14_3_314-3-3 homologues
35EXOc3'-5' exonuclease
4.1mputative band 4.1 homologues' binding motif
53EXOc5'-3' exonuclease
6PGD6-phosphogluconate dehydrogenase, C-terminal domain
7TM_GPCR_SrsxSerpentine type 7TM GPCR chemoreceptor Srsx
A1ppAppr-1"-p processing enzyme
A2MAlpha-2-macroglobulin family
A2M_recepA-macroglobulin receptor
A4_EXTRAamyloid A4
A_amylase_inhibAlpha amylase inhibitor
AAAATPases associated with a variety of cellular activities
AAA_PrkAPrkA AAA domain
AAIPlant lipid transfer protein / seed storage protein / trypsin-alpha amylase inhibitor domain family
AamyAlpha-amylase domain
AARP2CNAARP2CN (NUC121) domain
acidPPcAcid phosphatase homologues
ACRADAM Cysteine-Rich Domain
ACTH_domainCorticotropin ACTH domain
ADAnticodon-binding domain
Ad_cyc_g-alphaAdenylate cyclase G-alpha binding domain
ADEAMctRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
Adenylsucc_syntAdenylosuccinate synthetase
ADFActin depolymerisation factor/cofilin -like domains
AdoHcyaseS-adenosyl-L-homocysteine hydrolase
AdoHcyase_NADS-adenosyl-L-homocysteine hydrolase, NAD binding domain
ADSL_CAdenylosuccinate lyase C-terminus
AerolysinAerolysin toxin
AFOR_NAldehyde ferredoxin oxidoreductase, N-terminal domain
AgenetTudor-like domain present in plant sequences.
AgoutiAgouti protein
AgrBAccessory gene regulator B
AgrDStaphylococcal AgrD protein
Agro_virD5Agrobacterium VirD5 protein
AGTRAPAngiotensin II, type I receptor-associated protein
Aha1_NActivator of Hsp90 ATPase, N-terminal
AHS1Allophanate hydrolase subunit 1
AHS2Allophanate hydrolase subunit 2
AIF_CApoptosis-inducing factor, mitochondrion-associated, C-term
AIP3Actin interacting protein 3
AIRCAIR carboxylase
AKAP_110A-kinase anchor protein 110 kDa
Ala_racemase_CAlanine racemase, C-terminal domain
ALADDelta-aminolevulinic acid dehydratase
AlaDh_PNT_CAlanine dehydrogenase/PNT, C-terminal domain
AlaDh_PNT_NAlanine dehydrogenase/PNT, N-terminal domain
ALBUMINserum albumin
AlcBSiderophore biosynthesis protein domain
Ald_Xan_dh_CAldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
Aldolase_IIClass II Aldolase and Adducin N-terminal domain
AlkA_NAlkA N-terminal domain
alkPPcAlkaline phosphatase homologues
Alpha-amyl_C2Alpha-amylase C-terminal beta-sheet domain
Alpha-L-AF_CAlpha-L-arabinofuranosidase C-terminus
Alpha-mann_midAlpha mannosidase, middle domain
Alpha_adaptinC2Adaptin C-terminal domain
Alpha_kinaseAlpha-kinase family
Alpha_TIFAlpha trans-inducing protein (Alpha-TIF)
AMA-1Apical membrane antigen 1
Amb_V_allergenAmb V Allergen
AmelinAmeloblastin precursor (Amelin)
AMOPAdhesion-associated domain present in MUC4 and other proteins
AMP_NAminopeptidase P, N-terminal domain
AMPKBI5'-AMP-activated protein kinase beta subunit, interation domain
ANATOAnaphylatoxin homologous domain
ANKankyrin repeats
Antimicrobial21Plant antimicrobial peptide
ANXAnnexin repeats
AP2DNA-binding domain in plant proteins such as APETALA2 and EREBPs
AP2EcAP endonuclease family 2
AP3B1_CClathrin-adaptor complex-3 beta-1 subunit C-terminal
AP4E_app_platfAdaptin AP4 complex epsilon appendage platform
APC10Anaphase-promoting complex, subunit 10 (APC10)
APC2Anaphase promoting complex (APC) subunit 2
APCDDCAdenomatosis polyposis coli down-regulated 1
AraC_E_bindBacterial transcription activator, effector binding domain
Arch1sub-family of tyrosine recombinases
Arch2sub-family of tyrosine recombinases
ARFARF-like small GTPases; ARF, ADP-ribosylation factor
ArfaptinArfaptin-like domain
ArfGapPutative GTP-ase activating proteins for the small GTPase, ARF
Arg_tRNA_synt_NArginyl tRNA synthetase N terminal dom
ARIDARID/BRIGHT DNA binding domain
ARMArmadillo/beta-catenin-like repeats
Arrestin_CArrestin (or S-antigen), C-terminal domain
Aspzincin_M35Lysine-specific metallo-endopeptidase
AT_hookDNA binding domain with preference for A/T rich regions
AutotransporterAutotransporter beta-domain
AWSassociated with SET domains
AXHdomain in Ataxins and HMG containing proteins
B12-binding_2B12 binding domain
B2-adapt-app_CBeta2-adaptin appendage, C-terminal sub-domain
B3B3 DNA binding domain
B3_4B3/4 domain
B41Band 4.1 homologues
B5tRNA synthetase B5 domain
B561Cytochrome b-561 / ferric reductase transmembrane domain.
B_lectinBulb-type mannose-specific lectin
Bac_DnaA_CBacterial dnaA protein helix-turn-helix domain
Bac_rhodopsinBacteriorhodopsin-like protein
BACKBTB And C-terminal Kelch
BAFBarrier to autointegration factor
BAGBAG domains, present in regulator of Hsp70 proteins
BAHBromo adjacent homology domain
BASICBasic domain in HLH proteins of MYOD family
BATSBiotin and Thiamin Synthesis associated domain
BBCB-Box C-terminal domain
BBOXB-Box-type zinc finger
BC10Bladder cancer-related protein BC10
BCLBCL (B-Cell lymphoma); contains BH1, BH2 regions
BeachBeige/BEACH domain
Bet_v_1Pathogenesis-related protein Bet v I family
Beta-CaspBeta-Casp domain
Beta-TrCP_DD domain of beta-TrCP
BetaGal_dom2Beta-galactosidase, domain 2
Bgal_small_NBeta galactosidase small chain
BH4BH4 Bcl-2 homology region 4
BHD_1Rad4 beta-hairpin domain 1
BHD_2Rad4 beta-hairpin domain 2
BHD_3Rad4 beta-hairpin domain 3
BHLbacterial (prokaryotic) histone like domain
BID_1Bacterial Ig-like domain (group 1)
BID_2Bacterial Ig-like domain 2
BING4CTBING4CT (NUC141) domain
Biotin_carb_CBiotin carboxylase C-terminal domain
BIRBaculoviral inhibition of apoptosis protein repeat
BLUFSensors of blue-light using FAD
BLVRBovine leukaemia virus receptor (BLVR)
BONbacterial OsmY and nodulation domain
BOP1NTBOP1NT (NUC169) domain
BowBBowman-Birk type proteinase inhibitor
BP28CTBP28CT (NUC211) domain
BPI1BPI/LBP/CETP N-terminal domain
BPI2BPI/LBP/CETP C-terminal domain
BRCTbreast cancer carboxy-terminal domain
BRIGHTBRIGHT, ARID (A/T-rich interaction domain) domain
BRKdomain in transcription and CHROMO domain helicases
BRLZbasic region leucin zipper
Bro-NBRO family, N-terminal domain
BRO1BRO1-like domain
BROMObromo domain
Brr6_like_C_CDi-sulfide bridge nucleocytoplasmic transport domain
BSDdomain in transcription factors and synapse-associated proteins
BTADBacterial transcriptional activator domain
BTBBroad-Complex, Tramtrack and Bric a brac
BTDBeta-trefoil DNA-binding domain
btg1tob/btg1 family
BTKBruton's tyrosine kinase Cys-rich motif
BTPBromodomain transcription factors and PHD domain containing proteins
BtzCASC3/Barentsz eIF4AIII binding
c-SKI_SMAD_bindc-SKI Smad4 binding domain
C1Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
C1_4TFIIH C1-like domain
C1QComplement component C1q domain.
C2Protein kinase C conserved region 2 (CalB)
C345CNetrin C-terminal Domain
C4C-terminal tandem repeated domain in type 4 procollagens
CACadherin repeats.
Ca_chan_IQVoltage gated calcium channel IQ domain
CactinC_cactusCactus-binding C-terminus of cactin protein
CADDomains present in proteins implicated in post-mortem DNA fragmentation
CADGDystroglycan-type cadherin-like domains.
Cadherin_proCadherin prodomain like
Calx_betaDomains in Na-Ca exchangers and integrin-beta4
CaM_bindingPlant calmodulin-binding domain
CaMBDCalmodulin binding domain
CAMSAP_CKKMicrotubule-binding calmodulin-regulated spectrin-associated
Candida_ALS_NCell-wall agglutinin N-terminal ligand-sugar binding
Candidatesub-family of tyrosine recombinases
CAP10Putative lipopolysaccharide-modifying enzyme.
Carb_anhydraseEukaryotic-type carbonic anhydrase
CARDCaspase recruitment domain
CarD_TRCFCarD-like/TRCF domain
CARPDomain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product.
cas1cas1 solo endonuclease
CAScCaspase, interleukin-1 beta converting enzyme (ICE) homologues
CASH Domain present in carbohydrate binding proteins and sugar hydrolses
CATChloramphenicol acetyltransferase
CAT_RBDCAT RNA binding domain
Cation_ATPase_NCation transporter/ATPase, N-terminus
CBD_IVCellulose Binding Domain Type IV
CBFCCAAT-Binding transcription Factor
CBM49Carbohydrate binding domain CBM49
CBM_10Cellulose or protein binding domain
CBM_2Starch binding domain
CBM_25Carbohydrate binding domain
CBM_3Cellulose binding domain
CBM_XPutative carbohydrate binding domain
CBSDomain in cystathionine beta-synthase and other proteins.
CCPDomain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
CDC37_CCdc37 C terminal domain
CDC37_MCdc37 Hsp90 binding domain
CDC37_NCdc37 N terminal kinase binding
CDC48_2Cell division protein 48 (CDC48) domain 2
CDC48_NCell division protein 48 (CDC48) N-terminal domain
Cdc6_CCDC6, C terminal
CDT1DNA replication factor CDT1 like
CENPBPutative DNA-binding domain in centromere protein B, mouse jerky and transposases.
Cg6151-PUncharacterized conserved protein CG6151-P
CHCalponin homology domain
CHB_HEXPutative carbohydrate binding domain
CheWTwo component signalling adaptor domain
CHKZnF_C4 abd HLH domain containing kinases domain
CHRDA domain in the BMP inhibitor chordin and in microbial proteins.
CHROMOChromatin organization modifier domain
ChShChromo Shadow Domain
ChtBD1Chitin binding domain
ChtBD2Chitin-binding domain type 2
ChtBD3Chitin-binding domain type 3
ChWClostridial hydrophobic, with a conserved W residue, domain.
CHZHistone chaperone domain CHZ
CIMRCation-independent mannose-6-phosphate receptor repeat
Cir_NN-terminal domain of CBF1 interacting co-repressor CIR
Citrate_ly_ligCitrate lyase ligase C-terminal domain
CK_II_betaCasein kinase II regulatory subunit
CKSCyclin-dependent kinase regulatory subunit
CLaCLUSTERIN alpha chain
CLECTC-type lectin (CTL) or carbohydrate-recognition domain (CRD)
CLHClathrin heavy chain repeat homology
CLIPClip or disulphide knot domain
ClpB_D2-smallC-terminal, D2-small domain, of ClpB protein
CM_2Chorismate mutase type II
CNHDomain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
cNMPCyclic nucleotide-monophosphate binding domain
CNXConnexin homologues
CO_deh_flav_CCO dehydrogenase flavoprotein C-terminal domain
CoA_bindingCoA binding domain
CoA_transCoenzyme A transferase
CobW_C Cobalamin synthesis protein cobW C-terminal domain
Cog4COG4 transport protein
COG6Conserved oligomeric complex COG6
Col_cuticle_NNematode cuticle collagen N-terminal domain
COLFIFibrillar collagens C-terminal domain
Connexin_CCCGap junction channel protein cysteine-rich domain
CorC_HlyCTransporter associated domain
CpcDCpcD/allophycocyanin linker domain
CPDccatalytic domain of ctd-like phosphatases
Cpl-7Cpl-7 lysozyme C-terminal domain
Cpn10Chaperonin 10 Kd subunit
CPSase_L_D3Carbamoyl-phosphate synthetase large chain, oligomerisation domain
CPSase_sm_chainCarbamoyl-phosphate synthase small chain, CPSase domain
CRAL_TRIO_NCRAL/TRIO, N-terminal domain
CRFcorticotropin-releasing factor
CRM1_CCRM1 C terminal
CSF2Granulocyte-macrophage colony-simulating factor (GM-CSF)
CSPCold shock protein domain
CTC-terminal cystine knot-like domain (CTCK)
CTDSpt5 C-terminal nonapeptide repeat binding Spt4
CTLHC-terminal to LisH motif.
CTNSRepeated motif present between transmembrane helices in cystinosin, yeast ERS1p, mannose-P-dolichol utilization defect 1, and other hypothetical proteins.
CUBDomain first found in C1r, C1s, uEGF, and bone morphogenetic protein.
CUEDomain that may be involved in binding ubiquitin-conjugating enzymes (UBCs)
Cullin_Nedd8Cullin protein neddylation domain
CXCTesmin/TSO1-like CXC domain
CxxC_CXXC_SSSS Putative regulatory protein
CYCystatin-like domain
Cyansub-family of tyrosine recombinases
Cyanate_lyaseCyanate lyase C-terminal domain, Cyanate hydratase
CYCcAdenylyl- / guanylyl cyclase, catalytic domain
CYCLINdomain present in cyclins, TFIIB and Retinoblastoma
CysPcCalpain-like thiol protease family.
Cyt-b5Cytochrome b5-like Heme/Steroid binding domain
D-ser_dehydratPutative serine dehydratase domain
D5_ND5 N terminal like
DabbStress responsive A/B Barrel Domain
DAGKaDiacylglycerol kinase accessory domain (presumed)
DAGKcDiacylglycerol kinase catalytic domain (presumed)
DALR_1DALR anticodon binding domain
DAXDomain present in Dishevelled and axin
DBBDof, BCAP, and BANK (DBB) motif
DBP10CTDBP10CT (NUC160) domain
DBR1Lariat debranching enzyme, C-terminal domain
DCP2Dcp2, box A domain
DCXDomain in the Doublecortin (DCX) gene product
DDEfamily of Ribonuclease H like domains involved in transposition
DDE_1DDE transposase sub-family
DDE_2DDE Mu phage transposase sub-family
DDE_3DDE transposase sub-family
DDE_5DDE transposase sub-family
DDE_Tnp_1DDE transposase sub-family
DDE_Tnp_1_2DDE transposase sub-family
DDE_Tnp_1_3DDE transposase sub-family
DDE_Tnp_1_4DDE transposase sub-family
DDE_Tnp_1_5DDE transposase sub-family
DDE_Tnp_1_6DDE transposase sub-family
DDE_Tnp_1_7DDE transposase sub-family
DDE_Tnp_2DDE transposase sub-family
DDE_Tnp_4DDE transposase sub-family
DDE_Tnp_IS1DDE transposase sub-family
DDE_Tnp_IS1595DDE transposase sub-family
DDE_Tnp_IS240DDE transposase sub-family
DDE_Tnp_IS66DDE transposase sub-family
DDE_Tnp_ISAZ013DDE transposase sub-family
DDE_Tnp_ISL3DDE transposase sub-family
DDE_Tnp_Tn3DDE transposase sub-family
dDENNDomain always found downstream of DENN domain, found in a variety of signalling proteins
DDTdomain in different transcription and chromosome remodeling factors
DEATHDEATH domain, found in proteins involved in cell death (apoptosis).
DEDDeath effector domain
DEDDDEDD transposase
DEDD_Tnp_IS110DEDD transposase family
Defensin_propepDefensin propeptide
DEFSNDefensin/corticostatin family
DELLATranscriptional regulator DELLA protein N terminal
DENNDomain found in a variety of signalling proteins, always encircled by uDENN and dDENN
DeoCDeoC/LacD family aldolase
DeoRCDeoR C terminal sensor domain
DEPDomain found in Dishevelled, Egl-10, and Pleckstrin
DEXDcDEAD-like helicases superfamily
DHDPSDihydrodipicolinate synthetase family
DIM1Mitosis protein DIM1
DISINHomologues of snake disintegrins
DKCLDDKCLD (NUC011) domain
DMDoublesex DNA-binding motif
DM10Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases.
DM11Domains in hypothetical proteins in Drosophila including 2 in CG15241 and CG9329.
DM13Domain present in fly proteins (CG14681, CG12492, CG6217), worm H06A10.1 and Arabidopsis thaliana MBG8.9.
DM14Repeats in fly CG4713, worm Y37H9A.3 and human FLJ20241.
DM15Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function.
DM16Repeats in sea squirt COS41.4, worm R01H10.6, fly CG1126 etc.
DM3Zinc finger domain in CG10631, C. elegans LIN-15B and human P52rIPK.
DM4_12DM4/DM12 family of domains in Drosophila melanogaster proteins of unknown function.
DM5Domain of unknown function, currently peculiar to Drosophila.
DM6Cysteine-rich domain currently specific to Drosophila.
DM7Domain of unknown function in Drosophila CG15332, CG15333 and CG18293
DM8Repeats found in several Drosophila proteins.
DM9Repeats found in Drosophila proteins.
DMAP_bindingDMAP1-binding Domain
DNA_mis_repairDNA mismatch repair protein, C-terminal domain
DnaG_DnaB_bindDNA primase DnaG DnaB-binding
DnaJDnaJ molecular chaperone homology domain
DNaseIcdeoxyribonuclease I
DoHPossible catecholamine-binding domain present in a variety of eukaryotic proteins.
DPTranscription factor DP
DPBB_1Rare lipoprotein A (RlpA)-like double-psi beta-barrel
Drf_FH3Diaphanous FH3 Domain
Drf_GBDDiaphanous GTPase-binding Domain
DRY_EERYAlternative splicing regulator
DSLdelta serrate ligand
DSPcDual specificity phosphatase, catalytic domain
DSRMDouble-stranded RNA binding motif
DSX_dimerDoublesex dimerisation domain
DUF1041Domain of Unknown Function (DUF1041)
DUF106Integral membrane protein DUF106
DUF1086Domain of Unknown Function (DUF1086)
DUF1220Repeat of unknown function (DUF1220)
DUF1693Domain of unknown function (DUF1693)
DUF1713Mitochondrial domain of unknown function (DUF1713)
DUF1716Eukaryotic domain of unknown function (DUF1716)
DUF1751Eukaryotic integral membrane protein (DUF1751)
DUF3385Domain of unknown function
DUF3402Domain of unknown function (DUF3402)
DUF3452Domain of unknown function (DUF3452)
DUF3454Domain of unknown function
DUF3480Domain of unknown function (DUF3480)
DUF3635Domain of unknown function
DUF663Protein of unknown function (DUF663)
DUF862PPPDE putative peptidase domain
DUSPDomain in ubiquitin-specific proteases.
DWADomain A in dwarfin family proteins
DWBDomain B in dwarfin family proteins
DYNcDynamin, GTPase
Dynein_lightDynein light chain type 1
DysFCDysferlin domain, C-terminal region.
DysFNDysferlin domain, N-terminal region.
DZFdomain in DSRM or ZnF_C2H2 domain containing proteins
E2F_TDPE2F/DP family winged-helix DNA-binding domain
EALPutative diguanylate phosphodiesterase
EB_dhEthylbenzene dehydrogenase
ECSIT_CtermC-terminal domain of the ECSIT protein
EF-1_beta_acidEukaryotic elongation factor 1 beta central acidic region
EF1_GNEEF-1 guanine nucleotide exchange domain
EF1GElongation factor 1 gamma, conserved domain
EFG_CElongation factor G C-terminus
EFG_IVElongation factor G, domain IV
EFhEF-hand, calcium binding motif
efhand_Ca_insenCa2+ insensitive EF hand
EFPElongation factor P (EF-P) OB domain
EGFEpidermal growth factor-like domain.
EGF_CACalcium-binding EGF-like domain
EGF_LamLaminin-type epidermal growth factor-like domai
EGF_likeEGF domain, unclasssified subfamily
EHEps15 homology domain
eIF-5aEukaryotic elongation factor 5A hypusine, DNA-binding OB fold
eIF1aeukaryotic translation initiation factor 1A
eIF2B_5domain present in translation initiation factor eIF2B and eIF5
eIF3_NeIF3 subunit 6 N terminal domain
eIF5CDomain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5
eIF6translation initiation factor 6
EKRDomain of unknown function
ELFV_dehydrogGlutamate/Leucine/Phenylalanine/Valine dehydrogenase
Elong-fact-P_CElongation factor P, C-terminal
Elp3Elongator protein 3, MiaB family, Radical SAM
EMP24_GP25Lemp24/gp25L/p24 family/GOLD
ENDO3cendonuclease III
Endonuclease_NSDNA/RNA non-specific endonuclease
Enolase_CEnolase, C-terminal TIM barrel domain
Enolase_NEnolase, N-terminal domain
ENTHEpsin N-terminal homology (ENTH) domain
EPH_lbdEphrin receptor ligand binding domain
Ephrin_rec_likePutative ephrin-receptor like
ERCC4ERCC4 domain
EsV_1_7EsV-1-7 repeat
ETFElectron transfer flavoprotein domain
ETSerythroblast transformation specific domain
ExcaliburExcalibur calcium-binding domain
EZ_HEATE-Z type HEAT repeats
FAFERM adjacent (FA)
FA58CCoagulation factor 5/8 C-terminal domain, discoidin domain
FABDF-actin binding domain (FABD)
FACT-Spt16_NlobFACT complex subunit SPT16 N-terminal lobe domain
FANCL_CFANCL C-terminal domain
Fapy_DNA_glycoFormamidopyrimidine-DNA glycosylase N-terminal domain
FAS1Four repeated domains in the Fasciclin I family of proteins, present in many other contexts.
FBAF-box associated region
FBDdomain in FBox and BRCT domain containing plant proteins
FBGFibrinogen-related domains (FReDs)
FBOXA Receptor for Ubiquitination Targets
fCBDFungal-type cellulose-binding domain
FCHFes/CIP4 homology domain
FDX-ACBFerredoxin-fold anticodon binding domain
Fe_hyd_SSUIron hydrogenase small subunit
FERM_CFERM C-terminal PH-like domain
FFContains two conserved F residues
FGFAcidic and basic fibroblast growth factor family.
FH2Formin Homology 2 Domain
FHAForkhead associated domain
Fib_alphaFibrinogen alpha/beta chain family
FilamentIntermediate filament protein
FIMACfactor I membrane attack complex
FISNAFish-specific NACHT associated domain
FKS1_dom11,3-beta-glucan synthase subunit FKS1
Flavin_ReductFlavin reductase like domain
FlavokinaseRiboflavin kinase
Flu_M1_CInfluenza Matrix protein (M1) C-terminal domain
Fmp27_GFWDKRNA pol II promoter Fmp27 protein domain
Fmp27_SWRNA pol II promoter Fmp27 protein domain
Fmp27_WPPWRNA pol II promoter Fmp27 protein domain Provide feedback
FN1Fibronectin type 1 domain
FN2Fibronectin type 2 domain
FN3Fibronectin type 3 domain
Fn3_likeFibronectin type III-like domain
FolBDihydroneopterin aldolase
FOLNFollistatin-N-terminal domain-like
FoP_duplicationC-terminal duplication domain of Friend of PRMT1
Frataxin_CyayFrataxin-like domain
FrizzledFrizzled/Smoothened family membrane region
FSA_CFragile site-associated protein C-terminus
FTCDFormiminotransferase domain
FTCD_NFormiminotransferase domain, N-terminal subdomain
FTO_NTDFTO catalytic domain
FTPeel-Fucolectin Tachylectin-4 Pentaxrin-1 Domain
FtsACell division protein FtsA
FUFurin-like repeats
Fungal_transFungal specific transcription factor domain
FYRC"FY-rich" domain, C-terminal region
FYRN"FY-rich" domain, N-terminal region
FYVEProtein present in Fab1, YOTB, Vac1, and EEA1
G2FG2 nidogen domain and fibulin
G3P_acyltransfGlycerol-3-phosphate acyltransferase
G_alphaG protein alpha subunit
G_gammaGGL domain
G_patchglycine rich nucleic binding domain
GAGA module
GAFDomain present in phytochromes and cGMP-specific phosphodiesterases.
GAGA_bindGAGA binding protein-like family
Gal-bind_lectinGalactoside-binding lectin
GAL4GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain
GARS_APhosphoribosylglycinamide synthetase, ATP-grasp (A) domain
GARS_CPhosphoribosylglycinamide synthetase, C domain
GAS2Growth-Arrest-Specific Protein 2 Domain
GASTRINgastrin / cholecystokinin / caerulein family
GATase_5CobB/CobQ-like glutamine amidotransferase domain
GatB_YqeyGatB domain
GEDDynamin GTPase effector domain
GELGelsolin homology domain
Gemini_AL1HUH phage replication sub-family
GermaneSporulation and spore germination
GGDEFdiguanylate cyclase
GGLG protein gamma subunit-like motifs
GHAGlycoprotein hormone alpha chain homologues.
GHBGlycoprotein hormone beta chain homologues.
GIDA_assoc_3GidA associated domain 3
GITHelical motif in the GIT family of ADP-ribosylation factor GTPase-activating proteins
GIYcGIY-YIG type nucleases (URI domain)
GLADomain containing Gla (gamma-carboxyglutamate) residues.
Gln-synt_CGlutamine synthetase, catalytic domain
GLUCAGlucagon like hormones
Glyco_10Glycosyl hydrolase family 10
Glyco_25Glycosyl hydrolases family 25
Glyco_32Glycosyl hydrolases family 32
GoLocoLGN motif, putative GEFs specific for G-alpha GTPases
Gp_dh_NGlyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
GPSG-protein-coupled receptor proteolytic site domain
GRAMdomain in glucosyltransferases, myotubularins and other putative membrane-associated proteins
Gripgolgin-97, RanBP2alpha,Imh1p and p230/golgin-245
GSGS motif
GuKcGuanylate kinase homologues.
GYFContains conserved Gly-Tyr-Phe residues
GYRMotif of unknown function with conserved Gly, Tyr, Arg tripeptide in Drosophila proteins.
H-kinase_dimSignal transducing histidine kinase, homodimeric domain
H15Domain in histone families 1 and 5
H2AHistone 2A
H2BHistone H2B
H2THFormamidopyrimidine-DNA glycosylase H2TH domain
H3Histone H3
H4Histone H4
HA2Helicase associated domain (HA2) Add an annotation
HABP4_PAI-RBP1Hyaluronan / mRNA binding family
Haem_bdHaem-binding domain
Haem_oxygenase_2Iron-containing redox enzyme
Haemagg_acthaemagglutination activity domain
HALZhomeobox associated leucin zipper
HAMPHAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain
HAP1_NHAP1 N-terminal conserved region
HATHAT (Half-A-TPR) repeats
HATPase_cHistidine kinase-like ATPases
HBMhelical bimodular (HBM) domain
HDAC_interactHistone deacetylase (HDAC) interacting
HDcMetal dependent phosphohydrolases with conserved 'HD' motif.
HECTcDomain Homologous to E6-AP Carboxyl Terminus with
HELICchelicase superfamily c-terminal domain
HEPNHigher Eukarytoes and Prokaryotes Nucleotide-binding domain
HhH1Helix-hairpin-helix DNA-binding motif class 1
HhH2Helix-hairpin-helix class 2 (Pol1 family) motifs
HintCHint (Hedgehog/Intein) domain C-terminal region
HintNHint (Hedgehog/Intein) domain N-terminal region
HisKAHis Kinase A (phosphoacceptor) domain
HLHhelix loop helix domain
HMGhigh mobility group
HMG17domain in high mobilty group proteins HMG14 and HMG 17
HNHcHNH nucleases
HNSDomain in histone-like proteins of HNS family
HOLILigand binding domain of hormone receptors
HormRDomain present in hormone receptors
HPTHistidine Phosphotransfer domain
Hr1Rho effector or protein kinase C-related kinase homology region 1 homologues
HRDCHelicase and RNase D C-terminal
HSAdomain in helicases and associated with SANT domains
HSFheat shock factor
HTH_ARAChelix_turn_helix, arabinose operon control protein
HTH_ARSRhelix_turn_helix, Arsenical Resistance Operon Repressor
HTH_ASNChelix_turn_helix ASNC type
HTH_CRPhelix_turn_helix, cAMP Regulatory protein
HTH_DEORhelix_turn_helix, Deoxyribose operon repressor
HTH_DTXRHelix-turn-helix diphteria tox regulatory element
HTH_GNTRhelix_turn_helix gluconate operon transcriptional repressor
HTH_ICLRhelix_turn_helix isocitrate lyase regulation
HTH_LACIhelix_turn _helix lactose operon repressor
HTH_LUXRhelix_turn_helix, Lux Regulon
HTH_MARRhelix_turn_helix multiple antibiotic resistance protein
HTH_MERRhelix_turn_helix, mercury resistance
HTH_XREHelix-turn-helix XRE-family like proteins
HTTMHorizontally Transferred TransMembrane Domain
HUHvirus and plasmid replication protein with conserved HXH motif
huh_y1HUH transposase Y1 type
huh_y2HUH transposase Y2 type
HWE_HKHWE histidine kinase
HXHemopexin-like repeats.
IBInsulin growth factor-binding protein homologues
IBN_NImportin-beta N-terminal domain
IBRIn Between Ring fingers
ICA69Islet cell autoantigen ICA69, C-terminal domain
IENR1Intron encoded nuclease repeat motif
IENR2Intron-encoded nuclease repeat 2
IFabdInterferon alpha, beta and delta.
IG_FLMNFilamin-type immunoglobulin domains
IG_likeImmunoglobulin like
IGc1Immunoglobulin C-Type
IGc2Immunoglobulin C-2 Type
IGvImmunoglobulin V-Type
IKKbetaNEMObindI-kappa-kinase-beta NEMO binding domain
IL1Interleukin-1 homologues
IL10Interleukin-10 family
IL2Interleukin-2 family
IL4_13Interleukins 4 and 13
IL6Interleukin-6 homologues
IL7Interleukin-7 and interleukin-9 family.
IlGFInsulin / insulin-like growth factor / relaxin family.
IMPDHIMP dehydrogenase / GMP reductase domain
INBIntegrin beta subunits (N-terminal portion of extracellular region)
INGInhibitor of growth proteins N-terminal histone-binding
Inhibitor_I29Cathepsin propeptide inhibitor domain (I29)
Int_alphaIntegrin alpha (beta-propellor repeats).
Int_BPP-1sub-family of tyrosine recombinases
Int_Brujitasub-family of tyrosine recombinases
Int_CTnDOTsub-family of tyrosine recombinases
Int_Dessub-family of tyrosine recombinases
Int_P2sub-family of tyrosine recombinases
Int_SXTsub-family of tyrosine recombinases
Int_Tn916sub-family of tyrosine recombinases
Integronsub-family of tyrosine recombinases
IntKXsub-family of tyrosine recombinases
IPPcInositol polyphosphate phosphatase, catalytic domain homologues
IPTig-like, plexins, transcription factors
IQShort calmodulin-binding motif containing conserved Ile and Gln residues.
IRFinterferon regulatory factor
IRF-3Interferon-regulatory factor 3
IROMotif in Iroquois-class homeodomain proteins (only). Unknown function.
IRSPhosphotyrosine-binding domain
Iso_dhIsocitrate/isopropylmalate dehydrogenase
ITAMImmunoreceptor tyrosine-based activation motif
JacalinJacalin-like lectin domain
JHBPJuvenile hormone binding protein domains in insects.
JmjCA domain family that is part of the cupin metalloenzyme superfamily.
JmjNSmall domain found in the jumonji family of transcription factors
K167RK167/Chmadrin repeat
KAPKinesin-associated protein (KAP)
KASHNuclear envelope localisation domain
KAT11Histone acetylation protein
KAZALKazal type serine protease inhibitors
KbaAKinB-signalling pathway activation in sporulation
KHK homology RNA-binding domain
Kin17_midDomain of Kin17 curved DNA-binding protein
KINDkinase non-catalytic C-lobe domain
KIScKinesin motor, catalytic domain. ATPase.
KLRAQPredicted coiled-coil domain-containing protein
KOWKOW (Kyprides, Ouzounis, Woese) motif.
KRKringle domain
KRABkrueppel associated box
KRAP_IP3R_bindKi-ras-induced actin-interacting protein-IP3R-interacting domain
KRBA1KRBA1 family repeat
KUBPTI/Kunitz family of serine protease inhibitors.
Ku78Ku70 and Ku80 are 70kDa and 80kDa subunits of the Lupus Ku autoantigen
L27domain in receptor targeting proteins Lin-2 and Lin-7
L51_S25_CI-B8Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain
LADomain in the RNA-binding Lupus La protein; unknown function
LAB_NLipid A Biosynthesis N-terminal domain
Lactamase_BMetallo-beta-lactamase superfamily
LAG1_DNAbindLAG1, DNA binding
LamBLaminin B domain
LamGLaminin G domain
LamGLLamG-like jellyroll fold domain
LamNTLaminin N-terminal domain (domain VI)
LAMTORLate endosomal/lysosomal adaptor and MAPK and MTOR activator
LANC_likeLanthionine synthetase C-like protein
LDLaLow-density lipoprotein receptor domain class A
LEMin nuclear membrane-associated proteins
LeuA_dimerLeuA allosteric (dimerisation) domain
Leuk-A4-hydro_CLeukotriene A4 hydrolase, C-terminal
LH2Lipoxygenase homology 2 (beta barrel) domain
LIF_OSMleukemia inhibitory factor
Lig_chan-Glu_bdLigated ion channel L-glutamate- and glycine-binding site
LIGANcLigase N family
LIMZinc-binding domain present in Lin-11, Isl-1, Mec-3.
LINKLink (Hyaluronan-binding)
Lipid_DESSphingolipid Delta4-desaturase (DES)
LisHLissencephaly type-1-like homology motif
LITAFPossible membrane-associated motif in LPS-induced tumor necrosis factor alpha factor (LITAF), also known as PIG7, and other animal proteins.
LMWPcLow molecular weight phosphatase family
LONFound in ATP-dependent protease La (LON)
LonginRegulated-SNARE-like domain
LPD_NLipoprotein N-terminal Domain
LRRLeucine-rich repeats, outliers
LRR_BACLeucine-rich repeats, bacterial type
LRR_CCLeucine-rich repeat - CC (cysteine-containing) subfamily
LRR_RILeucine rich repeat, ribonuclease inhibitor type
LRR_SD22Leucine-rich repeat, SDS22-like subfamily
LRR_TYPLeucine-rich repeats, typical (most populated) subfamily
LRRcapoccurring C-terminal to leucine-rich repeats
LRRCTLeucine rich repeat C-terminal domain
LRRNTLeucine rich repeat N-terminal domain
LSM14Scd6-like Sm domain
LULy-6 antigen / uPA receptor -like domain
LYLow-density lipoprotein-receptor YWTD domain
LysMLysin motif
LytTRLytTr DNA-binding domain
LYZ1 Alpha-lactalbumin / lysozyme C
LYZ2Lysozyme subfamily 2
M16C_associatedPeptidase M16C associated
M60-likePeptidase M60-like family
MAMethyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).
MA3Domain in DAP-5, eIF4G, MA-3 and other proteins.
MacMaltose acetyltransferase
MACPFmembrane-attack complex / perforin
Mad3_BUB1_IMad3/BUB1 hoMad3/BUB1 homology region 1
MAGEMelanoma-associated antigen
MAGE_NMelanoma associated antigen family N terminal
Mago-bindMago binding
MAGUK_N_PESTPolyubiquitination (PEST) N-terminal domain of MAGUK
malicMalic enzyme, N-terminal domain
Malic_MMalic enzyme, NAD binding domain
MAMDomain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
MamL-1MamL-1 domain
MAPKK1_IntMitogen-activated protein kinase kinase 1 interacting
MATHmeprin and TRAF homology
Matrilin_ccoilTrimeric coiled-coil oligomerisation domain of matrilin
MBDMethyl-CpG binding domain
MBTPresent in Drosophila Scm, l(3)mbt, and vertebrate SCML2
MbtHMbtH-like protein
MCMminichromosome maintenance proteins
Mcm10Mcm10 replication factor
Med12Transcription mediator complex subunit Med12
MeTrcMethyltransferase, chemotaxis proteins
MGSMGS-like domain
MgtE_NMgtE intracellular N domain
MHC_II_alphaClass II histocompatibility antigen, alpha domain
MHC_II_betaClass II histocompatibility antigen, beta domain
MIF4GMiddle domain of eukaryotic initiation factor 4G (eIF4G)
MiltonKinesin associated protein
MIRDomain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
MITMicrotubule Interacting and Trafficking molecule domain
MLDomain involved in innate immunity and lipid metabolism.
MltAMltA specific insert domain
Mob1_phoceinMob1/phocein family
Mob_PreHUH conjugative element mobility domain
MobA_MobLHUH conjugative element mobility domain
MoCF_biosynthProbable molybdopterin binding domain
Molybdop_Fe4S4Molybdopterin oxidoreductase Fe4S4 domain
MORNPossible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases.
MR_MLEMandelate racemase / muconate lactonizing enzyme, C-terminal domain
Mre11_DNA_bindMre11 DNA-binding presumed domain
MterfMitochondrial termination factor repeats
MutHDNA mismatch repair enzyme MutH
MutL_CMutL C terminal dimerisation domain
MUTSacATPase domain of DNA mismatch repair MUTS family
MUTSdDNA-binding domain of DNA mismatch repair MUTS family
Mycsub-family of tyrosine recombinases
MYScMyosin. Large ATPases.
MyTH4Domain in Myosin and Kinesin Tails
N-glycanase_NPeptide-N-glycosidase F, N terminal
N-SETCOMPASS (Complex proteins associated with Set1p) component N
N1221N1221-like protein
NADH-G_4Fe-4S_3NADH-ubiquinone oxidoreductase-G iron-sulfur binding region
NADH_4Fe-4SNADH-ubiquinone oxidoreductase-F iron-sulfur binding region
NAT_PEPNatriuretic peptide
Nbs1_CDNA damage repair protein Nbs1
NEATNEAr Transporter domain
Nfu_NScaffold protein Nfu/NifU N terminal
NGFNerve growth factor (NGF or beta-NGF)
NGNIn Spt5p, this domain may confer affinity for Spt4p. It possesses a RNP-like fold.
NHNeurohypophysial hormones
NIDOExtracellular domain of unknown function in nidogen (entactin) and hypothetical proteins.
NLDomain found in Notch and Lin-12
NMUNeuromedin U
NOSICNOSIC (NUC001) domain
NPPPro-opiomelanocortin, N-terminal region
NRFN-terminal domain in C. elegans NRF-6 (Nose Resistant to Fluoxetine-4) and NDG-4 (resistant to nordihydroguaiaretic acid-4).
NTRTissue inhibitor of metalloproteinase family.
NUCDNA/RNA non-specific endonuclease
OLFOlfactomedin-like domains
OMPdecaseOrotidine 5'-phosphate decarboxylase / HUMPS family
OmpHOuter membrane protein (OmpH-like)
Op_neuropeptideOpioids neuropeptide
ORANGEOrange domain
OrfB_IS605DDE transposase sub-family
P-IINitrogen regulatory protein P-II
P4HcProlyl 4-hydroxylase alpha subunit homologues.
P68HRP68HR (NUC004) repeat
PA2cPhospholipase A2
PACMotif C-terminal to PAS motifs (likely to contribute to PAS structural domain)
PAHPancreatic hormones / neuropeptide F / peptide YY family
PAMPCI/PINT associated module
PAN_APdivergent subfamily of APPLE domains
ParBParB-like nuclease domain
PASPAS domain
PAWdomain present in PNGases and other hypothetical proteins
PAXPaired Box domain
PB1PB1 domain
PBDP21-Rho-binding domain
PbH1Parallel beta-helix repeats
PBP5_CPenicillin-binding protein 5, C-terminal domain
PBPbBacterial periplasmic substrate-binding proteins
PBPeEukaryotic homologues of bacterial periplasmic substrate binding proteins.
PDP or trefoil or TFF domain
PDDEXKPD-(D/E)XK nuclease transposase
PDDEXK_2PD-(D/E)XK nuclease transposase sub-family
PDGFPlatelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
PDZDomain present in PSD-95, Dlg, and ZO-1/2.
Pept_C1Papain family cysteine protease
PepX_CX-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PepX_NX-Prolyl dipeptidyl aminopeptidase PepX, N-terminal
PGA_capBacterial capsule synthesis protein PGA_cap
PGAMPhosphoglycerate mutase family
PGRPAnimal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme.
PHPleckstrin homology domain.
Phage_GPAHUH phage replication sub-family
Phage_integrasePfam phage integrase family
PHBprohibitin homologues
PhBPInsect pheromone/odorant binding protein domains.
PHDPHD zinc finger
PhnA_Zn_RibbonPhnA Zinc-Ribbon
PI3K_C2Phosphoinositide 3-kinase, region postulated to contain C2 domain
PI3K_p85BPI3-kinase family, p85-binding domain
PI3K_rbdPI3-kinase family, Ras-binding domain
PI3KaPhosphoinositide 3-kinase family, accessory domain (PIK domain)
PI3KcPhosphoinositide 3-kinase, catalytic domain
PINcLarge family of predicted nucleotide-binding domains
PINTmotif in proteasome subunits, Int-6, Nip-1 and TRIP-15
PIP49_NN-term cysteine-rich ER, FAM69
PIPKcPhosphatidylinositol phosphate kinases
PKDRepeats in polycystic kidney disease 1 (PKD1) and other proteins
PKS_ATAcyl transferase domain in polyketide synthase (PKS) enzymes.
PKS_KSBeta-ketoacyl synthase
PKS_MTMethyltransferase in polyketide synthase (PKS) enzymes.
PKS_PPPhosphopantetheine attachment site
PLAcCytoplasmic phospholipase A2, catalytic subunit
PLCXcPhospholipase C, catalytic domain (part); domain X
PLCYcPhospholipase C, catalytic domain (part); domain Y
PLDcPhospholipase D. Active site motifs.
PLECPlectin repeat
PLPMyelin proteolipid protein (PLP or lipophilin)
PlsCPhosphate acyltransferases
Plus3Short conserved domain in transcriptional regulators.
PMEIPlant invertase/pectin methylesterase inhibitor
POL3BcDNA polymerase III beta subunit
POLAcDNA polymerase A domain
POLBcDNA polymerase type-B family
POLIIIAcDNA polymerase alpha chain like domain
POLXcDNA polymerase X family
PolyAC-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein.
POP4A domain found in a protein subunit of human RNase MRP and RNase P ribonucleoprotein complexes and archaeal proteins.
PostSETCysteine-rich motif following a subset of SET domains
POUFound in Pit-Oct-Unc transcription factors
POXdomain associated with HOX domains
PP2AcProtein phosphatase 2A homologues, catalytic domain.
PP2C_SIGSigma factor PP2C-like phosphatases
PP2CcSerine/threonine phosphatases, family 2C, catalytic domain
PQQbeta-propeller repeat
PreSETN-terminal to some SET domains
Pribosyltran_NN-terminal domain of ribose phosphate pyrophosphokinase
PriCT_1Primase C terminal 1 (PriCT-1)
Prim-PolBifunctional DNA primase/polymerase, N-terminal
Prim_Zn_RibbonZinc-binding domain of primase-helicase
Pro-kuma_activPro-kumamolisin, activation domain
Pro_CACarbonic anhydrase
ProQProQ/FINO family
ProRS-C_1Prolyl-tRNA synthetase, C-terminal
Proteasome_A_NProteasome subunit A N-terminal signature Add an annotation
PRPMajor prion protein
PSAParamecium Surface Antigen Repeat
PSIdomain found in Plexins, Semaphorins and Integrins
PSNPresenilin, signal peptide peptidase, family
PSPproline-rich domain in spliceosome associated proteins
PTBPhosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain
PTBIPhosphotyrosine-binding domain (IRS1-like)
PTEN_C2C2 domain of PTEN tumour-suppressor protein
PTHParathyroid hormone
PTIPlant trypsin inhibitors
PTNPleiotrophin / midkine family
PTPcProtein tyrosine phosphatase, catalytic domain
PTPc_DSPcProtein tyrosine phosphatase, catalytic domain, undefined specificity
PTPc_motifProtein tyrosine phosphatase, catalytic domain motif
PTPlike_phytaseInositol hexakisphosphate
PTXPentraxin / C-reactive protein / pentaxin family
PUAPutative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase
PUGdomain in protein kinases, N-glycanases and other nuclear proteins
PumilioPumilio-like repeats
PURDNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes and the Bacteroides-Cytophaga-Flexibacter bacteria.
PWIPWI, domain in splicing factors
PWWPdomain with conserved PWWP motif
PXPhoX homologous domain, present in p47phox and p40phox.
PXADomain associated with PX domains
PYNP_CPyrimidine nucleoside phosphorylase C-terminal domain
R3HPutative single-stranded nucleic acids-binding domain
RARas association (RalGDS/AF-6) domain
RABRab subfamily of small GTPases
rADcRibosomal RNA adenine dimethylases
RANRan (Ras-related nuclear proteins) /TC4 subfamily of small GTPases
RanBDRan-binding domain
Rapamycin_bindRapamycin binding domain
Raptor_NRaptor N-terminal CASPase like domain
RASRas subfamily of RAS small GTPases
Ras_bdg_2Ras-binding domain of Byr2
RasGAPGTPase-activator protein for Ras-like GTPases
RasGEFGuanine nucleotide exchange factor for Ras-like small GTPases
RasGEF_N_2Rapamycin-insensitive companion of mTOR RasGEF_N domain
RasGEFNGuanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
RB_ARetinoblastoma-associated protein A domain
Rb_CRb C-terminal domain
RBDRaf-like Ras-binding domain
RECcheY-homologous receiver domain
RelA_SpoTRegion found in RelA / SpoT proteins
RelaxaseHUH conjugative element mobility domain
Rep_1HUH conjugative element mobility domain
Rep_2HUH conjugative element mobility domain
Rep_NHUH phage replication sub-family
Resolvase Resolvase, N terminal domain
RFX5_DNA_bdgRFX5 DNA-binding domain
RGSRegulator of G protein signalling domain
RHORho (Ras homology) subfamily of Ras-like small GTPases
Rho_NRho termination factor, N-terminal domain
RHODRhodanese Homology Domain
RhoGAPGTPase-activator protein for Rho-like GTPases
RhoGEFGuanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
RIBOcRibonuclease III family
Ribosomal_L14Ribosomal protein L14p/L23e
Ribosomal_L2Ribosomal Proteins L2, RNA binding domain
Ribosomal_L2_CRibosomal Proteins L2, C-terminal domain
Ribosomal_S10Ribosomal protein S10p/S20e
Ribosomal_S13_NRibosomal S13/S15 N-terminal domain
Ribosomal_S27Ribosomal protein S27a
Ribosomal_S3AeRibosomal S3Ae family
Ribosomal_S4Ribosomal protein S4/S9 N-terminal domain
Ribosomal_S6eRibosomal protein S6e
RICINRicin-type beta-trefoil
RICTOR_MRapamycin-insensitive companion of mTOR, middle domain
RICTOR_NRapamycin-insensitive companion of mTOR, N-term
RICTOR_phosphoRapamycin-insensitive companion of mTOR, phosphorylation-site
RICTOR_VRapamycin-insensitive companion of mTOR, domain 5
RIIaRIIalpha, Regulatory subunit portion of type II PKA R-subunit
RINGRing finger
RINGvThe RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins. Some of these proteins have been shown both in vivo and in vitro to have ubiquitin E3 ligase activity.
RIORIO-like kinase
RitAsub-family of tyrosine recombinases
RitBsub-family of tyrosine recombinases
RitCsub-family of tyrosine recombinases
RL11Ribosomal protein L11/L12
RNA_pol_Rpb6RNA polymerase Rpb6
RNAse_PcPancreatic ribonuclease
Robl_LC7Roadblock/LC7 domain
Romo1Reactive mitochondrial oxygen species modulator 1
RPELRepeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
RPOL4cDNA-directed RNA-polymerase II subunit
RPOL8cRNA polymerase subunit 8
RPOL9RNA polymerase subunit 9
RPOL_NDNA-directed RNA polymerase N-terminal
RPOLA_NRNA polymerase I subunit A N-terminus
RPOLCXRNA polymerase subunit CX
RPOLDRNA polymerases D
RRMRNA recognition motif
RRM_1RNA recognition motif
RRM_2RNA recognition motif
RTC4RTC4-like domain
Rtt106Histone chaperone Rttp106-like
RuBisCO_smallRibulose bisphosphate carboxylase, small chain
rveDDE transposase retroviral integrase sub-family
rve_2DDE transposase retroviral integrase sub-family
rve_3DDE transposase retroviral integrase sub-family
S1Ribosomal protein S1-like RNA-binding domain
S4S4 RNA-binding domain
s48_45Sexual stage antigen s48/45 domain
S_100S-100/ICaBP type calcium binding domain
S_TK_XExtension to Ser/Thr-type protein kinases
S_TKcSerine/Threonine protein kinases, catalytic domain
SAASerum amyloid A proteins
SAMSterile alpha motif.
SAM_HD_adjacentSAM homeodomain adjacent domain
SAM_PNTSAM / Pointed domain
SANTSANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
SAPPutative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
SAPASaposin/surfactant protein-B A-type DOMAIN
SapBSaposin (B) Domains
SARSar1p-like members of the Ras-family of small GTPases
SARASmad anchor for receptor activation (SARA)
SATase_NSerine acetyltransferase, N-terminal
SCANleucine rich region
SCPSCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains.
SCPUSpore Coat Protein U domain
SCYIntercrine alpha family (small cytokine C-X-C) (chemokine CXC).
SEADomain found in sea urchin sperm protein, enterokinase, agrin
SEC14Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
Sec3-PIP2_bindExocyst complex component SEC3 N-terminal PIP2 binding PH
Sec63Sec63 Brl domain
Sec7Sec7 domain
SecA_DEADSecA DEAD-like domain
SecA_PP_bindSecA preprotein cross-linking domain
SEL1Sel1-like repeats.
Semasemaphorin domain
Semialdhyde_dhSemialdehyde dehydrogenase, NAD binding domain
SEPDomain present in Saccharomyces cerevisiae Shp1, Drosophila melanogaster eyes closed gene (eyc), and vertebrate p47.
SERresolvase domain containing family involved in site-specific recombination
ser_ceserine recombinase conjugative transposon sub-family
ser_lsrlarge serine recombinase sub-family
ser_tnserine transposase sub-family
SERPINSERine Proteinase INhibitors
SETSET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
SF_PPulmonary surfactant proteins
SFMSplicing Factor Motif, present in Prp18 and Pr04
SH2Src homology 2 domains
SH3Src homology 3 domains
SH3bBacterial SH3 domain homologues
ShKTShK toxin domain
SHR3_chaperoneER membrane protein SH3
Skp1Found in Skp1 protein family
SmsnRNP Sm proteins
small_GTPaseSmall GTPase of the Ras superfamily; ill-defined subfamily
SMC_hingeSMC proteins Flexible Hinge Domain
SMI1_KNR4SMI1 / KNR4 family
SMRSmall MutS-related domain
SnACSnf2-ATP coupling, chromatin remodelling complex
SNcStaphylococcal nuclease homologues
SOSomatomedin B -like domains
SOCSsuppressors of cytokine signalling
Solute_trans_aOrganic solute transporter Ostalpha
SorbSorbin homologous domain
Spc7Spc7 kinetochore protein
Spc7_NN-terminus of kinetochore NMS complex subunit Spc7
SPECSpectrin repeats
Spo7_2_NSporulation protein family 7
SPOB_abSporulation initiation phospho-transferase B, C-terminal
SpoU_sub_bindRNA 2'-O ribose methyltransferase substrate binding
SpoVT_AbrBSpoVT / AbrB like domain
SprTSprT homologues.
SPRYDomain in SPla and the RYanodine Receptor.
SPT16FACT complex subunit (SPT16/CDC68)
SPT2SPT2 chromatin protein
Spt4Spt4/RpoE2 zinc finger
SRScavenger receptor Cys-rich
SRASET and RING finger associated domain. Domain of unknown function in SET domain containing proteins and in Deinococcus radiodurans DRA1533.
SRP54SRP54-type protein, GTPase domain
SRP54_NSRP54-type protein, helical bundle domain
STARTin StAR and phosphatidylcholine transfer protein
STAT_intSTAT protein, protein interaction domain
STESTE like transcription factors
STISoybean trypsin inhibitor (Kunitz) family of protease inhibitors
STI1Heat shock chaperonin-binding motif.
STNSecretin and TonB N terminus short domain
STYKcProtein kinase; unclassified specificity.
SVWCSingle domain von Willebrand factor type C
SWAPSuppressor-of-White-APricot splicing regulator
SWIBSWI complex, BAF60b domains
SybindinSybindin-like family
SynNSyntaxin N-terminal domain
t_SNAREHelical region found in SNAREs
TAFTATA box binding protein associated factor
TAFHTAF homology
TAFII55_NTAFII55 protein conserved region
TANTelomere-length maintenance and DNA damage repair
Tankyrase_bdg_CTankyrase binding protein C terminal domain
TAP_CC-terminal domain of vertebrate Tap protein
TarHHomologues of the ligand binding domain of Tar
TBCDomain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs.
Tbf5Transcription factor TFIIH complex subunit Tfb5
TBOXDomain first found in the mice T locus (Brachyury) protein
TDUShort repeats in human TONDU, fly vestigial and other proteins.
TEATEA domain
TECPRBeta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins.
Telo_bindTelomeric single stranded DNA binding POT1/CDC13
Telomerase_RBDTelomerase ribonucleoprotein complex - RNA binding domain
Tet_JBPOxygenase domain of the 2OGFeDO superfamily
TFIIATranscription factor IIA, alpha/beta subunit
TFIIETranscription initiation factor IIE
TFS2MDomain in the central regions of transcription elongation factor S-II (and elsewhere)
TFS2NDomain in the N-terminus of transcription elongation factor S-II (and elsewhere)
TGcTransglutaminase/protease-like homologues
TGFBTransforming growth factor-beta (TGF-beta) family
THEGRepeats in THEG (testicular haploid expressed gene) and several fly proteins.
Thiol-ester_clAlpha-macro-globulin thiol-ester bond-forming region
THNThaumatin family
THYThymosin beta actin-binding motif.
TilS_CTilS substrate C-terminal domain
TIRToll - interleukin 1 - resistance
TKTachykinin family
TLCTRAM, LAG1 and CLN8 homology domains.
TLDcdomain in TBC and LysM domain containing proteins
Tn7_Tnp_TnsA_NPD-(D/E)XK nuclease transposase sub-family
TNFTumour necrosis factor family.
TNFRTumor necrosis factor receptor / nerve growth factor receptor repeats.
TnpAsub-family of tyrosine recombinases
TnpRsub-family of tyrosine recombinases
TOP1AcBacterial DNA topoisomerase I DNA-binding domain
TOP1BcBacterial DNA topoisomeraes I ATP-binding domain
TOP4cDNA Topoisomerase IV
TOPEUcDNA Topoisomerase I (eukaryota)
TPK_B1_bindingThiamin pyrophosphokinase, vitamin B1 binding domain
TPRTetratricopeptide repeats
Trans_reg_CTranscriptional regulatory protein, C terminal
Transket_pyrTransketolase, pyrimidine binding domain
Transposase_20transposase sub-family
Transposase_21DDE transposase sub-family
Transposase_31PD-(D/E)XK nuclease transposase sub-family
Transposase_mutDDE transposase sub-family
TRASHmetallochaperone-like domain
tRNA_SADThreonyl and Alanyl tRNA synthetase second additional domain
TRP_2Transient receptor ion channel II
TRP_NML-like domain
TrwCHUH conjugative element mobility domain
Tryp_SPcTrypsin-like serine protease
TSP1Thrombospondin type 1 repeats
TSPctail specific protease
TSPNThrombospondin N-terminal -like domains.
TubulinTubulin/FtsZ family, GTPase domain
Tubulin_CTubulin/FtsZ family, C-terminal domain
TUDORTudor domain
TYThyroglobulin type I repeats.
TYRfamily involved in site-specific recombination, contains conserved tyrosine residue invovled in catalysis
TyrKcTyrosine kinase, catalytic domain
UBAUbiquitin associated domain
UBA_e1_CUbiquitin-activating enzyme e1 C-terminal domain
UBCcUbiquitin-conjugating enzyme E2, catalytic domain homologues
UboxModified RING finger domain
UBQUbiquitin homologues
UBXDomain present in ubiquitin-regulatory proteins
uDENNDomain always found upstream of DENN domain, found in a variety of signalling proteins
UDGUracil DNA glycosylase superfamily
UDPG_MGDP_dh_CUDP binding domain
UIMUbiquitin-interacting motif.
UMEDomain in UVSB PI-3 kinase, MEI-41 and ESR-1
UreE_CUreE urease accessory protein, C-terminal domain
UreE_NUreE urease accessory protein, N-terminal domain
VHPVillin headpiece domain
VHSDomain present in VPS-27, Hrs and STAM
Viral_RepHUH phage replication sub-family
VITVault protein Inter-alpha-Trypsin domain
VPS9Domain present in VPS9
VWAvon Willebrand factor (vWF) type A domain
VWCvon Willebrand factor (vWF) type C domain
VWC_outvon Willebrand factor (vWF) type C domain
VWDvon Willebrand factor (vWF) type D domain
WAPFour-disulfide core domains
WD40WD40 repeats
WGRProposed nucleic acid binding domain
WH1WASP homology region 1
WH2Wiskott Aldrich syndrome homology region 2
WHyWater Stress and Hypersensitive response
WIFWnt-inhibitory factor-1 like domain
WNT1found in Wnt-1
WR1Worm-specific repeat type 1
WRKYDNA binding domain
WSCpresent in yeast cell wall integrity and stress response component proteins
WSNWorm-specific (usually) N-terminal domain
WWDomain with 2 conserved Trp (W) residues
WWEDomain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis.
X8Possibly involved in carbohydrate binding
Xersub-family of tyrosine recombinases
XPGIXeroderma pigmentosum G I-region
XPGNXeroderma pigmentosum G N-region
XTALbgBeta/gamma crystallins
Y1_TnpTransposase IS200 like
YajCPreprotein translocase subunit
YccV-likeHemimethylated DNA-binding protein YccV like
YceIYceI-like domain
YL1_CYL1 nuclear protein C-terminal domain
YqgFcLikely ribonuclease with RNase H fold.
ZalphaZ-DNA-binding domain in adenosine deaminases.
Zds_CActivator of mitotic machinery Cdc14 phosphatase activation C-term
zf-3CxxCZinc-binding domain
zf-ADZinc-finger associated domain (zf-AD)
zf-C4_ClpXClpX C4-type zinc finger
zf-PARPPoly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
ZipA_CZipA, C-terminal domain (FtsZ-binding)
ZMZASP-like motif
Zn_dep_PLPCZinc dependent phospholipase C (alpha toxin)
ZnF_A20A20-like zinc fingers
ZnF_AN1AN1-like Zinc finger
ZnF_BEDBED zinc finger
ZnF_C2C2C2C2 Zinc finger
ZnF_C2H2zinc finger
ZnF_C2HCzinc finger
ZnF_C3H1zinc finger
ZnF_C4c4 zinc finger in nuclear hormone receptors
ZnF_CDGSHCDGSH-type zinc finger. Function unknown.
ZnF_CHCCzinc finger
ZnF_DBFZinc finger in DBF-like proteins
ZnF_GATAzinc finger binding to DNA consensus sequence [AT]GATA[AG]
ZnF_PMZplant mutator transposase zinc finger
ZnF_Rad18Rad18-like CCHC zinc finger
ZnF_RBZZinc finger domain
ZnF_TAZTAZ zinc finger, present in p300 and CBP
ZnF_U1U1-like zinc finger
ZnF_UBPUbiquitin Carboxyl-terminal Hydrolase-like zinc finger
ZnF_UBR1Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
ZnF_ZZZinc-binding domain, present in Dystrophin, CREB-binding protein.
ZnMcZinc-dependent metalloprotease
ZPZona pellucida (ZP) domain
Zpr1Duplicated domain in the epidermal growth factor- and elongation factor-1alpha-binding protein Zpr1. Also present in archaeal proteins.
ZU5Domain present in ZO-1 and Unc5-like netrin receptors