethoxy-sulfonyl amide 3lq0 Zymogen structure of crayfish astacin metallopeptidase 3lqb Crystal structure of the hatching enzyme ZHE1 from the zebrafish Danio rerio 3ma2 Complex membrane type-1 matrix metalloproteinase (MT1-MMP) with tissue inhibitor of metalloproteinase-1 (TIMP-1) 3n2u Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor N-hydroxy-2-(4-methoxy-N(2-(3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)ethyl)phenylsulfonamido)acetamide 3n2v Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor N-hydroxy-2-(N-hydroxyethyl)biphenyl-4-ylsulfonamido)acetamide 3nx7 Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor N-Hydroxy-2-(N-(2-hydroxyethyl)4-methoxyphenylsulfonamido)acetamide 3o2x MMP-13 in complex with selective tetrazole core inhibitor 3ohl catalytic domain of stromelysin-1 in complex with N-Hydroxy-2-(4-methoxy-N-(pyridine-3-ylmethyl)phenylsulfonamido)acetamide 3oho catalytic domain of stromelysin-1 in complex with N-Hydroxy-2-(4-methylphenylsulfonamido)acetamide 3p24 Structure of profragilysin-3 from Bacteroides fragilis 3rts Human MMP-12 catalytic domain in complex with*N*-Hydroxy-2-(2-phenylethylsulfonamido)acetamide 3rtt Human MMP-12 catalytic domain in complex with*(R)-N*-Hydroxy-1-(phenethylsulfonyl)pyrrolidine-2-carboxamide 3shi Crystal structure of human MMP1 catalytic domain at 2.2 A resolution 3ts4 Human MMP12 in complex with L-glutamate motif inhibitor 3tsk Human MMP12 in complex with L-glutamate motif inhibitor 3tt4 Human MMP8 in complex with L-glutamate motif inhibitor 3tvc Human MMP13 in complex with L-glutamate motif inhibitor 3u1r Structure Analysis of A New Psychrophilic Marine Protease 3usn STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN FIBROBLAST STROMELYSIN-1 INHIBITED WITH THE THIADIAZOLE INHIBITOR IPNU-107859, NMR, 1 STRUCTURE 3uvc MMP12 in a complex with the dimeric adduct: 5-(5-phenylhydantoin)-5-phenylhydantoin 3v96 Complex of matrix metalloproteinase-10 catalytic domain (MMP-10cd) with tissue inhibitor of metalloproteinases-1 (TIMP-1) 3vi1 Crystal structure of Pseudomonas aerginosa alkaline protease complexed with Substance P(1-6) 3vtg High choriolytic enzyme 1 (HCE-1), a hatching enzyme zinc-protease from Oryzias latipes (Medaka fish) 3wv1 3WV1 3wv2 3WV2 3wv3 3WV3 3zxh MMP-13 complexed with 2-Napthylsulfonamide hydroxamic acid inhibitor 456c CRYSTAL STRUCTURE OF COLLAGENASE-3 (MMP-13) COMPLEXED TO A DIPHENYL-ETHER SULPHONE BASED HYDROXAMIC ACID 4a7b MMP13 IN COMPLEX WITH A NOVEL SELECTIVE NON ZINC BINDING INHIBITOR CMPD22 4auo Crystal structure of MMP-1(E200A) in complex with a triple-helical collagen peptide 4ayk CATALYTIC FRAGMENT OF HUMAN FIBROBLAST COLLAGENASE COMPLEXED WITH CGS-27023A, NMR, 30 STRUCTURES 4dpe Structure of MMP3 complexed with a platinum-based inhibitor. 4efs Human MMP12 in complex with L-glutamate motif inhibitor 4fu4 Human collagenase 3 (MMP-13) with peptide from pro-domain 4fvl Human collagenase 3 (MMP-13) full form with peptides from pro-domain 4g0d Human collagenase 3 (MMP-13) full form with peptides from pro-domain 4g9l Structure of MMP3 complexed with NNGH inhibitor. 4gql Crystal structure of the catalytic domain of Human MMP12 in complex with selective phosphinic inhibitor RXP470.1 4gr0 Crystal structure of the catalytic domain of Human MMP12 in complex with selective phosphinic inhibitor RXP470B 4gr3 Crystal structure of the catalytic domain of Human MMP12 in complex with selective phosphinic inhibitor RXP470A 4gr8 Crystal structure of the catalytic domain of Human MMP12 in complex with selective phosphinic inhibitor RXP470C 4guy Human MMP12 catalytic domain in complex with*N*-Hydroxy-2-(2-(4-methoxyphenyl)ethylsulfonamido)acetamide 4gwm Crystal structure of human promeprin beta 4gwn Crystal structure of human mature meprin beta 4h1q Crystal structure of mutant MMP-9 catalytic domain in complex with a twin inhibitor. 4h2e Crystal structure of an MMP twin inhibitor complexing two MMP-9 catalytic domains 4h30 Crystal structure of the catalytic domain of MMP-12 in complex with a twin inhibitor. 4h3x Crystal structure of an MMP broad spectrum hydroxamate based inhibitor CC27 in complex with the MMP-9 catalytic domain 4h49 Crystal structure of the catalytic domain of MMP-12 in complex with a twin inhibitor. 4h76 Crystal structure of the catalytic domain of Human MMP12 in complex with a broad spectrum hydroxamate inhibitor 4h82 Crystal structure of mutant MMP-9 catalytic domain in complex with a twin inhibitor. 4h84 Crystal structure of the catalytic domain of Human MMP12 in complex with a selective carboxylate based inhibitor. 4hma Crystal structure of an MMP twin carboxylate based inhibitor LC20 in complex with the MMP-9 catalytic domain 4i03 Human MMP12 in complex with a PEG-linked bifunctional L-glutamate motif inhibitor 4i35 The crystal structure of serralysin 4ijo Unraveling hidden allosteric regulatory sites in structurally homologues metalloproteases 4ilw Complex of matrix metalloproteinase-10 catalytic domain (MMP-10cd) with tissue inhibitor of metalloproteinases-2 (TIMP-2) 4in9 Structure of karilysin MMP-like catalytic domain in complex with inhibitory tetrapeptide SWFP 4ja1 Structure of MMP3 complexed with a platinum-based inhibitor 4jij Crystal structure of an inactive mutant of MMP-9 catalytic domain in complex with a fluorogenic synthetic peptidic substrate 4jp4 Mmp13 in complex with a reverse hydroxamate Zn-binder 4jpa Mmp13 in complex with a piperazine hydantoin ligand 4jqg Crystal structure of an inactive mutant of MMP-9 catalytic domain in complex with a fluorogenic synthetic peptidic substrate with a fluorine atom. 4l19 4L19 4on1 Crystal Structure of metalloproteinase-II from Bacteroides fragilis 4qkz 4QKZ 4r3v 4R3V 4wzv 4WZV 4xct 4XCT 5bot 5BOT 5boy 5BOY 5bpa 5BPA 5cuh 5CUH 5cxa 5CXA 5czm 5CZM 5czw 5CZW 5d2b 5D2B 5d3c 5D3C 5d7w 5D7W 5h8x 5H8X 5i0l 5I0L 5i12 5I12 5i2z 5I2Z 5i3m 5I3M 5i43 5I43 5i4o 5I4O 5l79 5L79 5l7f 5L7F 5lab 5LAB 830c COLLAGENASE-3 (MMP-13) COMPLEXED TO A SULPHONE-BASED HYDROXAMIC ACID 966c CRYSTAL STRUCTURE OF FIBROBLAST COLLAGENASE-1 COMPLEXED TO A DIPHENYL-ETHER SULPHONE BASED HYDROXAMIC ACID - Links (links to other resources describing this domain)
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INTERPRO IPR006026