| Domain | Description |
|---|---|
| 14_3_3 | 14-3-3 homologues |
| 35EXOc | 3'-5' exonuclease |
| 4.1m | putative band 4.1 homologues' binding motif |
| 53EXOc | 5'-3' exonuclease |
| 6PGD | 6-phosphogluconate dehydrogenase, C-terminal domain |
| 7TM_GPCR_Srsx | Serpentine type 7TM GPCR chemoreceptor Srsx |
| A1pp | Appr-1"-p processing enzyme |
| A2M | Alpha-2-macroglobulin family |
| A2M_N_2 | Alpha-2-Macroglobulin |
| A2M_recep | A-macroglobulin receptor |
| A4_EXTRA | amyloid A4 |
| A_amylase_inhib | Alpha amylase inhibitor |
| AAA | ATPases associated with a variety of cellular activities |
| AAA_PrkA | PrkA AAA domain |
| AAI | Plant lipid transfer protein / seed storage protein / trypsin-alpha amylase inhibitor domain family |
| Aamy | Alpha-amylase domain |
| Aamy_C | |
| AARP2CN | AARP2CN (NUC121) domain |
| acidPPc | Acid phosphatase homologues |
| ACR | ADAM Cysteine-Rich Domain |
| ACTH_domain | Corticotropin ACTH domain |
| ACTIN | Actin |
| AD | Anticodon-binding domain |
| Ad_cyc_g-alpha | Adenylate cyclase G-alpha binding domain |
| ADEAMc | tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase) |
| Adenylsucc_synt | Adenylosuccinate synthetase |
| ADF | Actin depolymerisation factor/cofilin -like domains |
| AdoHcyase | S-adenosyl-L-homocysteine hydrolase |
| AdoHcyase_NAD | S-adenosyl-L-homocysteine hydrolase, NAD binding domain |
| ADSL_C | Adenylosuccinate lyase C-terminus |
| Aerolysin | Aerolysin toxin |
| AFOR_N | Aldehyde ferredoxin oxidoreductase, N-terminal domain |
| Agenet | Tudor-like domain present in plant sequences. |
| Agglutinin | |
| Agouti | Agouti protein |
| AgrB | Accessory gene regulator B |
| AgrD | Staphylococcal AgrD protein |
| Agro_virD5 | Agrobacterium VirD5 protein |
| AGTRAP | Angiotensin II, type I receptor-associated protein |
| Aha1_N | Activator of Hsp90 ATPase, N-terminal |
| AHS1 | Allophanate hydrolase subunit 1 |
| AHS2 | Allophanate hydrolase subunit 2 |
| AICARFT_IMPCHas | AICARFT/IMPCHase bienzyme |
| AIF_C | Apoptosis-inducing factor, mitochondrion-associated, C-term |
| AIP3 | Actin interacting protein 3 |
| AIRC | AIR carboxylase |
| AKAP_110 | A-kinase anchor protein 110 kDa |
| Ala_racemase_C | Alanine racemase, C-terminal domain |
| ALAD | Delta-aminolevulinic acid dehydratase |
| AlaDh_PNT_C | Alanine dehydrogenase/PNT, C-terminal domain |
| AlaDh_PNT_N | Alanine dehydrogenase/PNT, N-terminal domain |
| ALBUMIN | serum albumin |
| AlcB | Siderophore biosynthesis protein domain |
| Ald_Xan_dh_C | Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain |
| Aldolase_II | Class II Aldolase and Adducin N-terminal domain |
| AlkA_N | AlkA N-terminal domain |
| alkPPc | Alkaline phosphatase homologues |
| Alpha-amyl_C2 | Alpha-amylase C-terminal beta-sheet domain |
| Alpha-L-AF_C | Alpha-L-arabinofuranosidase C-terminus |
| Alpha-mann_mid | Alpha mannosidase, middle domain |
| Alpha_adaptinC2 | Adaptin C-terminal domain |
| Alpha_kinase | Alpha-kinase family |
| Alpha_L_fucos | Alpha-L-fucosidase |
| Alpha_TIF | Alpha trans-inducing protein (Alpha-TIF) |
| AMA-1 | Apical membrane antigen 1 |
| Amb_all | |
| Amb_V_allergen | Amb V Allergen |
| Amelin | Ameloblastin precursor (Amelin) |
| Amelogenin | |
| Ami_2 | |
| Ami_3 | |
| AMOP | Adhesion-associated domain present in MUC4 and other proteins |
| AMP_N | Aminopeptidase P, N-terminal domain |
| AMPKBI | 5'-AMP-activated protein kinase beta subunit, interation domain |
| ANATO | Anaphylatoxin homologous domain |
| ANK | ankyrin repeats |
| ANTAR | |
| Antimicrobial21 | Plant antimicrobial peptide |
| ANX | Annexin repeats |
| AP2 | DNA-binding domain in plant proteins such as APETALA2 and EREBPs |
| AP2Ec | AP endonuclease family 2 |
| AP3B1_C | Clathrin-adaptor complex-3 beta-1 subunit C-terminal |
| AP4E_app_platf | Adaptin AP4 complex epsilon appendage platform |
| APC10 | Anaphase-promoting complex, subunit 10 (APC10) |
| APC2 | Anaphase promoting complex (APC) subunit 2 |
| APCDDC | Adenomatosis polyposis coli down-regulated 1 |
| APPLE | APPLE domain |
| AraC_E_bind | Bacterial transcription activator, effector binding domain |
| Arch1 | sub-family of tyrosine recombinases |
| Arch2 | sub-family of tyrosine recombinases |
| ARF | ARF-like small GTPases; ARF, ADP-ribosylation factor |
| Arfaptin | Arfaptin-like domain |
| ArfGap | Putative GTP-ase activating proteins for the small GTPase, ARF |
| Arg_tRNA_synt_N | Arginyl tRNA synthetase N terminal dom |
| ARID | ARID/BRIGHT DNA binding domain |
| ARM | Armadillo/beta-catenin-like repeats |
| Arrestin_C | Arrestin (or S-antigen), C-terminal domain |
| ASCH | |
| Asparaginase | |
| Aspzincin_M35 | Lysine-specific metallo-endopeptidase |
| AT_hook | DNA binding domain with preference for A/T rich regions |
| Autotransporter | Autotransporter beta-domain |
| AWS | associated with SET domains |
| AXH | domain in Ataxins and HMG containing proteins |
| B12-binding_2 | B12 binding domain |
| B2-adapt-app_C | Beta2-adaptin appendage, C-terminal sub-domain |
| B3 | B3 DNA binding domain |
| B3_4 | B3/4 domain |
| B41 | Band 4.1 homologues |
| B5 | tRNA synthetase B5 domain |
| B561 | Cytochrome b-561 / ferric reductase transmembrane domain. |
| B_lectin | Bulb-type mannose-specific lectin |
| Bac_DnaA_C | Bacterial dnaA protein helix-turn-helix domain |
| Bac_rhodopsin | Bacteriorhodopsin-like protein |
| BACK | BTB And C-terminal Kelch |
| BAF | Barrier to autointegration factor |
| BAG | BAG domains, present in regulator of Hsp70 proteins |
| BAH | Bromo adjacent homology domain |
| BAR | |
| BASIC | Basic domain in HLH proteins of MYOD family |
| BATS | Biotin and Thiamin Synthesis associated domain |
| BBC | B-Box C-terminal domain |
| BBOX | B-Box-type zinc finger |
| BC10 | Bladder cancer-related protein BC10 |
| BCL | BCL (B-Cell lymphoma); contains BH1, BH2 regions |
| BCS1_N | |
| Beach | Beige/BEACH domain |
| BEN | |
| Bet_v_1 | Pathogenesis-related protein Bet v I family |
| Beta-Casp | Beta-Casp domain |
| Beta-TrCP_D | D domain of beta-TrCP |
| BetaGal_dom2 | Beta-galactosidase, domain 2 |
| Bgal_small_N | Beta galactosidase small chain |
| BH4 | BH4 Bcl-2 homology region 4 |
| BHD_1 | Rad4 beta-hairpin domain 1 |
| BHD_2 | Rad4 beta-hairpin domain 2 |
| BHD_3 | Rad4 beta-hairpin domain 3 |
| BHL | bacterial (prokaryotic) histone like domain |
| BID_1 | Bacterial Ig-like domain (group 1) |
| BID_2 | Bacterial Ig-like domain 2 |
| BING4CT | BING4CT (NUC141) domain |
| Biotin_carb_C | Biotin carboxylase C-terminal domain |
| BIR | Baculoviral inhibition of apoptosis protein repeat |
| BLUF | Sensors of blue-light using FAD |
| BLVR | Bovine leukaemia virus receptor (BLVR) |
| BMC | |
| BON | bacterial OsmY and nodulation domain |
| BOP1NT | BOP1NT (NUC169) domain |
| BowB | Bowman-Birk type proteinase inhibitor |
| BP28CT | BP28CT (NUC211) domain |
| BPI1 | BPI/LBP/CETP N-terminal domain |
| BPI2 | BPI/LBP/CETP C-terminal domain |
| BRCT | breast cancer carboxy-terminal domain |
| BRICHOS | |
| BRIGHT | BRIGHT, ARID (A/T-rich interaction domain) domain |
| Brix | |
| BRK | domain in transcription and CHROMO domain helicases |
| BRLZ | basic region leucin zipper |
| Bro-N | BRO family, N-terminal domain |
| BRO1 | BRO1-like domain |
| BROMO | bromo domain |
| Brr6_like_C_C | Di-sulfide bridge nucleocytoplasmic transport domain |
| BSD | domain in transcription factors and synapse-associated proteins |
| BTAD | Bacterial transcriptional activator domain |
| BTB | Broad-Complex, Tramtrack and Bric a brac |
| BTD | Beta-trefoil DNA-binding domain |
| btg1 | tob/btg1 family |
| BTK | Bruton's tyrosine kinase Cys-rich motif |
| BTP | Bromodomain transcription factors and PHD domain containing proteins |
| Btz | CASC3/Barentsz eIF4AIII binding |
| BURP | |
| c-clamp | |
| c-SKI_SMAD_bind | c-SKI Smad4 binding domain |
| C1 | Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) |
| C1_4 | TFIIH C1-like domain |
| C1Q | Complement component C1q domain. |
| C2 | Protein kinase C conserved region 2 (CalB) |
| C345C | Netrin C-terminal Domain |
| C4 | C-terminal tandem repeated domain in type 4 procollagens |
| C6 | |
| C8 | |
| CA | Cadherin repeats. |
| Ca_chan_IQ | Voltage gated calcium channel IQ domain |
| Cache_2 | |
| CactinC_cactus | Cactus-binding C-terminus of cactin protein |
| CAD | Domains present in proteins implicated in post-mortem DNA fragmentation |
| CADG | Dystroglycan-type cadherin-like domains. |
| Cadherin_pro | Cadherin prodomain like |
| CALCITONIN | calcitonin |
| calpain_III | |
| Calx_beta | Domains in Na-Ca exchangers and integrin-beta4 |
| CaM_binding | Plant calmodulin-binding domain |
| CaMBD | Calmodulin binding domain |
| CAMSAP_CKK | Microtubule-binding calmodulin-regulated spectrin-associated |
| Candida_ALS_N | Cell-wall agglutinin N-terminal ligand-sugar binding |
| Candidate | sub-family of tyrosine recombinases |
| CAP10 | Putative lipopolysaccharide-modifying enzyme. |
| CAP_GLY | |
| Carb_anhydrase | Eukaryotic-type carbonic anhydrase |
| CARD | Caspase recruitment domain |
| CarD_TRCF | CarD-like/TRCF domain |
| CARP | Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product. |
| cas1 | cas1 solo endonuclease |
| CASc | Caspase, interleukin-1 beta converting enzyme (ICE) homologues |
| CASH | Domain present in carbohydrate binding proteins and sugar hydrolses |
| CAT | Chloramphenicol acetyltransferase |
| CAT_RBD | CAT RNA binding domain |
| Catalase | |
| Cation_ATPase_N | Cation transporter/ATPase, N-terminus |
| CBD_II | |
| CBD_IV | Cellulose Binding Domain Type IV |
| CBF | CCAAT-Binding transcription Factor |
| CBM49 | Carbohydrate binding domain CBM49 |
| CBM_10 | Cellulose or protein binding domain |
| CBM_2 | Starch binding domain |
| CBM_25 | Carbohydrate binding domain |
| CBM_3 | Cellulose binding domain |
| CBM_X | Putative carbohydrate binding domain |
| CBS | Domain in cystathionine beta-synthase and other proteins. |
| CCP | Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR) |
| CDC37_C | Cdc37 C terminal domain |
| CDC37_M | Cdc37 Hsp90 binding domain |
| CDC37_N | Cdc37 N terminal kinase binding |
| CDC48_2 | Cell division protein 48 (CDC48) domain 2 |
| CDC48_N | Cell division protein 48 (CDC48) N-terminal domain |
| Cdc6_C | CDC6, C terminal |
| CDT1 | DNA replication factor CDT1 like |
| CENPB | Putative DNA-binding domain in centromere protein B, mouse jerky and transposases. |
| CFEM | |
| CG-1 | |
| Cg6151-P | Uncharacterized conserved protein CG6151-P |
| CGGC | |
| CH | Calponin homology domain |
| CHAD | |
| CHASE | |
| CHASE2 | |
| CHB_HEX | Putative carbohydrate binding domain |
| CheW | Two component signalling adaptor domain |
| CHK | ZnF_C4 abd HLH domain containing kinases domain |
| CHRD | A domain in the BMP inhibitor chordin and in microbial proteins. |
| CHROMO | Chromatin organization modifier domain |
| ChSh | Chromo Shadow Domain |
| ChtBD1 | Chitin binding domain |
| ChtBD2 | Chitin-binding domain type 2 |
| ChtBD3 | Chitin-binding domain type 3 |
| ChW | Clostridial hydrophobic, with a conserved W residue, domain. |
| CHZ | Histone chaperone domain CHZ |
| CIMR | Cation-independent mannose-6-phosphate receptor repeat |
| Cir_N | N-terminal domain of CBF1 interacting co-repressor CIR |
| Citrate_ly_lig | Citrate lyase ligase C-terminal domain |
| CK_II_beta | Casein kinase II regulatory subunit |
| CKS | Cyclin-dependent kinase regulatory subunit |
| CLa | CLUSTERIN alpha chain |
| CLb | CLUSTERIN Beta chain |
| CLECT | C-type lectin (CTL) or carbohydrate-recognition domain (CRD) |
| CLH | Clathrin heavy chain repeat homology |
| CLIP | Clip or disulphide knot domain |
| ClpB_D2-small | C-terminal, D2-small domain, of ClpB protein |
| CM_2 | Chorismate mutase type II |
| CNH | Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2 |
| cNMP | Cyclic nucleotide-monophosphate binding domain |
| CNX | Connexin homologues |
| CO_deh_flav_C | CO dehydrogenase flavoprotein C-terminal domain |
| CoA_binding | CoA binding domain |
| CoA_trans | Coenzyme A transferase |
| CobW_C | Cobalamin synthesis protein cobW C-terminal domain |
| Cog4 | COG4 transport protein |
| COG6 | Conserved oligomeric complex COG6 |
| Col_cuticle_N | Nematode cuticle collagen N-terminal domain |
| COLFI | Fibrillar collagens C-terminal domain |
| COLIPASE | Colipase |
| Connexin_CCC | Gap junction channel protein cysteine-rich domain |
| Copper-fist | |
| CorC_HlyC | Transporter associated domain |
| Cornichon | |
| Costars | |
| CP12 | |
| CpcD | CpcD/allophycocyanin linker domain |
| CPDc | catalytic domain of ctd-like phosphatases |
| Cpl-7 | Cpl-7 lysozyme C-terminal domain |
| Cpn10 | Chaperonin 10 Kd subunit |
| CPSase_L_D3 | Carbamoyl-phosphate synthetase large chain, oligomerisation domain |
| CPSase_sm_chain | Carbamoyl-phosphate synthase small chain, CPSase domain |
| CPSF73-100_C | |
| CPW_WPC | |
| CRA | CT11-RanBPM |
| CRAL_TRIO_N | CRAL/TRIO, N-terminal domain |
| CRF | corticotropin-releasing factor |
| CRISPR_assoc | |
| CRM1_C | CRM1 C terminal |
| CRS1_YhbY | |
| CSF2 | Granulocyte-macrophage colony-simulating factor (GM-CSF) |
| CSP | Cold shock protein domain |
| CT | C-terminal cystine knot-like domain (CTCK) |
| CTD | Spt5 C-terminal nonapeptide repeat binding Spt4 |
| CTLH | C-terminal to LisH motif. |
| CTNS | Repeated motif present between transmembrane helices in cystinosin, yeast ERS1p, mannose-P-dolichol utilization defect 1, and other hypothetical proteins. |
| Cu_FIST | Copper-Fist |
| CUB | Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. |
| CUE | Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs) |
| CULLIN | Cullin |
| Cullin_Nedd8 | Cullin protein neddylation domain |
| Cupin_1 | Cupin |
| CUT | |
| Cutinase | |
| CVNH | |
| CW | |
| cwf21 | |
| CXC | Tesmin/TSO1-like CXC domain |
| CxxC_CXXC_SSSS | Putative regulatory protein |
| CY | Cystatin-like domain |
| Cyan | sub-family of tyrosine recombinases |
| Cyanate_lyase | Cyanate lyase C-terminal domain, Cyanate hydratase |
| CYCc | Adenylyl- / guanylyl cyclase, catalytic domain |
| CYCLIN | domain present in cyclins, TFIIB and Retinoblastoma |
| Cyclin_C | |
| CysPc | Calpain-like thiol protease family. |
| Cyt-b5 | Cytochrome b5-like Heme/Steroid binding domain |
| CYTH | |
| D-ser_dehydrat | Putative serine dehydratase domain |
| D5_N | D5 N terminal like |
| Dabb | Stress responsive A/B Barrel Domain |
| DAGKa | Diacylglycerol kinase accessory domain (presumed) |
| DAGKc | Diacylglycerol kinase catalytic domain (presumed) |
| Dak1_2 | |
| Dak2 | |
| DALR_1 | DALR anticodon binding domain |
| DALR_2 | |
| DAX | Domain present in Dishevelled and axin |
| DBB | Dof, BCAP, and BANK (DBB) motif |
| DBC1 | |
| DBP10CT | DBP10CT (NUC160) domain |
| DBR1 | Lariat debranching enzyme, C-terminal domain |
| DCD | |
| DCP2 | Dcp2, box A domain |
| DCX | Domain in the Doublecortin (DCX) gene product |
| DDE | family of Ribonuclease H like domains involved in transposition |
| DDE_1 | DDE transposase sub-family |
| DDE_2 | DDE Mu phage transposase sub-family |
| DDE_3 | DDE transposase sub-family |
| DDE_5 | DDE transposase sub-family |
| DDE_Tnp_1 | DDE transposase sub-family |
| DDE_Tnp_1_2 | DDE transposase sub-family |
| DDE_Tnp_1_3 | DDE transposase sub-family |
| DDE_Tnp_1_4 | DDE transposase sub-family |
| DDE_Tnp_1_5 | DDE transposase sub-family |
| DDE_Tnp_1_6 | DDE transposase sub-family |
| DDE_Tnp_1_7 | DDE transposase sub-family |
| DDE_Tnp_2 | DDE transposase sub-family |
| DDE_Tnp_4 | DDE transposase sub-family |
| DDE_Tnp_IS1 | DDE transposase sub-family |
| DDE_Tnp_IS1595 | DDE transposase sub-family |
| DDE_Tnp_IS240 | DDE transposase sub-family |
| DDE_Tnp_IS66 | DDE transposase sub-family |
| DDE_Tnp_ISAZ013 | DDE transposase sub-family |
| DDE_Tnp_ISL3 | DDE transposase sub-family |
| DDE_Tnp_Tn3 | DDE transposase sub-family |
| dDENN | Domain always found downstream of DENN domain, found in a variety of signalling proteins |
| DDHD | |
| DDRGK | |
| DDT | domain in different transcription and chromosome remodeling factors |
| DEATH | DEATH domain, found in proteins involved in cell death (apoptosis). |
| DED | Death effector domain |
| DEDD | DEDD transposase |
| DEDD_Tnp_IS110 | DEDD transposase family |
| Defensin_propep | Defensin propeptide |
| DEFSN | Defensin/corticostatin family |
| DELLA | Transcriptional regulator DELLA protein N terminal |
| DENN | Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN |
| DeoC | DeoC/LacD family aldolase |
| DeoRC | DeoR C terminal sensor domain |
| DEP | Domain found in Dishevelled, Egl-10, and Pleckstrin |
| DEXDc | DEAD-like helicases superfamily |
| DEXDc2 | |
| DEXDc3 | |
| DHDPS | Dihydrodipicolinate synthetase family |
| DHHA2 | |
| DIL | |
| DIM1 | Mitosis protein DIM1 |
| DIRP | |
| DISIN | Homologues of snake disintegrins |
| DKCLD | DKCLD (NUC011) domain |
| DM | Doublesex DNA-binding motif |
| DM10 | Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases. |
| DM11 | Domains in hypothetical proteins in Drosophila including 2 in CG15241 and CG9329. |
| DM13 | Domain present in fly proteins (CG14681, CG12492, CG6217), worm H06A10.1 and Arabidopsis thaliana MBG8.9. |
| DM14 | Repeats in fly CG4713, worm Y37H9A.3 and human FLJ20241. |
| DM15 | Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function. |
| DM16 | Repeats in sea squirt COS41.4, worm R01H10.6, fly CG1126 etc. |
| DM3 | Zinc finger domain in CG10631, C. elegans LIN-15B and human P52rIPK. |
| DM4_12 | DM4/DM12 family of domains in Drosophila melanogaster proteins of unknown function. |
| DM5 | Domain of unknown function, currently peculiar to Drosophila. |
| DM6 | Cysteine-rich domain currently specific to Drosophila. |
| DM7 | Domain of unknown function in Drosophila CG15332, CG15333 and CG18293 |
| DM8 | Repeats found in several Drosophila proteins. |
| DM9 | Repeats found in Drosophila proteins. |
| DMAP_binding | DMAP1-binding Domain |
| DNA_mis_repair | DNA mismatch repair protein, C-terminal domain |
| DnaG_DnaB_bind | DNA primase DnaG DnaB-binding |
| DnaJ | DnaJ molecular chaperone homology domain |
| DNaseIc | deoxyribonuclease I |
| DoH | Possible catecholamine-binding domain present in a variety of eukaryotic proteins. |
| DP | Transcription factor DP |
| DPBB_1 | Rare lipoprotein A (RlpA)-like double-psi beta-barrel |
| Drf_FH3 | Diaphanous FH3 Domain |
| Drf_GBD | Diaphanous GTPase-binding Domain |
| DRY_EERY | Alternative splicing regulator |
| DSHCT | |
| DSL | delta serrate ligand |
| DSPc | Dual specificity phosphatase, catalytic domain |
| DSRM | Double-stranded RNA binding motif |
| DSS1_SEM1 | |
| DSX_dimer | Doublesex dimerisation domain |
| DTW | |
| DUF1041 | Domain of Unknown Function (DUF1041) |
| DUF106 | Integral membrane protein DUF106 |
| DUF1086 | Domain of Unknown Function (DUF1086) |
| DUF1087 | |
| DUF1220 | Repeat of unknown function (DUF1220) |
| DUF1237 | |
| DUF1338 | |
| DUF1518 | |
| DUF167 | |
| DUF1693 | Domain of unknown function (DUF1693) |
| DUF1704 | |
| DUF1713 | Mitochondrial domain of unknown function (DUF1713) |
| DUF1716 | Eukaryotic domain of unknown function (DUF1716) |
| DUF1719 | |
| DUF1741 | |
| DUF1744 | |
| DUF1751 | Eukaryotic integral membrane protein (DUF1751) |
| DUF1767 | |
| DUF1771 | |
| DUF1785 | |
| DUF1856 | |
| DUF1866 | |
| DUF1899 | |
| DUF1900 | |
| DUF1907 | |
| DUF1943 | |
| DUF1944 | |
| DUF3160 | |
| DUF3385 | Domain of unknown function |
| DUF3402 | Domain of unknown function (DUF3402) |
| DUF3452 | Domain of unknown function (DUF3452) |
| DUF3454 | Domain of unknown function |
| DUF3480 | Domain of unknown function (DUF3480) |
| DUF3585 | |
| DUF3635 | Domain of unknown function |
| DUF3700 | |
| DUF4187 | |
| DUF4205 | |
| DUF4206 | |
| DUF4208 | |
| DUF4210 | |
| DUF4217 | |
| DUF663 | Protein of unknown function (DUF663) |
| DUF862 | PPPDE putative peptidase domain |
| DUSP | Domain in ubiquitin-specific proteases. |
| DWA | Domain A in dwarfin family proteins |
| DWB | Domain B in dwarfin family proteins |
| DWNN | |
| DYNc | Dynamin, GTPase |
| Dynein_light | Dynein light chain type 1 |
| DysFC | Dysferlin domain, C-terminal region. |
| DysFN | Dysferlin domain, N-terminal region. |
| DZF | domain in DSRM or ZnF_C2H2 domain containing proteins |
| E2_bind | |
| E2F_TDP | E2F/DP family winged-helix DNA-binding domain |
| EAL | Putative diguanylate phosphodiesterase |
| EB_dh | Ethylbenzene dehydrogenase |
| ECSIT_Cterm | C-terminal domain of the ECSIT protein |
| EF-1_beta_acid | Eukaryotic elongation factor 1 beta central acidic region |
| EF1_GNE | EF-1 guanine nucleotide exchange domain |
| EF1G | Elongation factor 1 gamma, conserved domain |
| EFG_C | Elongation factor G C-terminus |
| EFG_IV | Elongation factor G, domain IV |
| EFh | EF-hand, calcium binding motif |
| efhand_Ca_insen | Ca2+ insensitive EF hand |
| EFP | Elongation factor P (EF-P) OB domain |
| EGF | Epidermal growth factor-like domain. |
| EGF_CA | Calcium-binding EGF-like domain |
| EGF_Lam | Laminin-type epidermal growth factor-like domai |
| EGF_like | EGF domain, unclasssified subfamily |
| EH | Eps15 homology domain |
| eIF-5a | Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold |
| eIF1a | eukaryotic translation initiation factor 1A |
| eIF2B_5 | domain present in translation initiation factor eIF2B and eIF5 |
| eIF3_N | eIF3 subunit 6 N terminal domain |
| eIF5C | Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5 |
| eIF6 | translation initiation factor 6 |
| EKR | Domain of unknown function |
| ELFV_dehydrog | Glutamate/Leucine/Phenylalanine/Valine dehydrogenase |
| Elicitin | |
| ELK | |
| ELM2 | |
| Elong-fact-P_C | Elongation factor P, C-terminal |
| Elp3 | Elongator protein 3, MiaB family, Radical SAM |
| EMP24_GP25L | emp24/gp25L/p24 family/GOLD |
| END | Endothelin |
| ENDO3c | endonuclease III |
| Endonuclease_NS | DNA/RNA non-specific endonuclease |
| Enolase_C | Enolase, C-terminal TIM barrel domain |
| Enolase_N | Enolase, N-terminal domain |
| ENT | |
| ENTH | Epsin N-terminal homology (ENTH) domain |
| EPEND | Ependymins |
| EPH_lbd | Ephrin receptor ligand binding domain |
| Ephrin_rec_like | Putative ephrin-receptor like |
| ERCC4 | ERCC4 domain |
| eRF1_1 | |
| EsV_1_7 | EsV-1-7 repeat |
| ETF | Electron transfer flavoprotein domain |
| ETS | erythroblast transformation specific domain |
| Excalibur | Excalibur calcium-binding domain |
| EXOIII | |
| EZ_HEAT | E-Z type HEAT repeats |
| FA | FERM adjacent (FA) |
| FA58C | Coagulation factor 5/8 C-terminal domain, discoidin domain |
| FABD | F-actin binding domain (FABD) |
| FACT-Spt16_Nlob | FACT complex subunit SPT16 N-terminal lobe domain |
| FANCL_C | FANCL C-terminal domain |
| Fapy_DNA_glyco | Formamidopyrimidine-DNA glycosylase N-terminal domain |
| FAS1 | Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. |
| FATC | |
| FBA | F-box associated region |
| FBD | domain in FBox and BRCT domain containing plant proteins |
| FBG | Fibrinogen-related domains (FReDs) |
| FBOX | A Receptor for Ubiquitination Targets |
| fCBD | Fungal-type cellulose-binding domain |
| FCD | |
| FCH | Fes/CIP4 homology domain |
| FDF | |
| FDX-ACB | Ferredoxin-fold anticodon binding domain |
| Fe_hyd_SSU | Iron hydrogenase small subunit |
| FeoA | |
| FerA | |
| FerB | |
| FerI | |
| FERM_C | FERM C-terminal PH-like domain |
| FES | |
| FF | Contains two conserved F residues |
| FGF | Acidic and basic fibroblast growth factor family. |
| FH | FORKHEAD |
| FH2 | Formin Homology 2 Domain |
| FHA | Forkhead associated domain |
| Fib_alpha | Fibrinogen alpha/beta chain family |
| Fibrillarin | |
| Filament | Intermediate filament protein |
| FIMAC | factor I membrane attack complex |
| FISNA | Fish-specific NACHT associated domain |
| FIST | FIST N domain |
| FIST_C | |
| FKS1_dom1 | 1,3-beta-glucan synthase subunit FKS1 |
| Flavin_Reduct | Flavin reductase like domain |
| Flavokinase | Riboflavin kinase |
| Flo11 | |
| Flu_M1_C | Influenza Matrix protein (M1) C-terminal domain |
| FMN_bind | |
| Fmp27_GFWDK | RNA pol II promoter Fmp27 protein domain |
| Fmp27_SW | RNA pol II promoter Fmp27 protein domain |
| Fmp27_WPPW | RNA pol II promoter Fmp27 protein domain Provide feedback |
| FN1 | Fibronectin type 1 domain |
| FN2 | Fibronectin type 2 domain |
| FN3 | Fibronectin type 3 domain |
| Fn3_like | Fibronectin type III-like domain |
| FolB | Dihydroneopterin aldolase |
| FOLN | Follistatin-N-terminal domain-like |
| FoP_duplication | C-terminal duplication domain of Friend of PRMT1 |
| Frataxin_Cyay | Frataxin-like domain |
| FRG | |
| FRI | Frizzled |
| Frizzled | Frizzled/Smoothened family membrane region |
| FSA_C | Fragile site-associated protein C-terminus |
| FTCD | Formiminotransferase domain |
| FTCD_N | Formiminotransferase domain, N-terminal subdomain |
| FTO_NTD | FTO catalytic domain |
| FTP | eel-Fucolectin Tachylectin-4 Pentaxrin-1 Domain |
| FtsA | Cell division protein FtsA |
| Ftsk_gamma | |
| FU | Furin-like repeats |
| Fungal_trans | Fungal specific transcription factor domain |
| FYRC | "FY-rich" domain, C-terminal region |
| FYRN | "FY-rich" domain, N-terminal region |
| FYVE | Protein present in Fab1, YOTB, Vac1, and EEA1 |
| G2F | G2 nidogen domain and fibulin |
| G3P_acyltransf | Glycerol-3-phosphate acyltransferase |
| G5 | |
| G8 | |
| G_alpha | G protein alpha subunit |
| G_gamma | GGL domain |
| G_patch | glycine rich nucleic binding domain |
| GA | GA module |
| GAF | Domain present in phytochromes and cGMP-specific phosphodiesterases. |
| GAGA_bind | GAGA binding protein-like family |
| GAGE | |
| Gal-bind_lectin | Galactoside-binding lectin |
| GAL4 | GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain |
| Galanin | Galanin |
| GARS_A | Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain |
| GARS_C | Phosphoribosylglycinamide synthetase, C domain |
| GAS2 | Growth-Arrest-Specific Protein 2 Domain |
| GASTRIN | gastrin / cholecystokinin / caerulein family |
| GATase_5 | CobB/CobQ-like glutamine amidotransferase domain |
| GatB_Yqey | GatB domain |
| GCK | |
| GDNF | GDNF/GAS1 domain |
| GED | Dynamin GTPase effector domain |
| GEL | Gelsolin homology domain |
| Gemini_AL1 | HUH phage replication sub-family |
| Germane | Sporulation and spore germination |
| GGDEF | diguanylate cyclase |
| GGL | G protein gamma subunit-like motifs |
| GHA | Glycoprotein hormone alpha chain homologues. |
| GHB | Glycoprotein hormone beta chain homologues. |
| GIDA_assoc_3 | GidA associated domain 3 |
| GIT | Helical motif in the GIT family of ADP-ribosylation factor GTPase-activating proteins |
| GIYc | GIY-YIG type nucleases (URI domain) |
| GLA | Domain containing Gla (gamma-carboxyglutamate) residues. |
| GLECT | Galectin |
| Gln-synt_C | Glutamine synthetase, catalytic domain |
| GLUCA | Glucagon like hormones |
| GluR_Homer-bdg | |
| Glyco_10 | Glycosyl hydrolase family 10 |
| Glyco_18 | |
| Glyco_25 | Glycosyl hydrolases family 25 |
| Glyco_32 | Glycosyl hydrolases family 32 |
| GoLoco | LGN motif, putative GEFs specific for G-alpha GTPases |
| Gp_dh_N | Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain |
| GPS | G-protein-coupled receptor proteolytic site domain |
| GRAM | domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins |
| GRAN | Granulin |
| Grip | golgin-97, RanBP2alpha,Imh1p and p230/golgin-245 |
| GS | GS motif |
| GuKc | Guanylate kinase homologues. |
| GYF | Contains conserved Gly-Tyr-Phe residues |
| GYR | Motif of unknown function with conserved Gly, Tyr, Arg tripeptide in Drosophila proteins. |
| H-kinase_dim | Signal transducing histidine kinase, homodimeric domain |
| H15 | Domain in histone families 1 and 5 |
| H2A | Histone 2A |
| H2B | Histone H2B |
| H2TH | Formamidopyrimidine-DNA glycosylase H2TH domain |
| H3 | Histone H3 |
| H4 | Histone H4 |
| HA2 | Helicase associated domain (HA2) Add an annotation |
| HABP4_PAI-RBP1 | Hyaluronan / mRNA binding family |
| Haem_bd | Haem-binding domain |
| Haem_oxygenase_2 | Iron-containing redox enzyme |
| Haemagg_act | haemagglutination activity domain |
| Haemolytic | |
| HALZ | homeobox associated leucin zipper |
| HAMP | HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain |
| HAP1_N | HAP1 N-terminal conserved region |
| HAT | HAT (Half-A-TPR) repeats |
| HATPase_c | Histidine kinase-like ATPases |
| HBM | helical bimodular (HBM) domain |
| HDAC_interact | Histone deacetylase (HDAC) interacting |
| HDc | Metal dependent phosphohydrolases with conserved 'HD' motif. |
| HECTc | Domain Homologous to E6-AP Carboxyl Terminus with |
| HELICc | helicase superfamily c-terminal domain |
| HELICc2 | |
| HELICc3 | |
| HEPN | Higher Eukarytoes and Prokaryotes Nucleotide-binding domain |
| HhH1 | Helix-hairpin-helix DNA-binding motif class 1 |
| HhH2 | Helix-hairpin-helix class 2 (Pol1 family) motifs |
| HintC | Hint (Hedgehog/Intein) domain C-terminal region |
| HintN | Hint (Hedgehog/Intein) domain N-terminal region |
| HIRAN | |
| HisKA | His Kinase A (phosphoacceptor) domain |
| HLH | helix loop helix domain |
| HMG | high mobility group |
| HMG17 | domain in high mobilty group proteins HMG14 and HMG 17 |
| HNHc | HNH nucleases |
| HNS | Domain in histone-like proteins of HNS family |
| HOLI | Ligand binding domain of hormone receptors |
| HormR | Domain present in hormone receptors |
| HOX | Homeodomain |
| HPT | Histidine Phosphotransfer domain |
| Hr1 | Rho effector or protein kinase C-related kinase homology region 1 homologues |
| HRDC | Helicase and RNase D C-terminal |
| HSA | domain in helicases and associated with SANT domains |
| HSF | heat shock factor |
| HTH_ARAC | helix_turn_helix, arabinose operon control protein |
| HTH_ARSR | helix_turn_helix, Arsenical Resistance Operon Repressor |
| HTH_ASNC | helix_turn_helix ASNC type |
| HTH_CRP | helix_turn_helix, cAMP Regulatory protein |
| HTH_DEOR | helix_turn_helix, Deoxyribose operon repressor |
| HTH_DTXR | Helix-turn-helix diphteria tox regulatory element |
| HTH_GNTR | helix_turn_helix gluconate operon transcriptional repressor |
| HTH_ICLR | helix_turn_helix isocitrate lyase regulation |
| HTH_LACI | helix_turn _helix lactose operon repressor |
| HTH_LUXR | helix_turn_helix, Lux Regulon |
| HTH_MARR | helix_turn_helix multiple antibiotic resistance protein |
| HTH_MERR | helix_turn_helix, mercury resistance |
| HTH_XRE | Helix-turn-helix XRE-family like proteins |
| HTTM | Horizontally Transferred TransMembrane Domain |
| HUH | virus and plasmid replication protein with conserved HXH motif |
| huh_y1 | HUH transposase Y1 type |
| huh_y2 | HUH transposase Y2 type |
| HWE_HK | HWE histidine kinase |
| HX | Hemopexin-like repeats. |
| HYDRO | Hydrophobins |
| IB | Insulin growth factor-binding protein homologues |
| IBN_N | Importin-beta N-terminal domain |
| IBR | In Between Ring fingers |
| ICA69 | Islet cell autoantigen ICA69, C-terminal domain |
| IDEAL | |
| IENR1 | Intron encoded nuclease repeat motif |
| IENR2 | Intron-encoded nuclease repeat 2 |
| IFabd | Interferon alpha, beta and delta. |
| IG | Immunoglobulin |
| IG_FLMN | Filamin-type immunoglobulin domains |
| IG_like | Immunoglobulin like |
| IGc1 | Immunoglobulin C-Type |
| IGc2 | Immunoglobulin C-2 Type |
| IGR | |
| IGv | Immunoglobulin V-Type |
| IKKbetaNEMObind | I-kappa-kinase-beta NEMO binding domain |
| IL1 | Interleukin-1 homologues |
| IL10 | Interleukin-10 family |
| IL2 | Interleukin-2 family |
| IL4_13 | Interleukins 4 and 13 |
| IL6 | Interleukin-6 homologues |
| IL7 | Interleukin-7 and interleukin-9 family. |
| IlGF | Insulin / insulin-like growth factor / relaxin family. |
| ILWEQ | I/LWEQ domain |
| IMPDH | IMP dehydrogenase / GMP reductase domain |
| INB | Integrin beta subunits (N-terminal portion of extracellular region) |
| ING | Inhibitor of growth proteins N-terminal histone-binding |
| Inhibitor_I29 | Cathepsin propeptide inhibitor domain (I29) |
| Int_alpha | Integrin alpha (beta-propellor repeats). |
| Int_BPP-1 | sub-family of tyrosine recombinases |
| Int_Brujita | sub-family of tyrosine recombinases |
| Int_CTnDOT | sub-family of tyrosine recombinases |
| Int_Des | sub-family of tyrosine recombinases |
| Int_P2 | sub-family of tyrosine recombinases |
| Int_SXT | sub-family of tyrosine recombinases |
| Int_Tn916 | sub-family of tyrosine recombinases |
| Integrin_b_cyt | |
| Integrin_B_tail | |
| Integron | sub-family of tyrosine recombinases |
| IntKX | sub-family of tyrosine recombinases |
| IPPc | Inositol polyphosphate phosphatase, catalytic domain homologues |
| IPT | ig-like, plexins, transcription factors |
| IQ | Short calmodulin-binding motif containing conserved Ile and Gln residues. |
| IRF | interferon regulatory factor |
| IRF-3 | Interferon-regulatory factor 3 |
| IRO | Motif in Iroquois-class homeodomain proteins (only). Unknown function. |
| IRS | Phosphotyrosine-binding domain |
| Iso_dh | Isocitrate/isopropylmalate dehydrogenase |
| ITAM | Immunoreceptor tyrosine-based activation motif |
| JAB_MPN | JAB/MPN domain |
| Jacalin | Jacalin-like lectin domain |
| Jag_N | |
| JHBP | Juvenile hormone binding protein domains in insects. |
| JmjC | A domain family that is part of the cupin metalloenzyme superfamily. |
| JmjN | Small domain found in the jumonji family of transcription factors |
| Josephin | |
| K167R | K167/Chmadrin repeat |
| KaiA | |
| KaiB | |
| KAP | Kinesin-associated protein (KAP) |
| KapB | |
| KASH | Nuclear envelope localisation domain |
| KAT11 | Histone acetylation protein |
| KAZAL | Kazal type serine protease inhibitors |
| KbaA | KinB-signalling pathway activation in sporulation |
| Kelch | |
| KH | K homology RNA-binding domain |
| KilA-N | |
| Kin17_mid | Domain of Kin17 curved DNA-binding protein |
| KIND | kinase non-catalytic C-lobe domain |
| KISc | Kinesin motor, catalytic domain. ATPase. |
| KLRAQ | Predicted coiled-coil domain-containing protein |
| Knot1 | Knottins |
| KNOX1 | |
| KNOX2 | |
| KOW | KOW (Kyprides, Ouzounis, Woese) motif. |
| KR | Kringle domain |
| KRAB | krueppel associated box |
| KRAP_IP3R_bind | Ki-ras-induced actin-interacting protein-IP3R-interacting domain |
| KRBA1 | KRBA1 family repeat |
| KU | BPTI/Kunitz family of serine protease inhibitors. |
| Ku78 | Ku70 and Ku80 are 70kDa and 80kDa subunits of the Lupus Ku autoantigen |
| L27 | domain in receptor targeting proteins Lin-2 and Lin-7 |
| L51_S25_CI-B8 | Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain |
| LA | Domain in the RNA-binding Lupus La protein; unknown function |
| LAB_N | Lipid A Biosynthesis N-terminal domain |
| Lactamase_B | Metallo-beta-lactamase superfamily |
| LAG1_DNAbind | LAG1, DNA binding |
| LamB | Laminin B domain |
| LamG | Laminin G domain |
| LamGL | LamG-like jellyroll fold domain |
| LamNT | Laminin N-terminal domain (domain VI) |
| LAMTOR | Late endosomal/lysosomal adaptor and MAPK and MTOR activator |
| LANC_like | Lanthionine synthetase C-like protein |
| LCCL | |
| LDLa | Low-density lipoprotein receptor domain class A |
| LEM | in nuclear membrane-associated proteins |
| LeuA_dimer | LeuA allosteric (dimerisation) domain |
| Leuk-A4-hydro_C | Leukotriene A4 hydrolase, C-terminal |
| LH2 | Lipoxygenase homology 2 (beta barrel) domain |
| LIF_OSM | leukemia inhibitory factor |
| Lig_chan-Glu_bd | Ligated ion channel L-glutamate- and glycine-binding site |
| LIGANc | Ligase N family |
| LIM | Zinc-binding domain present in Lin-11, Isl-1, Mec-3. |
| LINK | Link (Hyaluronan-binding) |
| Lipid_DES | Sphingolipid Delta4-desaturase (DES) |
| LisH | Lissencephaly type-1-like homology motif |
| LITAF | Possible membrane-associated motif in LPS-induced tumor necrosis factor alpha factor (LITAF), also known as PIG7, and other animal proteins. |
| LMWPc | Low molecular weight phosphatase family |
| LNS2 | |
| LON | Found in ATP-dependent protease La (LON) |
| Longin | Regulated-SNARE-like domain |
| LPD_N | Lipoprotein N-terminal Domain |
| LRR | Leucine-rich repeats, outliers |
| LRR_BAC | Leucine-rich repeats, bacterial type |
| LRR_CC | Leucine-rich repeat - CC (cysteine-containing) subfamily |
| LRR_RI | Leucine rich repeat, ribonuclease inhibitor type |
| LRR_SD22 | Leucine-rich repeat, SDS22-like subfamily |
| LRR_TYP | Leucine-rich repeats, typical (most populated) subfamily |
| LRRcap | occurring C-terminal to leucine-rich repeats |
| LRRCT | Leucine rich repeat C-terminal domain |
| LRRNT | Leucine rich repeat N-terminal domain |
| LSM14 | Scd6-like Sm domain |
| LsmAD | |
| LU | Ly-6 antigen / uPA receptor -like domain |
| LY | Low-density lipoprotein-receptor YWTD domain |
| LysM | Lysin motif |
| LytTR | LytTr DNA-binding domain |
| LYZ1 | Alpha-lactalbumin / lysozyme C |
| LYZ2 | Lysozyme subfamily 2 |
| M16C_associated | Peptidase M16C associated |
| M60-like | Peptidase M60-like family |
| MA | Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). |
| MA3 | Domain in DAP-5, eIF4G, MA-3 and other proteins. |
| Mab-21 | |
| Mac | Maltose acetyltransferase |
| MACPF | membrane-attack complex / perforin |
| Mad3_BUB1_I | Mad3/BUB1 hoMad3/BUB1 homology region 1 |
| MADF | |
| MADS | |
| MAGE | Melanoma-associated antigen |
| MAGE_N | Melanoma associated antigen family N terminal |
| Mago-bind | Mago binding |
| MAGUK_N_PEST | Polyubiquitination (PEST) N-terminal domain of MAGUK |
| malic | Malic enzyme, N-terminal domain |
| Malic_M | Malic enzyme, NAD binding domain |
| MAM | Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) |
| MamL-1 | MamL-1 domain |
| MANEC | |
| MAPKK1_Int | Mitogen-activated protein kinase kinase 1 interacting |
| MATH | meprin and TRAF homology |
| Matrilin_ccoil | Trimeric coiled-coil oligomerisation domain of matrilin |
| MBD | Methyl-CpG binding domain |
| MBT | Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2 |
| MbtH | MbtH-like protein |
| MCM | minichromosome maintenance proteins |
| Mcm10 | Mcm10 replication factor |
| MD | |
| Med12 | Transcription mediator complex subunit Med12 |
| MeTrc | Methyltransferase, chemotaxis proteins |
| MGS | MGS-like domain |
| MgtE_N | MgtE intracellular N domain |
| MHC_II_alpha | Class II histocompatibility antigen, alpha domain |
| MHC_II_beta | Class II histocompatibility antigen, beta domain |
| MIF4G | Middle domain of eukaryotic initiation factor 4G (eIF4G) |
| Milton | Kinesin associated protein |
| MIR | Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases |
| MIT | Microtubule Interacting and Trafficking molecule domain |
| ML | Domain involved in innate immunity and lipid metabolism. |
| MltA | MltA specific insert domain |
| Mob1_phocein | Mob1/phocein family |
| Mob_Pre | HUH conjugative element mobility domain |
| MobA_MobL | HUH conjugative element mobility domain |
| MoCF_biosynth | Probable molybdopterin binding domain |
| Molybdop_Fe4S4 | Molybdopterin oxidoreductase Fe4S4 domain |
| MORN | Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases. |
| MR_MLE | Mandelate racemase / muconate lactonizing enzyme, C-terminal domain |
| Mre11_DNA_bind | Mre11 DNA-binding presumed domain |
| Mterf | Mitochondrial termination factor repeats |
| MutH | DNA mismatch repair enzyme MutH |
| MutL_C | MutL C terminal dimerisation domain |
| MUTSac | ATPase domain of DNA mismatch repair MUTS family |
| MUTSd | DNA-binding domain of DNA mismatch repair MUTS family |
| Myc | sub-family of tyrosine recombinases |
| MYSc | Myosin. Large ATPases. |
| MyTH4 | Domain in Myosin and Kinesin Tails |
| N-glycanase_N | Peptide-N-glycosidase F, N terminal |
| N-SET | COMPASS (Complex proteins associated with Set1p) component N |
| N1221 | N1221-like protein |
| N2227 | |
| NAC | |
| NADH-G_4Fe-4S_3 | NADH-ubiquinone oxidoreductase-G iron-sulfur binding region |
| NADH_4Fe-4S | NADH-ubiquinone oxidoreductase-F iron-sulfur binding region |
| NAT_PEP | Natriuretic peptide |
| Nbs1_C | DNA damage repair protein Nbs1 |
| NDK | |
| NEAT | NEAr Transporter domain |
| NEBU | |
| NEUZ | |
| Nfu_N | Scaffold protein Nfu/NifU N terminal |
| NGF | Nerve growth factor (NGF or beta-NGF) |
| NGN | In Spt5p, this domain may confer affinity for Spt4p. It possesses a RNP-like fold. |
| NH | Neurohypophysial hormones |
| NIDO | Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins. |
| NIL | |
| NL | Domain found in Notch and Lin-12 |
| NMU | Neuromedin U |
| NOD | |
| NODP | |
| NOSIC | NOSIC (NUC001) domain |
| NPCBM | |
| NPP | Pro-opiomelanocortin, N-terminal region |
| NRF | N-terminal domain in C. elegans NRF-6 (Nose Resistant to Fluoxetine-4) and NDG-4 (resistant to nordihydroguaiaretic acid-4). |
| NTR | Tissue inhibitor of metalloproteinase family. |
| NUC | DNA/RNA non-specific endonuclease |
| NUC194 | |
| NurA | |
| OLF | Olfactomedin-like domains |
| OMPdecase | Orotidine 5'-phosphate decarboxylase / HUMPS family |
| OmpH | Outer membrane protein (OmpH-like) |
| Op_neuropeptide | Opioids neuropeptide |
| ORANGE | Orange domain |
| OrfB_IS605 | DDE transposase sub-family |
| OSTEO | Osteopontin |
| P-II | Nitrogen regulatory protein P-II |
| P4Hc | Prolyl 4-hydroxylase alpha subunit homologues. |
| P68HR | P68HR (NUC004) repeat |
| PA14 | |
| PA2c | Phospholipase A2 |
| PAC | Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) |
| PADR1 | |
| PAH | Pancreatic hormones / neuropeptide F / peptide YY family |
| PAM | PCI/PINT associated module |
| PAN_AP | divergent subfamily of APPLE domains |
| PAPA-1 | |
| ParB | ParB-like nuclease domain |
| PAS | PAS domain |
| PASTA | |
| PAW | domain present in PNGases and other hypothetical proteins |
| PAX | Paired Box domain |
| PAZ | |
| PB1 | PB1 domain |
| PBD | P21-Rho-binding domain |
| PbH1 | Parallel beta-helix repeats |
| PBP5_C | Penicillin-binding protein 5, C-terminal domain |
| PBPb | Bacterial periplasmic substrate-binding proteins |
| PBPe | Eukaryotic homologues of bacterial periplasmic substrate binding proteins. |
| PCRF | |
| PD | P or trefoil or TFF domain |
| PDDEXK | PD-(D/E)XK nuclease transposase |
| PDDEXK_2 | PD-(D/E)XK nuclease transposase sub-family |
| PDGF | Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family |
| PDZ | Domain present in PSD-95, Dlg, and ZO-1/2. |
| PEHE | |
| Pept_C1 | Papain family cysteine protease |
| PepX_C | X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain |
| PepX_N | X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal |
| PGA_cap | Bacterial capsule synthesis protein PGA_cap |
| PGAM | Phosphoglycerate mutase family |
| PGRP | Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme. |
| PH | Pleckstrin homology domain. |
| Phage_GPA | HUH phage replication sub-family |
| Phage_integrase | Pfam phage integrase family |
| PHB | prohibitin homologues |
| PhBP | Insect pheromone/odorant binding protein domains. |
| PHD | PHD zinc finger |
| PhnA_Zn_Ribbon | PhnA Zinc-Ribbon |
| PI3K_C2 | Phosphoinositide 3-kinase, region postulated to contain C2 domain |
| PI3K_p85B | PI3-kinase family, p85-binding domain |
| PI3K_rbd | PI3-kinase family, Ras-binding domain |
| PI3Ka | Phosphoinositide 3-kinase family, accessory domain (PIK domain) |
| PI3Kc | Phosphoinositide 3-kinase, catalytic domain |
| PIG-X | PIG-X / PBN1 |
| PINc | Large family of predicted nucleotide-binding domains |
| PINT | motif in proteasome subunits, Int-6, Nip-1 and TRIP-15 |
| PIP49_N | N-term cysteine-rich ER, FAM69 |
| PIPKc | Phosphatidylinositol phosphate kinases |
| Piwi | |
| PKD | Repeats in polycystic kidney disease 1 (PKD1) and other proteins |
| PKS_AT | Acyl transferase domain in polyketide synthase (PKS) enzymes. |
| PKS_DH | |
| PKS_ER | Enoylreductase |
| PKS_KR | |
| PKS_KS | Beta-ketoacyl synthase |
| PKS_MT | Methyltransferase in polyketide synthase (PKS) enzymes. |
| PKS_PP | Phosphopantetheine attachment site |
| PKS_PP_betabranch | |
| PKS_TE | Thioesterase |
| PLAc | Cytoplasmic phospholipase A2, catalytic subunit |
| PLCXc | Phospholipase C, catalytic domain (part); domain X |
| PLCYc | Phospholipase C, catalytic domain (part); domain Y |
| PLDc | Phospholipase D. Active site motifs. |
| PLEC | Plectin repeat |
| PLP | Myelin proteolipid protein (PLP or lipophilin) |
| PlsC | Phosphate acyltransferases |
| Plus3 | Short conserved domain in transcriptional regulators. |
| PMEI | Plant invertase/pectin methylesterase inhibitor |
| POL3Bc | DNA polymerase III beta subunit |
| POLAc | DNA polymerase A domain |
| POLBc | DNA polymerase type-B family |
| POLIIIAc | DNA polymerase alpha chain like domain |
| POLXc | DNA polymerase X family |
| PolyA | C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein. |
| POP4 | A domain found in a protein subunit of human RNase MRP and RNase P ribonucleoprotein complexes and archaeal proteins. |
| PostSET | Cysteine-rich motif following a subset of SET domains |
| POU | Found in Pit-Oct-Unc transcription factors |
| POX | domain associated with HOX domains |
| PP2Ac | Protein phosphatase 2A homologues, catalytic domain. |
| PP2C_SIG | Sigma factor PP2C-like phosphatases |
| PP2Cc | Serine/threonine phosphatases, family 2C, catalytic domain |
| PQQ | beta-propeller repeat |
| PRE_C2HC | |
| PreSET | N-terminal to some SET domains |
| Pribosyltran_N | N-terminal domain of ribose phosphate pyrophosphokinase |
| PriCT_1 | Primase C terminal 1 (PriCT-1) |
| Prim-Pol | Bifunctional DNA primase/polymerase, N-terminal |
| Prim_Zn_Ribbon | Zinc-binding domain of primase-helicase |
| Pro-kuma_activ | Pro-kumamolisin, activation domain |
| Pro-rich | Proline-rich |
| Pro_CA | Carbonic anhydrase |
| PROF | Profilin |
| ProQ | ProQ/FINO family |
| ProRS-C_1 | Prolyl-tRNA synthetase, C-terminal |
| Proteasome_A_N | Proteasome subunit A N-terminal signature Add an annotation |
| PRP | Major prion protein |
| PRY | |
| PSA | Paramecium Surface Antigen Repeat |
| PSI | domain found in Plexins, Semaphorins and Integrins |
| PSN | Presenilin, signal peptide peptidase, family |
| PSP | proline-rich domain in spliceosome associated proteins |
| PTB | Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain |
| PTBI | Phosphotyrosine-binding domain (IRS1-like) |
| PTEN_C2 | C2 domain of PTEN tumour-suppressor protein |
| PTH | Parathyroid hormone |
| PTI | Plant trypsin inhibitors |
| PTN | Pleiotrophin / midkine family |
| PTPc | Protein tyrosine phosphatase, catalytic domain |
| PTPc_DSPc | Protein tyrosine phosphatase, catalytic domain, undefined specificity |
| PTPc_motif | Protein tyrosine phosphatase, catalytic domain motif |
| PTPlike_phytase | Inositol hexakisphosphate |
| PTX | Pentraxin / C-reactive protein / pentaxin family |
| PUA | Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase |
| PUG | domain in protein kinases, N-glycanases and other nuclear proteins |
| Pumilio | Pumilio-like repeats |
| PUR | DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes and the Bacteroides-Cytophaga-Flexibacter bacteria. |
| PWI | PWI, domain in splicing factors |
| PWWP | domain with conserved PWWP motif |
| PX | PhoX homologous domain, present in p47phox and p40phox. |
| PXA | Domain associated with PX domains |
| PYNP_C | Pyrimidine nucleoside phosphorylase C-terminal domain |
| PYRIN | PAAD/DAPIN/Pyrin domain |
| QLQ | |
| R3H | Putative single-stranded nucleic acids-binding domain |
| RA | Ras association (RalGDS/AF-6) domain |
| RAB | Rab subfamily of small GTPases |
| rADc | Ribosomal RNA adenine dimethylases |
| RAN | Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases |
| RanBD | Ran-binding domain |
| RAP | |
| Rapamycin_bind | Rapamycin binding domain |
| Raptor_N | Raptor N-terminal CASPase like domain |
| RAS | Ras subfamily of RAS small GTPases |
| Ras_bdg_2 | Ras-binding domain of Byr2 |
| RasGAP | GTPase-activator protein for Ras-like GTPases |
| RasGEF | Guanine nucleotide exchange factor for Ras-like small GTPases |
| RasGEF_N_2 | Rapamycin-insensitive companion of mTOR RasGEF_N domain |
| RasGEFN | Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif |
| RB_A | Retinoblastoma-associated protein A domain |
| Rb_C | Rb C-terminal domain |
| RBD | Raf-like Ras-binding domain |
| REC | cheY-homologous receiver domain |
| RelA_SpoT | Region found in RelA / SpoT proteins |
| Relaxase | HUH conjugative element mobility domain |
| Rep_1 | HUH conjugative element mobility domain |
| Rep_2 | HUH conjugative element mobility domain |
| Rep_N | HUH phage replication sub-family |
| RES | |
| Resolvase | Resolvase, N terminal domain |
| RESP18 | |
| RFX5_DNA_bdg | RFX5 DNA-binding domain |
| RGS | Regulator of G protein signalling domain |
| RHO | Rho (Ras homology) subfamily of Ras-like small GTPases |
| Rho_N | Rho termination factor, N-terminal domain |
| RHOD | Rhodanese Homology Domain |
| RhoGAP | GTPase-activator protein for Rho-like GTPases |
| RhoGEF | Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases |
| RIBOc | Ribonuclease III family |
| Ribosomal_L14 | Ribosomal protein L14p/L23e |
| Ribosomal_L15e | |
| Ribosomal_L19e | |
| Ribosomal_L2 | Ribosomal Proteins L2, RNA binding domain |
| Ribosomal_L2_C | Ribosomal Proteins L2, C-terminal domain |
| Ribosomal_L31e | |
| Ribosomal_L32e | |
| Ribosomal_L40e | |
| Ribosomal_S10 | Ribosomal protein S10p/S20e |
| Ribosomal_S13_N | Ribosomal S13/S15 N-terminal domain |
| Ribosomal_S15 | |
| Ribosomal_S19e | |
| Ribosomal_S27 | Ribosomal protein S27a |
| Ribosomal_S3Ae | Ribosomal S3Ae family |
| Ribosomal_S4 | Ribosomal protein S4/S9 N-terminal domain |
| Ribosomal_S6e | Ribosomal protein S6e |
| RICIN | Ricin-type beta-trefoil |
| RICTOR_M | Rapamycin-insensitive companion of mTOR, middle domain |
| RICTOR_N | Rapamycin-insensitive companion of mTOR, N-term |
| RICTOR_phospho | Rapamycin-insensitive companion of mTOR, phosphorylation-site |
| RICTOR_V | Rapamycin-insensitive companion of mTOR, domain 5 |
| RIIa | RIIalpha, Regulatory subunit portion of type II PKA R-subunit |
| RING | Ring finger |
| RINGv | The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins. Some of these proteins have been shown both in vivo and in vitro to have ubiquitin E3 ligase activity. |
| RIO | RIO-like kinase |
| RitA | sub-family of tyrosine recombinases |
| RitB | sub-family of tyrosine recombinases |
| RitC | sub-family of tyrosine recombinases |
| RL11 | Ribosomal protein L11/L12 |
| RNA_pol_Rpb6 | RNA polymerase Rpb6 |
| RNAse_Pc | Pancreatic ribonuclease |
| RNB | |
| Robl_LC7 | Roadblock/LC7 domain |
| Romo1 | Reactive mitochondrial oxygen species modulator 1 |
| RPEL | Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2 |
| RPOL4c | DNA-directed RNA-polymerase II subunit |
| RPOL8c | RNA polymerase subunit 8 |
| RPOL9 | RNA polymerase subunit 9 |
| RPOL_N | DNA-directed RNA polymerase N-terminal |
| RPOLA_N | RNA polymerase I subunit A N-terminus |
| RPOLCX | RNA polymerase subunit CX |
| RPOLD | RNA polymerases D |
| RPR | |
| RQC | |
| RRM | RNA recognition motif |
| RRM_1 | RNA recognition motif |
| RRM_2 | RNA recognition motif |
| RTC4 | RTC4-like domain |
| Rtt106 | Histone chaperone Rttp106-like |
| RuBisCO_small | Ribulose bisphosphate carboxylase, small chain |
| RUN | |
| rve | DDE transposase retroviral integrase sub-family |
| rve_2 | DDE transposase retroviral integrase sub-family |
| rve_3 | DDE transposase retroviral integrase sub-family |
| RWD | |
| S1 | Ribosomal protein S1-like RNA-binding domain |
| S4 | S4 RNA-binding domain |
| s48_45 | Sexual stage antigen s48/45 domain |
| S_100 | S-100/ICaBP type calcium binding domain |
| S_TK_X | Extension to Ser/Thr-type protein kinases |
| S_TKc | Serine/Threonine protein kinases, catalytic domain |
| SAA | Serum amyloid A proteins |
| SAF | |
| SAM | Sterile alpha motif. |
| SAM_HD_adjacent | SAM homeodomain adjacent domain |
| SAM_PNT | SAM / Pointed domain |
| SAND | SAND domain |
| SANT | SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains |
| SAP | Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation |
| SAPA | Saposin/surfactant protein-B A-type DOMAIN |
| SapB | Saposin (B) Domains |
| SAR | Sar1p-like members of the Ras-family of small GTPases |
| SARA | Smad anchor for receptor activation (SARA) |
| SATase_N | Serine acetyltransferase, N-terminal |
| SCAN | leucine rich region |
| SCP | SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. |
| SCPU | Spore Coat Protein U domain |
| SCY | Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). |
| Sds3 | Sds3-like |
| SEA | Domain found in sea urchin sperm protein, enterokinase, agrin |
| SEC14 | Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) |
| Sec3-PIP2_bind | Exocyst complex component SEC3 N-terminal PIP2 binding PH |
| Sec63 | Sec63 Brl domain |
| Sec7 | Sec7 domain |
| SecA_DEAD | SecA DEAD-like domain |
| SecA_PP_bind | SecA preprotein cross-linking domain |
| SEL1 | Sel1-like repeats. |
| Sema | semaphorin domain |
| Semialdhyde_dh | Semialdehyde dehydrogenase, NAD binding domain |
| SEP | Domain present in Saccharomyces cerevisiae Shp1, Drosophila melanogaster eyes closed gene (eyc), and vertebrate p47. |
| SER | resolvase domain containing family involved in site-specific recombination |
| ser_ce | serine recombinase conjugative transposon sub-family |
| ser_lsr | large serine recombinase sub-family |
| ser_tn | serine transposase sub-family |
| SERPIN | SERine Proteinase INhibitors |
| SET | SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain |
| SF_P | Pulmonary surfactant proteins |
| SFM | Splicing Factor Motif, present in Prp18 and Pr04 |
| SH2 | Src homology 2 domains |
| SH3 | Src homology 3 domains |
| SH3b | Bacterial SH3 domain homologues |
| ShKT | ShK toxin domain |
| SHR3_chaperone | ER membrane protein SH3 |
| Skp1 | Found in Skp1 protein family |
| Sm | snRNP Sm proteins |
| small_GTPase | Small GTPase of the Ras superfamily; ill-defined subfamily |
| SMC_hinge | SMC proteins Flexible Hinge Domain |
| SMI1_KNR4 | SMI1 / KNR4 family |
| SMR | Small MutS-related domain |
| SnAC | Snf2-ATP coupling, chromatin remodelling complex |
| SNc | Staphylococcal nuclease homologues |
| SO | Somatomedin B -like domains |
| SOCS | suppressors of cytokine signalling |
| SOCS_box | |
| Solute_trans_a | Organic solute transporter Ostalpha |
| Sorb | Sorbin homologous domain |
| Spc7 | Spc7 kinetochore protein |
| Spc7_N | N-terminus of kinetochore NMS complex subunit Spc7 |
| SPEC | Spectrin repeats |
| SPK | |
| Spo7_2_N | Sporulation protein family 7 |
| SPOB_ab | Sporulation initiation phospho-transferase B, C-terminal |
| SpoU_sub_bind | RNA 2'-O ribose methyltransferase substrate binding |
| SpoVT_AbrB | SpoVT / AbrB like domain |
| SprT | SprT homologues. |
| SPRY | Domain in SPla and the RYanodine Receptor. |
| SPT16 | FACT complex subunit (SPT16/CDC68) |
| SPT2 | SPT2 chromatin protein |
| Spt4 | Spt4/RpoE2 zinc finger |
| SR | Scavenger receptor Cys-rich |
| SRA | SET and RING finger associated domain. Domain of unknown function in SET domain containing proteins and in Deinococcus radiodurans DRA1533. |
| SRP54 | SRP54-type protein, GTPase domain |
| SRP54_N | SRP54-type protein, helical bundle domain |
| START | in StAR and phosphatidylcholine transfer protein |
| STAT_int | STAT protein, protein interaction domain |
| STE | STE like transcription factors |
| STI | Soybean trypsin inhibitor (Kunitz) family of protease inhibitors |
| STI1 | Heat shock chaperonin-binding motif. |
| STN | Secretin and TonB N terminus short domain |
| STYKc | Protein kinase; unclassified specificity. |
| SVWC | Single domain von Willebrand factor type C |
| SWAP | Suppressor-of-White-APricot splicing regulator |
| SWIB | SWI complex, BAF60b domains |
| Sybindin | Sybindin-like family |
| SynN | Syntaxin N-terminal domain |
| T5orf172 | |
| t_SNARE | Helical region found in SNAREs |
| TAF | TATA box binding protein associated factor |
| TAFH | TAF homology |
| TAFII55_N | TAFII55 protein conserved region |
| TAN | Telomere-length maintenance and DNA damage repair |
| Tankyrase_bdg_C | Tankyrase binding protein C terminal domain |
| TAP_C | C-terminal domain of vertebrate Tap protein |
| TarH | Homologues of the ligand binding domain of Tar |
| TBC | Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. |
| Tbf5 | Transcription factor TFIIH complex subunit Tfb5 |
| TBOX | Domain first found in the mice T locus (Brachyury) protein |
| TDU | Short repeats in human TONDU, fly vestigial and other proteins. |
| TEA | TEA domain |
| TECPR | Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins. |
| Telo_bind | Telomeric single stranded DNA binding POT1/CDC13 |
| Telomerase_RBD | Telomerase ribonucleoprotein complex - RNA binding domain |
| Tet_JBP | Oxygenase domain of the 2OGFeDO superfamily |
| TFIIA | Transcription factor IIA, alpha/beta subunit |
| TFIIE | Transcription initiation factor IIE |
| TFS2M | Domain in the central regions of transcription elongation factor S-II (and elsewhere) |
| TFS2N | Domain in the N-terminus of transcription elongation factor S-II (and elsewhere) |
| TGc | Transglutaminase/protease-like homologues |
| TGFB | Transforming growth factor-beta (TGF-beta) family |
| THAP | |
| THEG | Repeats in THEG (testicular haploid expressed gene) and several fly proteins. |
| Thiol-ester_cl | Alpha-macro-globulin thiol-ester bond-forming region |
| THN | Thaumatin family |
| THUMP | |
| THY | Thymosin beta actin-binding motif. |
| Thymopoietin | |
| TIFY | |
| TilS_C | TilS substrate C-terminal domain |
| Tim44 | |
| TIR | Toll - interleukin 1 - resistance |
| TK | Tachykinin family |
| TLC | TRAM, LAG1 and CLN8 homology domains. |
| TLDc | domain in TBC and LysM domain containing proteins |
| Tn7_Tnp_TnsA_N | PD-(D/E)XK nuclease transposase sub-family |
| TNF | Tumour necrosis factor family. |
| TNFR | Tumor necrosis factor receptor / nerve growth factor receptor repeats. |
| TnpA | sub-family of tyrosine recombinases |
| TnpR | sub-family of tyrosine recombinases |
| TOG | |
| TOP1Ac | Bacterial DNA topoisomerase I DNA-binding domain |
| TOP1Bc | Bacterial DNA topoisomeraes I ATP-binding domain |
| TOP2c | TopoisomeraseII |
| TOP4c | DNA Topoisomerase IV |
| TOPEUc | DNA Topoisomerase I (eukaryota) |
| TOPRIM | |
| Tower | |
| TPK_B1_binding | Thiamin pyrophosphokinase, vitamin B1 binding domain |
| TPR | Tetratricopeptide repeats |
| TR_FER | Transferrin |
| TR_THY | Transthyretin |
| Trans_reg_C | Transcriptional regulatory protein, C terminal |
| Transket_pyr | Transketolase, pyrimidine binding domain |
| Transposase_20 | transposase sub-family |
| Transposase_21 | DDE transposase sub-family |
| Transposase_31 | PD-(D/E)XK nuclease transposase sub-family |
| Transposase_mut | DDE transposase sub-family |
| TRASH | metallochaperone-like domain |
| TRCF | |
| tRNA_SAD | Threonyl and Alanyl tRNA synthetase second additional domain |
| TRP_2 | Transient receptor ion channel II |
| TRP_N | ML-like domain |
| TrwC | HUH conjugative element mobility domain |
| Tryp_SPc | Trypsin-like serine protease |
| TSP1 | Thrombospondin type 1 repeats |
| TSPc | tail specific protease |
| TSPN | Thrombospondin N-terminal -like domains. |
| Tubulin | Tubulin/FtsZ family, GTPase domain |
| Tubulin_C | Tubulin/FtsZ family, C-terminal domain |
| TUDOR | Tudor domain |
| TY | Thyroglobulin type I repeats. |
| TYR | family involved in site-specific recombination, contains conserved tyrosine residue invovled in catalysis |
| TyrKc | Tyrosine kinase, catalytic domain |
| UAS | |
| UBA | Ubiquitin associated domain |
| UBA_e1_C | Ubiquitin-activating enzyme e1 C-terminal domain |
| UBCc | Ubiquitin-conjugating enzyme E2, catalytic domain homologues |
| Ubox | Modified RING finger domain |
| UBQ | Ubiquitin homologues |
| UBX | Domain present in ubiquitin-regulatory proteins |
| uDENN | Domain always found upstream of DENN domain, found in a variety of signalling proteins |
| UDG | Uracil DNA glycosylase superfamily |
| UDPG_MGDP_dh_C | UDP binding domain |
| UIM | Ubiquitin-interacting motif. |
| UME | Domain in UVSB PI-3 kinase, MEI-41 and ESR-1 |
| UreE_C | UreE urease accessory protein, C-terminal domain |
| UreE_N | UreE urease accessory protein, N-terminal domain |
| UTG | Uteroglobin |
| UTRA | |
| V4R | |
| VHP | Villin headpiece domain |
| VHS | Domain present in VPS-27, Hrs and STAM |
| Viral_Rep | HUH phage replication sub-family |
| VIT | Vault protein Inter-alpha-Trypsin domain |
| VKc | |
| VPS10 | |
| VPS9 | Domain present in VPS9 |
| VRR_NUC | |
| VWA | von Willebrand factor (vWF) type A domain |
| VWC | von Willebrand factor (vWF) type C domain |
| VWC_def | |
| VWC_out | von Willebrand factor (vWF) type C domain |
| VWD | von Willebrand factor (vWF) type D domain |
| WAP | Four-disulfide core domains |
| WD40 | WD40 repeats |
| WGR | Proposed nucleic acid binding domain |
| WH1 | WASP homology region 1 |
| WH2 | Wiskott Aldrich syndrome homology region 2 |
| WHEP-TRS | |
| WHy | Water Stress and Hypersensitive response |
| WIF | Wnt-inhibitory factor-1 like domain |
| WNT1 | found in Wnt-1 |
| WR1 | Worm-specific repeat type 1 |
| WRKY | DNA binding domain |
| WSC | present in yeast cell wall integrity and stress response component proteins |
| WSN | Worm-specific (usually) N-terminal domain |
| WW | Domain with 2 conserved Trp (W) residues |
| WWE | Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis. |
| X8 | Possibly involved in carbohydrate binding |
| Xer | sub-family of tyrosine recombinases |
| XPGI | Xeroderma pigmentosum G I-region |
| XPGN | Xeroderma pigmentosum G N-region |
| XTALbg | Beta/gamma crystallins |
| Y1_Tnp | Transposase IS200 like |
| YaeQ | |
| YajC | Preprotein translocase subunit |
| YARHG | |
| YccV-like | Hemimethylated DNA-binding protein YccV like |
| YceI | YceI-like domain |
| YL1_C | YL1 nuclear protein C-terminal domain |
| YqgFc | Likely ribonuclease with RNase H fold. |
| Zalpha | Z-DNA-binding domain in adenosine deaminases. |
| Zds_C | Activator of mitotic machinery Cdc14 phosphatase activation C-term |
| zf-3CxxC | Zinc-binding domain |
| zf-AD | Zinc-finger associated domain (zf-AD) |
| zf-C4_ClpX | ClpX C4-type zinc finger |
| zf-PARP | Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region |
| ZipA_C | ZipA, C-terminal domain (FtsZ-binding) |
| ZM | ZASP-like motif |
| Zn_dep_PLPC | Zinc dependent phospholipase C (alpha toxin) |
| Zn_pept | |
| ZnF_A20 | A20-like zinc fingers |
| ZnF_AN1 | AN1-like Zinc finger |
| ZnF_BED | BED zinc finger |
| ZnF_C2C2 | C2C2 Zinc finger |
| ZnF_C2H2 | zinc finger |
| ZnF_C2HC | zinc finger |
| ZnF_C3H1 | zinc finger |
| ZnF_C4 | c4 zinc finger in nuclear hormone receptors |
| ZnF_CDGSH | CDGSH-type zinc finger. Function unknown. |
| ZnF_CHCC | zinc finger |
| ZnF_DBF | Zinc finger in DBF-like proteins |
| ZnF_GATA | zinc finger binding to DNA consensus sequence [AT]GATA[AG] |
| ZnF_NFX | |
| ZnF_PMZ | plant mutator transposase zinc finger |
| ZnF_Rad18 | Rad18-like CCHC zinc finger |
| ZnF_RBZ | Zinc finger domain |
| ZnF_TAZ | TAZ zinc finger, present in p300 and CBP |
| ZnF_TTF | |
| ZnF_U1 | U1-like zinc finger |
| ZnF_UBP | Ubiquitin Carboxyl-terminal Hydrolase-like zinc finger |
| ZnF_UBR1 | Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway |
| ZnF_ZZ | Zinc-binding domain, present in Dystrophin, CREB-binding protein. |
| ZnMc | Zinc-dependent metalloprotease |
| ZP | Zona pellucida (ZP) domain |
| Zpr1 | Duplicated domain in the epidermal growth factor- and elongation factor-1alpha-binding protein Zpr1. Also present in archaeal proteins. |
| ZU5 | Domain present in ZO-1 and Unc5-like netrin receptors |
SMART MODE:
NORMAL GENOMIC
Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937