The domain within your query sequence starts at position 822 and ends at position 888; the E-value for the efhand_Ca_insen domain shown below is 5.22e-38.
EF hands are helix-loop-helix binding motifs involved in the regulation of many cellular processes. EF hands usually bind to Ca2+ ions which causes a major conformational change that allows the protein to interact with its designated targets. This domain corresponds to an EF hand which has partially or entirely lost its calcium-binding properties. The calcium insensitive EF hand is still able to mediate protein-protein recognition (PUBMED:11573089).
Family alignment:
There are 3751 efhand_Ca_insen domains in 3743 proteins in SMART's nrdb database.
Click on the following links for more information.
Evolution (species in which this domain is found)
Taxonomic distribution of proteins containing efhand_Ca_insen domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with efhand_Ca_insen domain is also avaliable.
Click on the protein counts, or double click on taxonomic names to display all proteins containing efhand_Ca_insen domain in the selected taxonomic class.
Ca2+-independent binding of an EF-hand domain to a novel motif in thealpha-actinin-titin complex.
Nat Struct Biol. 2001; 8: 853-7
Display abstract
The interaction between alpha-actinin and titin, two modular muscle proteins, is essential for sarcomere assembly. We have solved the solution structure of acomplex between the calcium-insensitive C-terminal EF-hand domain ofalpha-actinin-2 and the seventh Z-repeat of titin. The structure of the complexis in a semi-open conformation and closely resembles that of myosin light chains in their complexes with heavy chain IQ motifs. However, no IQ motif is present inthe Z-repeat, suggesting that the semi-open conformation is a general structural solution for calcium-independent recognition of EF-hand domains.
