The domain within your query sequence starts at position 1938 and ends at position 2123; the E-value for the AAA domain shown below is 3.04e-7.
PGECFGLLGVNGAGKSTTFKMLTGDTPVTRGDAFLNKNSILSNIHEVHQNMGYCPQFDAI TELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYASNYSGGNKRKLSTAM ALIGGPPVVFLDEPTTGMDPKARRFLWNCALSIVKEGRSVVLTSHSMEECEALCTRMAIM VNGRFR
AAAATPases associated with a variety of cellular activities |
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SMART accession number: | SM00382 |
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Description: | AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment. |
Interpro abstract (IPR003593): | The AAA+ superfamily of ATPases is found in all kingdoms of living organisms where they participate in diverse cellular processes including membrane fusion, proteolysis and DNA replication. Although the terms AAA+ and AAA are often used loosely and interchangeably, the classical AAA family members are distinguished by their possession of the SRH region in the AAA module. Many AAA+ proteins are involved in similar processes to those of AAA proteins (facilitation of protein folding and unfolding, assembly or disassembly of proteins complexes, protein transport and degradation), but others function in replication, recombination, repair and transcription. For a review see [ (PUBMED:11473577) ]. The proteins in this superfamily are characterised by the structural conservation of a central ATPase domain of about 250 amino acids called the AAA+ module. Typically, the AAA+ domain can be divided into two structural subdomains, an N-terminal P-loop NTPase alpha-beta-alpha subdomain that is connected to a smaller C-terminal all-alpha subdomain. The alpha-beta-alpha subdomain adopts a Rossman fold and contains several motifs involved in ATP binding and hydrolysis, including classical motifs Walker A and Walker B [ (PUBMED:11473577) (PUBMED:18466635) ]. The all-alpha subdomain [ (PUBMED:9927482) ], is much less conserved across AAA+ proteins. |
Family alignment: |
There are 2804801 AAA domains in 2428284 proteins in SMART's nrdb database.
Click on the following links for more information.
- Evolution (species in which this domain is found)
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Taxonomic distribution of proteins containing AAA domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with AAA domain is also avaliable.
Click on the protein counts, or double click on taxonomic names to display all proteins containing AAA domain in the selected taxonomic class.
- Literature (relevant references for this domain)
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Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
- Neuwald AF, Aravind L, Spouge JL, Koonin EV
- AAA+: A class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes.
- Genome Res. 1999; 9: 27-43
- Display abstract
Using a combination of computer methods for iterative database searches and multiple sequence alignment, we show that protein sequences related to the AAA family of ATPases are far more prevalent than reported previously. Among these are regulatory components of Lon and Clp proteases, proteins involved in DNA replication, recombination, and restriction (including subunits of the origin recognition complex, replication factor C proteins, MCM DNA-licensing factors and the bacterial DnaA, RuvB, and McrB proteins), prokaryotic NtrC-related transcription regulators, the Bacillus sporulation protein SpoVJ, Mg2+, and Co2+ chelatases, the Halobacterium GvpN gas vesicle synthesis protein, dynein motor proteins, TorsinA, and Rubisco activase. Alignment of these sequences, in light of the structures of the clamp loader delta' subunit of Escherichia coli DNA polymerase III and the hexamerization component of N-ethylmaleimide-sensitive fusion protein, provides structural and mechanistic insights into these proteins, collectively designated the AAA+ class. Whole-genome analysis indicates that this class is ancient and has undergone considerable functional divergence prior to the emergence of the major divisions of life. These proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes. The hexameric architecture often associated with this class can provide a hole through which DNA or RNA can be thread; this may be important for assembly or remodeling of DNA-protein complexes.
- Lenzen CU, Steinmann D, Whiteheart SW, Weis WI
- Crystal structure of the hexamerization domain of N-ethylmaleimide-sensitive fusion protein.
- Cell. 1998; 94: 525-36
- Display abstract
N-ethylmaleimide-sensitive fusion protein (NSF) is a cytosolic ATPase required for many intracellular vesicle fusion reactions. NSF consists of an amino-terminal region that interacts with other components of the vesicle trafficking machinery, followed by two homologous ATP-binding cassettes, designated D1 and D2, that possess essential ATPase and hexamerization activities, respectively. The crystal structure of D2 bound to Mg2+-AMPPNP has been determined at 1.75 A resolution. The structure consists of a nucleotide-binding and a helical domain, and it is unexpectedly similar to the first two domains of the clamp-loading subunit delta' of E. coli DNA polymerase III. The structure suggests several regions responsible for coupling of ATP hydrolysis to structural changes in full-length NSF.
- Patel S, Latterich M
- The AAA team: related ATPases with diverse functions.
- Trends Cell Biol. 1998; 8: 65-71
- Display abstract
A new family of related ATPases has emerged, characterized by a highly conserved AAA motif. This motif forms a 230-amino-acid domain that contains Walker homology sequences and imparts ATPase activity. Homology between AAA-family members is confined mostly to the AAA domain, although additional homology outside the AAA motif is present among closely related proteins. AAA proteins act in a variety of cellular functions, including cell-cycle regulation, protein degradation, organelle biogenesis and vesicle-mediated protein transport. The AAA domain is required for protein function, but its exact role and the specific activity that it confers on AAA proteins is still unclear. This review describes current understanding of the AAA protein family.
- Disease (disease genes where sequence variants are found in this domain)
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SwissProt sequences and OMIM curated human diseases associated with missense mutations within the AAA domain.
Protein Disease Peroxisome biogenesis factor 1 (O43933) (SMART) OMIM:602136: Zellweger syndrome-1
OMIM:214100: Adrenoleukodystrophy, neonatal
OMIM:202370: Refsum disease, infantile
OMIM:266510:ATP-binding cassette sub-family D member 1 (P33897) (SMART) OMIM:300100: Adrenoleukodystrophy ; Adrenomyeloneuropathy Cystic fibrosis transmembrane conductance regulator (P13569) (SMART) OMIM:602421: Cystic fibrosis
OMIM:219700: Congenital bilateral absence of vas deferens
OMIM:277180: Sweat chloride elevation without CF ; {Pancreatitis, idiopathic} ; {Hypertrypsinemia, neonatal}ATP-binding cassette sub-family C member 8 (Q09428) (SMART) OMIM:600509: Persistent hyperinsulinemic hypoglycemia of infancy
OMIM:256450:Spastin (Q9UBP0) (SMART) OMIM:182601: Spastic paraplegia-4
OMIM:604277: Spastic paraplegia-4
OMIM:182601:ATP-binding cassette sub-family A member 1 (O95477) (SMART) OMIM:600046: Tangier disease
OMIM:205400: HDL deficiency, familial
OMIM:604091:Antigen peptide transporter 1 (Q03518) (SMART) OMIM:170260: TRANSPORTER, ATP-BINDING CASSETTE, MAJOR HISTOCOMPATIBILITY COMPLEX DNA repair protein RAD51 homolog 1 (Q06609) (SMART) OMIM:179617: {Breast cancer, susceptibility to}
OMIM:114480:Canalicular multispecific organic anion transporter 1 (Q92887) (SMART) OMIM:601107: Dubin-Johnson syndrome
OMIM:237500:Antigen peptide transporter 2 (Q03519) (SMART) OMIM:170261: Bare lymphocyte syndrome, type I, due to TAP2 deficiency Peroxisome assembly factor 2 (Q13608) (SMART) OMIM:601498: Peroxisomal biogenesis disorder, complementation group 4 Retinal-specific ATP-binding cassette transporter (P78363) (SMART) OMIM:601691: Stargardt disease-1
OMIM:248200: Retinitis pigmentosa-19
OMIM:601718: Cone-rod dystrophy 3 ; Macular dystrophy, age-related, 2
OMIM:153800: Fundus flavimaculatus
OMIM:248200: - Metabolism (metabolic pathways involving proteins which contain this domain)
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Click the image to view the interactive version of the map in iPath% proteins involved KEGG pathway ID Description 72.32 map02010 ABC transporters - General 4.51 map03060 Protein export 3.93 map03030 DNA replication 3.06 map03090 Type II secretion system 2.69 map00190 Oxidative phosphorylation 1.92 map00195 Photosynthesis 1.85 map02020 Two-component system - General 1.57 map02040 Flagellar assembly 1.26 map03070 Type III secretion system 1.06 map00910 Nitrogen metabolism 0.87 map03050 Proteasome 0.79 map00790 Folate biosynthesis 0.75 map00860 Porphyrin and chlorophyll metabolism 0.67 map00500 Starch and sucrose metabolism 0.57 map04111 Cell cycle - yeast 0.56 map04110 Cell cycle 0.37 map00230 Purine metabolism 0.27 map03080 Type IV secretion system 0.15 map00240 Pyrimidine metabolism 0.14 map05212 Pancreatic cancer 0.11 map04310 Wnt signaling pathway 0.07 map04612 Antigen processing and presentation 0.06 map00400 Phenylalanine, tyrosine and tryptophan biosynthesis 0.06 map00920 Sulfur metabolism 0.06 map00450 Selenoamino acid metabolism 0.05 map00730 Thiamine metabolism 0.05 map04930 Type II diabetes mellitus 0.03 map00780 Biotin metabolism 0.03 map00310 Lysine degradation 0.02 map05120 Epithelial cell signaling in Helicobacter pylori infection 0.02 map00440 Aminophosphonate metabolism 0.02 map00540 Lipopolysaccharide biosynthesis 0.01 map00010 Glycolysis / Gluconeogenesis 0.01 map00271 Methionine metabolism 0.01 map00770 Pantothenate and CoA biosynthesis 0.01 map00260 Glycine, serine and threonine metabolism 0.01 map00350 Tyrosine metabolism 0.01 map00251 Glutamate metabolism 0.01 map00650 Butanoate metabolism 0.01 map00120 Bile acid biosynthesis 0.01 map00710 Carbon fixation 0.01 map00460 Cyanoamino acid metabolism 0.01 map00632 Benzoate degradation via CoA ligation 0.01 map00564 Glycerophospholipid metabolism 0.01 map00300 Lysine biosynthesis 0.01 map00903 Limonene and pinene degradation 0.01 map00624 1- and 2-Methylnaphthalene degradation 0.01 map00630 Glyoxylate and dicarboxylate metabolism 0.01 map00480 Glutathione metabolism 0.01 map00550 Peptidoglycan biosynthesis 0.01 map00362 Benzoate degradation via hydroxylation 0.01 map00272 Cysteine metabolism 0.01 map00030 Pentose phosphate pathway This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with AAA domain which could be assigned to a KEGG orthologous group, and not all proteins containing AAA domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.
- Structure (3D structures containing this domain)
3D Structures of AAA domains in PDB
PDB code Main view Title 1b0u ATP-BINDING SUBUNIT OF THE HISTIDINE PERMEASE FROM SALMONELLA TYPHIMURIUM 1bmf BOVINE MITOCHONDRIAL F1-ATPASE 1cow BOVINE MITOCHONDRIAL F1-ATPASE COMPLEXED WITH AUROVERTIN B 1d2n D2 DOMAIN OF N-ETHYLMALEIMIDE-SENSITIVE FUSION PROTEIN 1do0 ORTHORHOMBIC CRYSTAL FORM OF HEAT SHOCK LOCUS U (HSLU) FROM ESCHERICHIA COLI 1do2 TRIGONAL CRYSTAL FORM OF HEAT SHOCK LOCUS U (HSLU) FROM ESCHERICHIA COLI 1e1q BOVINE MITOCHONDRIAL F1-ATPASE AT 100K 1e1r BOVINE MITOCHONDRIAL F1-ATPASE INHIBITED BY MG2+ADP AND ALUMINIUM FLUORIDE 1e32 Structure of the N-Terminal domain and the D1 AAA domain of membrane fusion ATPase p97 1e69 SMC head domain from Thermotoga maritima 1e79 Bovine F1-ATPase inhibited by DCCD (dicyclohexylcarbodiimide) 1e94 HslV-HslU from E.coli 1efr BOVINE MITOCHONDRIAL F1-ATPASE COMPLEXED WITH THE PEPTIDE ANTIBIOTIC EFRAPEPTIN 1f3o Crystal structure of MJ0796 ATP-binding cassette 1f48 CRYSTAL STRUCTURE OF THE ESCHERICHIA COLI ARSENITE-TRANSLOCATING ATPASE 1ffh N AND GTPASE DOMAINS OF THE SIGNAL SEQUENCE RECOGNITION PROTEIN FFH FROM THERMUS AQUATICUS 1fnn CRYSTAL STRUCTURE OF CDC6P FROM PYROBACULUM AEROPHILUM 1fts SIGNAL RECOGNITION PARTICLE RECEPTOR FROM E. COLI 1fx0 Crystal structure of the chloroplast F1-ATPase from spinach 1g18 RECA-ADP-ALF4 COMPLEX 1g19 STRUCTURE OF RECA PROTEIN 1g29 MALK 1g3i CRYSTAL STRUCTURE OF THE HSLUV PROTEASE-CHAPERONE COMPLEX 1g41 CRYSTAL STRUCTURE OF HSLU HAEMOPHILUS INFLUENZAE 1g4a CRYSTAL STRUCTURES OF THE HSLVU PEPTIDASE-ATPASE COMPLEX REVEAL AN ATP-DEPENDENT PROTEOLYSIS MECHANISM 1g4b CRYSTAL STRUCTURES OF THE HSLVU PEPTIDASE-ATPASE COMPLEX REVEAL AN ATP-DEPENDENT PROTEOLYSIS MECHANISM 1g6h CRYSTAL STRUCTURE OF THE ADP CONFORMATION OF MJ1267, AN ATP-BINDING CASSETTE OF AN ABC TRANSPORTER 1g8p CRYSTAL STRUCTURE OF BCHI SUBUNIT OF MAGNESIUM CHELATASE 1g8y CRYSTAL STRUCTURE OF THE HEXAMERIC REPLICATIVE HELICASE REPA OF PLASMID RSF1010 1g9x CHARACTERIZATION OF THE TWINNING STRUCTURE OF MJ1267, AN ATP-BINDING CASSETTE OF AN ABC TRANSPORTER 1gaj CRYSTAL STRUCTURE OF A NUCLEOTIDE-FREE ATP-BINDING CASSETTE FROM AN ABC TRANSPORTER 1h8e (ADP.AlF4)2(ADP.SO4) bovine F1-ATPase (all three catalytic sites occupied) 1h8h Bovine mitochondrial F1-Atpase at 100K 1hqc STRUCTURE OF RUVB FROM THERMUS THERMOPHILUS HB8 1hqy Nucleotide-Dependent Conformational Changes in a Protease-Associated ATPase HslU 1ht1 Nucleotide-Dependent Conformational Changes in a Protease-Associated ATPase HslU 1ht2 Nucleotide-Dependent Conformational Changes in a Protease-Associated ATPase HslU 1ihu CRYSTAL STRUCTURE OF THE ESCHERICHIA COLI ARSENITE-TRANSLOCATING ATPASE IN COMPLEX WITH MG-ADP-ALF3 1ii0 CRYSTAL STRUCTURE OF THE ESCHERICHIA COLI ARSENITE-TRANSLOCATING ATPASE 1ii9 CRYSTAL STRUCTURE OF THE ESCHERICHIA COLI ARSENITE-TRANSLOCATING ATPASE IN COMPLEX WITH AMP-PNP 1im2 HslU, Haemophilus Influenzae, Selenomethionine Variant 1in4 THERMOTOGA MARITIMA RUVB HOLLIDAY JUNCTION BRANCH MIGRATION MOTOR 1in5 THERMOGOTA MARITIMA RUVB A156S MUTANT 1in6 THERMOTOGA MARITIMA RUVB K64R MUTANT 1in7 THERMOTOGA MARITIMA RUVB R170A 1in8 THERMOTOGA MARITIMA RUVB T158V 1iqp Crystal Structure of the Clamp Loader Small Subunit from Pyrococcus furiosus 1ixr RuvA-RuvB complex 1ixs Structure of RuvB complexed with RuvA domain III 1ixz Crystal structure of the FtsH ATPase domain from Thermus thermophilus 1iy0 Crystal structure of the FtsH ATPase domain with AMP-PNP from Thermus thermophilus 1iy1 Crystal structure of the FtsH ATPase domain with ADP from Thermus thermophilus 1iy2 Crystal structure of the FtsH ATPase domain from Thermus thermophilus 1j7k THERMOTOGA MARITIMA RUVB P216G MUTANT 1j8m Signal Recognition Particle conserved GTPase domain from A. ambivalens 1j8y Signal Recognition Particle conserved GTPase domain from A. ambivalens T112A mutant 1jbk Crystal Structure of the First Nucelotide Binding Domain of ClpB 1ji0 Crystal Structure Analysis of the ABC transporter from Thermotoga maritima 1jj7 Crystal Structure of the C-terminal ATPase domain of human TAP1 1jpj GMPPNP Complex of SRP GTPase NG Domain 1jpn GMPPNP Complex of SRP GTPase NG Domain 1jr3 Crystal Structure of the Processivity Clamp Loader Gamma Complex of E. coli DNA Polymerase III 1kmh Crystal Structure of spinach chloroplast F1-ATPase complexed with tentoxin 1ksf Crystal Structure of ClpA, an HSP100 chaperone and regulator of ClpAP protease: Structural basis of differences in Function of the Two AAA+ ATPase domains 1kyi HslUV (H. influenzae)-NLVS Vinyl Sulfone Inhibitor Complex 1l2t Dimeric Structure of MJ0796, a Bacterial ABC Transporter Cassette 1l7v Bacterial ABC Transporter Involved in B12 Uptake 1l8q CRYSTAL STRUCTURE OF DNA REPLICATION INITIATION FACTOR 1ls1 T. aquaticus Ffh NG Domain at 1.1A Resolution 1lv7 Crystal Structure of the AAA domain of FtsH 1mab RAT LIVER F1-ATPASE 1mo3 RECA-ADP COMPLEX 1mo4 RECA-ATP-GAMMA-S COMPLEX 1mo5 RECA-ATP-GAMMA-S-MG COMPLEX 1mo6 RECA-DATP-MG COMPLEX 1mt0 ATP-binding domain of haemolysin B from Escherichia coli 1mv5 Crystal structure of LmrA ATP-binding domain 1n03 Model for Active RecA Filament 1n0w Crystal structure of a RAD51-BRCA2 BRC repeat complex 1nbm THE STRUCTURE OF BOVINE F1-ATPASE COVALENTLY INHIBITED WITH 4-CHLORO-7-NITROBENZOFURAZAN 1ng1 N AND GTPASE DOMAINS OF THE SIGNAL SEQUENCE RECOGNITION PROTEIN FFH FROM THERMUS AQUATICUS 1njf Nucleotide bound form of an isolated E. coli clamp loader gamma subunit 1njg Nucleotide-free form of an Isolated E. coli Clamp Loader Gamma Subunit 1nlf Crystal Structure of DNA Helicase RepA in complex with sulfate at 1.95 A resolution 1nsf D2 HEXAMERIZATION DOMAIN OF N-ETHYLMALEIMIDE SENSITIVE FACTOR (NSF) 1ny5 Crystal structure of sigm54 activator (AAA+ ATPase) in the inactive state 1ny6 Crystal structure of sigm54 activator (AAA+ ATPase) in the active state 1o87 A new MgGDP complex of the Ffh NG domain 1ofh Asymmetric complex between HslV and I-domain deleted HslU (H. influenzae) 1ofi Asymmetric complex between HslV and I-domain deleted HslU (H. influenzae) 1ohh BOVINE MITOCHONDRIAL F1-ATPASE complexed with the inhibitor protein IF1 1ojl Crystal structure of a sigma54-activator suggests the mechanism for the conformational switch necessary for sigma54 binding 1okk HOMO-HETERODIMERIC COMPLEX OF THE SRP GTPASES 1olo Hexameric Replicative DNA Helicase RepA from Plasmid RSF1010 - Cubic Crystal Structure 1oxs Crystal structure of GlcV, the ABC-ATPase of the glucose ABC transporter from Sulfolobus solfataricus 1oxt Crystal structure of GlcV, the ABC-ATPase of the glucose ABC transporter from Sulfolobus solfataricus 1oxu Crystal structure of GlcV, the ABC-ATPase of the glucose ABC transporter from Sulfolobus solfataricus 1oxv Crystal structure of GlcV, the ABC-ATPase of the glucose ABC transporter from Sulfolobus solfataricus 1oxx Crystal structure of GlcV, the ABC-ATPase of the glucose ABC transporter from Sulfolobus solfataricus 1p9r Crystal Structure of Vibrio cholerae putative NTPase EpsE 1p9w Crystal Structure of Vibrio cholerae putative NTPase EpsE 1pv4 X-ray crystal structure of the Rho transcription termination factor in complex with single stranded DNA 1pvo X-ray crystal structure of Rho transcription termination factor in complex with ssRNA substrate and ANPPNP 1pzn Rad51 (RadA) 1q12 Crystal Structure of the ATP-bound E. coli MalK 1q1b Crystal structure of E. coli MalK in the nucleotide-free form 1q1e The ATPase component of E. coli maltose transporter (MalK) in the nucleotide-free form 1q3h mouse CFTR NBD1 with AMP.PNP 1qo1 Molecular Architecture of the Rotary Motor in ATP Synthase from Yeast Mitochondria 1qvr Crystal Structure Analysis of ClpB 1qzw Crystal structure of the complete core of archaeal SRP and implications for inter-domain communication 1qzx Crystal structure of the complete core of archaeal SRP and implications for inter-domain communication 1r0w Cystic fibrosis transmembrane conductance regulator (CFTR) nucleotide-binding domain one (NBD1) apo 1r0x Cystic fibrosis transmembrane conductance regulator (CFTR) nucleotide-binding domain one (NBD1) with ATP 1r0y Cystic fibrosis transmembrane conductance regulator (CFTR) nucleotide-binding domain one (NBD1) with ADP 1r0z Phosphorylated Cystic fibrosis transmembrane conductance regulator (CFTR) nucleotide-binding domain one (NBD1) with ATP 1r10 Cystic fibrosis transmembrane conductance regulator (CFTR) nucleotide-binding domain one (NBD1) with ATP, I4122 space group 1r6b High resolution crystal structure of ClpA 1r7r The crystal structure of murine p97/VCP at 3.6A 1rea STRUCTURE OF THE RECA PROTEIN-ADP COMPLEX 1rj9 Structure of the heterodimer of the conserved GTPase domains of the Signal Recognition Particle (Ffh) and Its Receptor (FtsY) 1ry1 Structure of the signal recognition particle interacting with the elongation-arrested ribosome 1s3s Crystal structure of AAA ATPase p97/VCP ND1 in complex with p47 C 1sgw Putative ABC transporter (ATP-binding protein) from Pyrococcus furiosus Pfu-867808-001 1sky CRYSTAL STRUCTURE OF THE NUCLEOTIDE FREE ALPHA3BETA3 SUB-COMPLEX OF F1-ATPASE FROM THE THERMOPHILIC BACILLUS PS3 1sxj Crystal Structure of the Eukaryotic Clamp Loader (Replication Factor C, RFC) Bound to the DNA Sliding Clamp (Proliferating Cell Nuclear Antigen, PCNA) 1szp A Crystal Structure of the Rad51 Filament 1t4g ATPase in complex with AMP-PNP 1u94 Crystal Structure of E. Coli RecA in a Compressed Helical Filament Form 2 1u98 ""Crystal Structure of E. coli RecA in a Compressed Helical Filament Form3"" 1u99 ""Crystal Structures of E. coli RecA in a Compressed Helical Filament Form 4"" 1ubc Structure of Reca Protein 1ube MsRecA-ADP Complex 1ubf MsREcA-ATPgS complex 1ubg MsREcA-dATP complex 1um8 Crystal structure of helicobacter pylori ClpX 1v43 Crystal Structure of ATPase subunit of ABC Sugar Transporter 1v5w Crystal structure of the human Dmc1 protein 1vci Crystal structure of the ATP-binding cassette of multisugar transporter from Pyrococcus horikoshii OT3 complexed with ATP 1vdz Crystal structure of A-type ATPase catalytic subunit A from Pyrococcus horikoshii OT3 1vma Crystal structure of Cell division protein ftsY (TM0570) from Thermotoga maritima at 1.60 A resolution 1vpl Crystal structure of ABC transporter ATP-binding protein (TM0544) from Thermotoga maritima at 2.10 A resolution 1w0j Beryllium fluoride inhibited bovine F1-ATPase 1w0k Beryllium fluoride inhibited bovine F1-ATPase 1w36 RecBCD:DNA complex 1xef Crystal structure of the ATP/Mg2+ bound composite dimer of HlyB-NBD 1xf9 Structure of NBD1 from murine CFTR- F508S mutant 1xfa Structure of NBD1 from murine CFTR- F508R mutant 1xmi Crystal structure of human F508A NBD1 domain with ATP 1xmj Crystal structure of human deltaF508 human NBD1 domain with ATP 1xms ""E. Coli RecA in complex with MnAMP-PNP"" 1xmv ""E. Coli RecA in complex with MgADP"" 1xp8 "Deinococcus radiodurans RecA in complex with ATP-gamma-S" 1xpo Structural mechanism of inhibition of the Rho transcription termination factor by the antibiotic bicyclomycin 1xpr Structural mechanism of inhibition of the Rho transcription termination factor by the antibiotic 5a-formylbicyclomycin (FB) 1xpu Structural mechanism of inhibition of the Rho transcription termination factor by the antibiotic 5a-(3-formylphenylsulfanyl)-dihydrobicyclomycin (FPDB) 1xu4 ATPASE IN COMPLEX WITH AMP-PNP, MAGNESIUM AND POTASSIUM CO-F 1xwi Crystal Structure of VPS4B 1xxh ATPgS Bound E. Coli Clamp Loader Complex 1xxi ADP Bound E. coli Clamp Loader Complex 1ye8 Crystal Structure of THEP1 from the hyperthermophile Aquifex aeolicus 1yqt RNase-L Inhibitor 1yr6 PAB0955 crystal structure : a GTPase in Apo form from Pyrococcus abyssi 1yr7 PAB0955 crystal structure : a GTPase in GTP-gamma-S bound form from Pyrococcus abyssi 1yr8 PAB0955 crystal structure : a GTPase in GTP bound form from Pyrococcus abyssi 1yr9 PAB0955 crystal structure : a GTPase in GDP and PO4 bound form from Pyrococcus abyssi 1yra PAB0955 crystal structure : a GTPase in GDP bound form from Pyrococcus abyssi 1yrb PAB0955 crystal structure : a GTPase in GDP and Mg bound form from Pyrococcus abyssi 1yyf Correction of X-ray Intensities from an HslV-HslU co-crystal containing lattice translocation defects 1z47 Structure of the ATPase subunit CysA of the putative sulfate ATP-binding cassette (ABC) transporter from Alicyclobacillus acidocaldarius 1zu4 Crystal structure of FtsY from Mycoplasma mycoides- space group P21212 1zu5 Crystal structure of FtsY from Mycoplasma mycoides- space group H32 2awn Crystal structure of the ADP-Mg-bound E. Coli MALK (Crystallized with ATP-Mg) 2awo Crystal structure of the ADP-Mg-bound E. Coli MALK (Crystallized with ADP-Mg) 2b21 RADA Recombinase in complex with AMPPNP at pH 6.0 2bbo Human NBD1 with Phe508 2bbs Human deltaF508 NBD1 with three solubilizing mutations 2bbt Human deltaF508 NBD1 with two solublizing mutations. 2bjv Crystal Structure of PspF(1-275) R168A mutant 2bjw PspF AAA domain 2bke Conformational Flexibility Revealed by the Crystal Structure of a Crenarchaeal RadA 2c03 GDP COMPLEX OF SRP GTPASE FFH NG DOMAIN 2c04 GMPPCP complex of SRP GTPase Ffh NG Domain at ultra-high resolution 2c96 Structural basis of the nucleotide driven conformational changes in the AAA domain of transcription activator PspF 2c98 Structural basis of the nucleotide driven conformational changes in the AAA domain of transcription activator PspF 2c99 Structural basis of the nucleotide driven conformational changes in the AAA domain of transcription activator PspF 2c9c Structural basis of the nucleotide driven conformational changes in the AAA domain of transcription activator PspF 2c9o 3D Structure of the human RuvB-like helicase RuvBL1 2cbz Structure of the human Multidrug Resistance Protein 1 Nucleotide Binding Domain 1 2ce7 EDTA treated 2cea wildtype 2chg Replication Factor C domains 1 and 2 2chq Replication Factor C ADPNP complex 2chv Replication Factor C ADPNP complex 2ck3 Azide inhibited bovine F1-ATPase 2cnw GDPALF4 complex of the SRP GTPases Ffh and FtsY 2d3w Crystal Structure of Escherichia coli SufC, an ATPase compenent of the SUF iron-sulfur cluster assembly machinery 2d62 Crystal structure of multiple sugar binding transport ATP-binding protein 2dfl Crystal structure of left-handed RadA filament 2dhr Whole cytosolic region of ATP-dependent metalloprotease FtsH (G399L) 2dpy Crystal structure of the flagellar type III ATPase FliI 2dr3 Crystal Structure of RecA superfamily ATPase PH0284 from Pyrococcus horikoshii OT3 2ewv Crystal Structure of the Pilus Retraction Motor PilT and Bound ADP 2eww Crystal Structure of the Pilus Retraction Motor PilT and Bound ATP 2eyu The Crystal Structure of the C-terminal Domain of Aquifex aeolicus PilT 2f1h RECOMBINASE IN COMPLEX WITH AMP-PNP and Potassium 2f1i Recombinase in Complex with AMP-PNP 2f1j Recombinase in Complex with ADP 2f43 Rat liver F1-ATPase 2ff7 The ABC-ATPase of the ABC-transporter HlyB in the ADP bound state 2ffa Crystal structure of ABC-ATPase H662A of the ABC-transporter HlyB in complex with ADP 2ffb The crystal structure of the HlyB-NBD E631Q mutant in complex with ADP 2ffh THE SIGNAL SEQUENCE BINDING PROTEIN FFH FROM THERMUS AQUATICUS 2fgj Crystal structure of the ABC-cassette H662A mutant of HlyB with bound ATP 2fgk Crystal structure of the ABC-cassette E631Q mutant of HlyB with bound ATP 2fpk RadA recombinase in complex with ADP 2fpl RadA recombinase in complex with AMP-PNP and low concentration of K+ 2fpm RadA recombinase in complex with AMP-PNP and high concentration of K+ 2g88 MSRECA-dATP COMPLEX 2gdj Delta-62 RADA recombinase in complex with AMP-PNP and magnesium 2ghi Crystal Structure of Plasmodium yoelii Multidrug Resistance Protein 2 2gsz Structure of A. aeolicus PilT with 6 monomers per asymmetric unit 2hcb Structure of AMPPCP-bound DnaA from Aquifex aeolicus 2hld Crystal structure of yeast mitochondrial F1-ATPase 2ht1 The closed ring structure of the Rho transcription termination factor in complex with nucleic acid in the motor domains 2hyd Multidrug ABC transporter SAV1866 2i1q RadA Recombinase in complex with Calcium 2ihy Structure of the Staphylococcus aureus putative ATPase subunit of an ATP-binding cassette (ABC) transporter 2it1 Structure of PH0203 protein from Pyrococcus horikoshii 2iw3 Elongation Factor 3 in complex with ADP 2iwh Structure of yeast Elongation Factor 3 in complex with ADPNP 2ix3 Structure of yeast Elongation Factor 3 2ix8 Model for eEF3 bound to an 80S ribosome 2ixe Crystal structure of the ATPase domain of TAP1 with ATP (D645N mutant) 2ixf Crystal structure of the ATPase domain of TAP1 with ATP (D645Q, Q678H mutant) 2ixg Crystal structure of the ATPase domain of TAP1 with ATP (S621A, G622V, D645N mutant) 2iy3 Structure of the E. Coli Signal Regognition Particle 2iyl Structure of an FtsY:GDP complex 2j28 Model of E. coli SRP bound to 70S RNCs 2j37 Model of Mammalian SRP bound to 80s RNCs 2j45 Water structure of T. Aquaticus Ffh NG Domain At 1.1A Resolution 2j46 Water structure of T. Aquaticus Ffh NG Domain At 1.1A Resolution 2j7p GMPPNP-stabilized NG domain complex of the SRP GTPases Ffh and FtsY 2jdi Ground state structure of F1-ATPase from bovine heart mitochondria ( Bovine F1-ATPase crystallised in the absence of azide) 2jiz The Structures of F1-ATPase inhibited by resveratrol, piceatannol and quercetin. 2jj1 The Structure of F1-ATPase inhibited by piceatannol. 2jj2 The Structure of F1-ATPase inhibited by quercetin. 2ng1 N AND GTPASE DOMAINS OF THE SIGNAL SEQUENCE RECOGNITION PROTEIN FFH FROM THERMUS AQUATICUS 2nq2 An inward-facing conformation of a putative metal-chelate type ABC transporter. 2o5v Recombination mediator RecF 2obl Structural and biochemical analysis of a prototypical ATPase from the type III secretion system of pathogenic bacteria 2obm Structural and biochemical analysis of a prototypical ATPase from the type III secretion system of pathogenic bacteria 2odn MSRECA-dATP complex 2odw MSrecA-ATP-GAMA-S complex 2oe2 MSrecA-native-low humidity 95% 2oep MSrecA-ADP-complex 2oes MSrecA-native-SSB 2ofo MSrecA-native 2og2 Crystal structure of chloroplast FtsY from Arabidopsis thaliana 2olj ABC Protein ArtP in complex with ADP/Mg2+ 2olk ABC Protein ArtP in complex with ADP-beta-S 2onj Structure of the multidrug ABC transporter Sav1866 from S. aureus in complex with AMP-PNP 2onk ABC transporter ModBC in complex with its binding protein ModA 2ouk ABC Protein ArtP in complex with Sulphate 2oxr PAB0955 crystal structure : a GTPase in GDP and Mg bound form from Pyrococcus abyssi (after GTP hydrolysis) 2p65 Crystal Structure of the first nucleotide binding domain of chaperone ClpB1, putative, (Pv089580) from Plasmodium Vivax 2pcj Crystal structure of ABC transporter (aq_297) From Aquifex Aeolicus VF5 2pcl Crystal structure of ABC transporter with complex (aq_297) from aquifex aeolicus VF5 2pjz The crystal structure of putative Cobalt transport ATP-binding protein (cbiO-2), ST1066 2pmk Crystal structures of an isolated ABC-ATPase in complex with TNP-ADP 2pze Minimal human CFTR first nucleotide binding domain as a head-to-tail dimer 2pzf Minimal human CFTR first nucleotide binding domain as a head-to-tail dimer with delta F508 2pzg Minimal human CFTR first nucleotide binding domain as a monomer 2q0h ABC Protein ArtP in complex with ADP/Mg2+, ATP-gamma-S hydrolyzed 2q9a Structure of Apo FTSY 2q9b Structure of FTSY:GMPPNP Complex 2q9c Structure of FTSY:GMPPNP with MGCL Complex 2qby Crystal structure of a heterodimer of Cdc6/Orc1 initiators bound to origin DNA (from S. solfataricus) 2qe7 Crystal structure of the f1-atpase from the thermoalkaliphilic bacterium bacillus sp. ta2.a1 2qi9 ABC-transporter BtuCD in complex with its periplasmic binding protein BtuF 2qp9 Crystal Structure of S.cerevisiae Vps4 2qpa Crystal Structure of S.cerevisiae Vps4 in the presence of ADP 2qy9 Structure of the NG+1 construct of the E. coli SRP receptor FtsY 2qz4 Human paraplegin, AAA domain in complex with ADP 2r62 Crystal structure of Helicobacter pylori ATP dependent protease, FtsH 2r65 Crystal structure of Helicobacter pylori ATP dependent protease, FtsH ADP complex 2r6a Crystal Form BH1 2r6c Crystal Form BH2 2r6d Crystal Form B1 2r6e Crystal Form B2 2r6f Crystal Structure of Bacillus stearothermophilus UvrA 2r6g The Crystal Structure of the E. coli Maltose Transporter 2reb THE STRUCTURE OF THE E. COLI RECA PROTEIN MONOMER AND POLYMER 2rec RECA HEXAMER MODEL, ELECTRON MICROSCOPY 2rko Crystal Structure of the Vps4p-dimer 2v1u STRUCTURE OF THE AEROPYRUM PERNIX ORC1 PROTEIN IN COMPLEX WITH DNA 2v3c Crystal structure of the SRP54-SRP19-7S.S SRP RNA complex of M. jannaschii 2v7q The structure of F1-ATPase inhibited by I1-60HIS, a monomeric form of the inhibitor protein, IF1. 2vii PspF1-275-Mg-AMP 2vye Crystal Structure of the DnaC-ssDNA complex 2vyf Crystal Structure of the DnaC 2w0m Crystal Structure of sso2452 from Sulfolobus solfataricus P2 2w58 Crystal Structure of the DnaI 2w6e Low resolution structures of bovine mitochondrial F1-ATPase during controlled dehydration:hydration state 1. 2w6f Low resolution structures of bovine mitochondrial F1-ATPase during controlled dehydration: Hydration State 2. 2w6g Low resolution structures of bovine mitochondrial F1-ATPase during controlled dehydration: Hydration State 3. 2w6h Low resolution structures of bovine mitochondrial F1-ATPase during controlled dehydration: Hydration State 4A. 2w6i Low resolution structures of bovine mitochondrial F1-ATPase during controlled dehydration: Hydration State 4B. 2w6j Low resolution structures of bovine mitochondrial F1-ATPase during controlled dehydration: Hydration State 5. 2wpd The Mg.ADP inhibited state of the yeast F1c10 ATP synthase 2wss The structure of the membrane extrinsic region of bovine ATP synthase 2www Crystal Structure of Methylmalonic Acidemia Type A Protein 2x31 Modelling of the complex between subunits BchI and BchD of magnesium chelatase based on single-particle cryo-EM reconstruction at 7.5 ang 2x8a Human Nuclear Valosin containing protein Like (NVL), C-terminal AAA- ATPase domain 2xkv Atomic Model of the SRP-FtsY Early Conformation 2xnd Crystal structure of bovine F1-c8 sub-complex of ATP Synthase 2xok Refined structure of yeast F1c10 ATPase complex to 3 A resolution 2xsz The dodecameric human RuvBL1:RuvBL2 complex with truncated domains II 2xxa The Crystal Structure of the Signal Recognition Particle (SRP) in Complex with its Receptor(SR) 2xzl Upf1-RNA complex 2yhs Structure of the E. coli SRP receptor FtsY 2ykg Structural insights into RNA recognition by RIG-I 2yyz Crystal structure of Sugar ABC transporter, ATP-binding protein 2yz2 Crystal structure of the ABC transporter in the cobalt transport system 2z43 Structure of a twinned crystal of RadA 2z4r Crystal structure of domain III from the Thermotoga maritima replication initiation protein DnaA 2z4s Crystal structure of domain III from the Thermotoga maritima replication initiation protein DnaA 2zam Crystal structure of mouse SKD1/VPS4B apo-form 2zan Crystal structure of mouse SKD1/VPS4B ATP-form 2zao Crystal structure of mouse SKD1/VPS4B ADP-form 2zjb Crystal structure of the human Dmc1-M200V polymorphic variant 2zr0 MSRECA-Q196E mutant 2zr7 Msreca native form II' 2zr9 MsRecA Q196E dATP form IV 2zra MsRecA Q196E ATPgS 2zrb MsRecA Q196E Form II' 2zrc MsRecA Q196N Form IV 2zrd MsRecA Q196N ADP form IV 2zre MsRecA Q196N ATPgS form IV 2zrf MsRecA Q196N dATP form IV 2zrg MsRecA Q196N dATP form II' 2zrh MsRecA Q196A form IV 2zri MsRecA Q196A ADP form IV 2zrj MsRecA Q196A ATPgS form IV 2zrk MsRecA Q196A dATP form IV 2zrl MsRecA Q196A dATP FORM II' 2zrm MsRecA dATP form IV 2zrn MsRecA Form IV 2zro MsRecA ADP form IV 2zrp MsRecA dATP form II' 2zts Crystal structure of KaiC-like protein PH0186 from hyperthermophilic archaea Pyrococcus horikoshii OT3 2zu0 Crystal structure of SufC-SufD complex involved in the iron-sulfur cluster biosynthesis 2zub Left handed RadA 2zuc Crystal structure of left-handed RadA filament 2zud Crystal Structure of Left-handed RadA Filament 3asy ligand-free structure of uridine kinase from thermus thermophilus HB8 3asz CMP-complex structure of uridine kinase from Thermus thermophilus HB8 3aux Crystal structure of Rad50 bound to ADP 3auy Crystal structure of Rad50 bound to ADP 3av0 Crystal structure of Mre11-Rad50 bound to ATP S 3b5j Crystal Structures of the S504A Mutant of an Isolated ABC-ATPase in Complex with TNP-ADP 3b5w Crystal Structure of Eschericia coli MsbA 3b5x Crystal Structure of MsbA from Vibrio cholerae 3b5y Crystal Structure of MsbA from Salmonella typhimurium with AMPPNP 3b5z Crystal Structure of MsbA from Salmonella typhimurium with ADP Vanadate 3b60 Crystal Structure of MsbA from Salmonella typhimurium with AMPPNP, higher resolution form 3b9p Spastin 3b9q The crystal structure of cpFtsY from Arabidopsis thaliana 3bk7 Structure of the complete ABCE1/RNAase-L Inhibitor protein from Pyrococcus abysii 3c41 ABC protein ArtP in complex with AMP-PNP/Mg2+ 3c4j ABC protein ArtP in complex with ATP-gamma-S 3cf0 Structure of D2 subdomain of P97/VCP in complex with ADP 3cf1 Structure of P97/vcp in complex with ADP/ADP.alfx 3cf2 Structure of P97/vcp in complex with ADP/AMP-PNP 3cf3 Structure of P97/vcp in complex with ADP 3cmt Mechanism of homologous recombination from the RecA-ssDNA/dsDNA structures 3cmu Mechanism of homologous recombination from the RecA-ssDNA/dsDNA structures 3cmv Mechanism of homologous recombination from the RecA-ssDNA/dsDNA structures 3cmw Mechanism of homologous recombination from the RecA-ssDNA/dsDNA structures 3cmx Mechanism of homologous recombination from the RecA-ssDNA/dsDNA structures 3d31 ModBC from Methanosarcina acetivorans 3d8b Crystal structure of human fidgetin-like protein 1 in complex with ADP 3dhw Crystal structure of methionine importer MetNI 3dm5 Structures of SRP54 and SRP19, the two proteins assembling the ribonucleic core of the Signal Recognition Particle from the archaeon Pyrococcus furiosus. 3dm9 Structures and Conformations in Solution of the Signal Recognition Particle Receptor from the archaeon Pyrococcus furiosus 3dmd Structures and Conformations in Solution of the Signal Recognition Particle Receptor from the archaeon Pyrococcus furiosus 3dzd Crystal structure of sigma54 activator NTRC4 in the inactive state 3e1s Structure of an N-terminal truncation of Deinococcus radiodurans RecD2 3e70 Structures and conformations in solution of the Signal Recognition Particle Receptor from the Archaeon Pyrococcus Furiosus 3ec2 Crystal structure of the DnaC helicase loader 3ecc Crystal structure of the DnaC helicase loader in complex with ADP-BeF3 3eie Crystal Structure of S.cerevisiae Vps4 in the SO4-bound state 3eih Crystal structure of S.cerevisiae Vps4 in the presence of ATPgammaS 3etl RadA recombinase from Methanococcus maripaludis in complex with AMPPNP 3ew9 RADA recombinase from METHANOCOCCUS MARIPALUDIS in complex with AMPPNP and potassium ions 3ewa RADA recombinase from METHANOCOCCUS MARIPALUDIS in complex with AMPPNP and ammonium ions 3f9v Crystal Structure Of A Near Full-Length Archaeal MCM: Functional Insights For An AAA+ Hexameric Helicase 3fh6 Crystal structure of the resting state maltose transporter from E. coli 3fks Yeast F1 ATPase in the absence of bound nucleotides 3fvq Crystal structure of the nucleotide binding domain FbpC complexed with ATP 3fyh Recombinase in complex with ADP and metatungstate 3g5u Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding 3g60 Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding 3g61 Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding 3gd7 Crystal structure of human NBD2 complexed with N6-Phenylethyl-ATP (P-ATP) 3gfo Structure of cbiO1 from clostridium perfringens: Part of the ABC transporter complex cbiONQ. 3glf Crystal Structure of the Ecoli Clamp Loader Bound to Primer-Template DNA 3glg Crystal Structure of a Mutant (gammaT157A) E. coli Clamp Loader Bound to Primer-Template DNA 3glh Crystal Structure of the E. coli clamp loader bound to Psi Peptide 3gli Crystal Structure of the E. coli clamp loader bound to Primer-Template DNA and Psi Peptide 3gp8 Crystal structure of the binary complex of RecD2 with DNA 3gpl Crystal structure of the ternary complex of RecD2 with DNA and ADPNP 3h4m AAA ATPase domain of the proteasome- activating nucleotidase 3hr8 Crystal Structure of Thermotoga maritima RecA 3hte Crystal structure of nucleotide-free hexameric ClpX 3hu1 Structure of p97 N-D1 R95G mutant in complex with ATPgS 3hu2 Structure of p97 N-D1 R86A mutant in complex with ATPgS 3hu3 Structure of p97 N-D1 R155H mutant in complex with ATPgS 3hws Crystal structure of nucleotide-bound hexameric ClpX 3i4l Structural characterization for the nucleotide binding ability of subunit A with AMP-PNP of the A1AO ATP synthase 3i72 Structural characterization for the nucleotide binding ability of subunit A with SO4 of the A1AO ATP synthase 3i73 Structural characterization for the nucleotide binding ability of subunit A with ADP of the A1AO ATP synthase 3ice Rho transcription termination factor bound to RNA and ADP-BeF3 3ikj Structural characterization for the nucleotide binding ability of subunit A mutant S238A of the A1AO ATP synthase 3j15 Model of ribosome-bound archaeal Pelota and ABCE1 3j16 Models of ribosome-bound Dom34p and Rli1p and their ribosomal binding partners 3j3r Structural dynamics of the MecA-ClpC complex revealed by cryo-EM 3j3s Structural dynamics of the MecA-ClpC complex revealed by cryo-EM 3j3t Structural dynamics of the MecA-ClpC complex revealed by cryo-EM 3j3u Structural dynamics of the MecA-ClpC complex revealed by cryo-EM 3j5s EttA binds to ribosome exit site and regulates translation by restricting ribosome and tRNA dynamics 3j67 Structural mechanism of the dynein powerstroke (post-powerstroke state) 3j68 Structural mechanism of the dynein powerstroke (pre-powerstroke state) 3j94 3J94 3j95 3J95 3j96 3J96 3j97 3J97 3j98 3J98 3j99 3J99 3j9t 3J9T 3j9u 3J9U 3j9v 3J9V 3ja8 3JA8 3jag 3JAG 3jah 3JAH 3jai 3JAI 3jaj 3JAJ 3jan 3JAN 3jc5 3JC5 3jc6 3JC6 3jc7 3JC7 3jc8 3JC8 3jcm 3JCM 3jco 3JCO 3jcp 3JCP 3jcr 3JCR 3jvu Crystal structure of unliganded P. aeruginosa PilT 3jvv Crystal Structure of P. aeruginosa PilT with bound AMP-PCP 3k1j Crystal structure of Lon protease from Thermococcus onnurineus NA1 3k70 Crystal structure of the complete initiation complex of RecBCD 3kds apo-FtsH crystal structure 3kl4 Recognition of a signal peptide by the signal recognition particle 3l0o Structure of RNA-free Rho transcription termination factor from Thermotoga maritima 3lda Yeast Rad51 H352Y Filament Interface Mutant 3m0e Crystal structure of the ATP-bound state of Walker B mutant of NtrC1 ATPase domain 3m4y Structural characterization of the subunit A mutant P235A of the A-ATP synthase 3m6a Crystal structure of Bacillus subtilis Lon C-terminal domain 3mfy Structural characterization of the subunit A mutant F236A of the A-ATP synthase from Pyrococcus horikoshii 3nbx Crystal structure of E. coli RavA (Regulatory ATPase variant A) in complex with ADP 3ndb Crystal structure of a signal sequence bound to the signal recognition particle 3ng1 N AND GTPASE DOMAINS OF THE SIGNAL SEQUENCE RECOGNITION PROTEIN FFH FROM THERMUS AQUATICUS 3nh6 Nucleotide Binding Domain of human ABCB6 (apo structure) 3nh9 Nucleotide Binding Domain of Human ABCB6 (ATP bound structure) 3nha Nucleotide Binding Domain of Human ABCB6 (ADP Mg bound structure) 3nhb Nucleotide Binding Domain of Human ABCB6 (ADP bound structure) 3ntu RADA RECOMBINASE D302K MUTANT IN COMPLEX with AMP-PNP 3nxs Crystal structure of LAO/AO transport system from Mycobacterium smegmatis bound to GDP 3oaa Structure of the E.coli F1-ATP synthase inhibited by subunit Epsilon 3oe7 Structure of four mutant forms of yeast f1 ATPase: gamma-I270T 3oee Structure of four mutant forms of yeast F1 ATPase: alpha-F405S 3oeh Structure of four mutant forms of yeast F1 ATPase: beta-V279F 3ofn Structure of four mutant forms of yeast F1 ATPase: alpha-N67I 3oiy Helicase domain of reverse gyrase from Thermotoga maritima 3ozx Crystal structure of ABCE1 of Sulfolubus solfataricus (-FeS domain) 3p20 Crystal structure of vanadate bound subunit A of the A1AO ATP synthase 3p4x Helicase domain of reverse gyrase from Thermotoga maritima 3p4y Helicase domain of reverse gyrase from Thermotoga maritima - P2 form 3pfi 2.7 Angstrom resolution crystal structure of a probable holliday junction DNA helicase (ruvB) from Campylobacter jejuni subsp. jejuni NCTC 11168 in complex with adenosine-5'-diphosphate 3pih T. maritima UvrA in complex with fluorescein-modified DNA 3puv Crystal Structure of an outward-facing MBP-Maltose transporter complex bound to ADP-VO4 3puw Crystal Structure of an outward-facing MBP-Maltose transporter complex bound to ADP-AlF4 3pux Crystal Structure of an outward-facing MBP-Maltose transporter complex bound to ADP-BeF3 3puy Crystal Structure of an outward-facing MBP-Maltose transporter complex bound to AMP-PNP after crystal soaking of the pretranslocation state 3puz Crystal Structure of a pre-translocation state MBP-Maltose transporter complex bound to AMP-PNP 3pv0 Crystal Structure of a pre-translocation state MBP-Maltose transporter complex without nucleotide 3pvs Structure and biochemical activities of Escherichia coli MgsA 3pxg Structure of MecA121 and ClpC1-485 complex 3pxi Structure of MecA108:ClpC 3qf4 Crystal structure of a heterodimeric ABC transporter in its inward-facing conformation 3qf7 The Mre11:Rad50 complex forms an ATP dependent molecular clamp in DNA double-strand break repair 3qg5 The Mre11:Rad50 complex forms an ATP dependent molecular clamp in DNA double-strand break repair 3qjy Crystal structure of P-loop G234A mutant of subunit A of the A1AO ATP synthase 3qkt Rad50 ABC-ATPase with adjacent coiled-coil region in complex with AMP-PNP 3qku Mre11 Rad50 binding domain in complex with Rad50 and AMP-PNP 3qmz Crystal structure of the cytoplasmic dynein heavy chain motor domain 3r8f Protein-DNA complex 3rlf Crystal structure of the maltose-binding protein/maltose transporter complex in an outward-facing conformation bound to MgAMPPNP 3sdz Structural characterization of the subunit A mutant F427W of the A-ATP synthase from Pyrococcus horikoshii 3se0 Structural characterization of the subunit A mutant F508W of the A-ATP synthase from Pyrococcus horikoshii 3si7 The crystal structure of the NBD1 domain of the mouse CFTR protein, deltaF508 mutant 3syk Crystal structure of the AAA+ protein CbbX, selenomethionine structure 3syl Crystal structure of the AAA+ protein CbbX, native structure 3tif Dimeric structure of a post-hydrolysis state of the ATP-binding cassette MJ0796 bound to ADP and Pi 3tk1 Crystal structure of a MeaB and Rv1496 ortholog from Mycobacterium thermoresistible bound to GDP 3tui Inward facing conformations of the MetNI methionine ABC transporter: CY5 native crystal form 3tuj Inward facing conformations of the MetNI methionine ABC transporter: DM crystal form 3tuz Inward facing conformations of the MetNI methionine ABC transporter: CY5 SeMet soak crystal form 3u5z Structure of T4 Bacteriophage clamp loader bound to the T4 clamp, primer-template DNA, and ATP analog 3u60 Structure of T4 Bacteriophage Clamp Loader Bound To Open Clamp, DNA and ATP Analog 3u61 Structure of T4 Bacteriophage Clamp Loader Bound To Closed Clamp, DNA and ATP Analog and ADP 3uk6 Crystal Structure of the Tip48 (Tip49b) hexamer 3upu Crystal structure of the T4 Phage SF1B Helicase Dda 3uwx Crystal structure of UvrA-UvrB complex 3ux8 Crystal structure of UvrA 3vfd Human spastin AAA domain 3vkg X-ray structure of an MTBD truncation mutant of dynein motor domain 3vkh X-ray structure of a functional full-length dynein motor domain 3vx4 Crystal Structure of the Nucleotide-Binding Domain of S. mutans ComA, a Bifunctional ATP-binding Cassette Transporter Involved in the Quorum-sensing Pathway 3w34 Ternary complex of Thermus thermophilus HB8 uridine-cytidine kinase with substrates 3w8r Mutant structure of Thermus thermophilus HB8 uridine-cytidine kinase 3whk Crystal structure of PAN-Rpt5C chimera 3whl Crystal structure of Nas2 N-terminal domain complexed with PAN-Rpt5C chimera 3wme Crystal structure of an inward-facing eukaryotic ABC multidrug transporter 3wmf Crystal structure of an inward-facing eukaryotic ABC multitrug transporter G277V/A278V/A279V mutant 3wmg Crystal structure of an inward-facing eukaryotic ABC multidrug transporter G277V/A278V/A279V mutant in complex with an cyclic peptide inhibitor, aCAP 3zd6 Snapshot 1 of RIG-I scanning on RNA duplex 3zd7 Snapshot 3 of RIG-I scanning on RNA duplex 3zdq STRUCTURE OF THE HUMAN MITOCHONDRIAL ABC TRANSPORTER, ABCB10 ( NUCLEOTIDE-FREE FORM) 3zgx Crystal structure of the kleisin-N SMC interface in prokaryotic condensin 3zia The structure of F1-ATPase from Saccharomyces cerevisiae inhibited by its regulatory protein IF1 3zn8 Structural Basis of Signal Sequence Surveillance and Selection by the SRP-SR Complex 3zry Rotor architecture in the F(1)-c(10)-ring complex of the yeast F-ATP synthase 3zuh Negative stain EM Map of the AAA protein CbbX, a red-type Rubisco activase from R. sphaeroides 4a6p RadA C-terminal ATPase domain from Pyrococcus furiosus 4a6x RadA C-terminal ATPase domain from Pyrococcus furiosus bound to ATP 4a82 Fitted model of staphylococcus aureus sav1866 model ABC transporter in the human cystic fibrosis transmembrane conductance regulator volume map EMD-1966. 4ag5 Structure of VirB4 of Thermoanaerobacter pseudethanolicus 4ag6 Structure of VirB4 of Thermoanaerobacter pseudethanolicus 4ai6 Dynein Motor Domain - ADP complex 4ak9 Structure of chloroplast FtsY from Physcomitrella patens 4akg Dynein Motor Domain - ATP complex 4akh Dynein Motor Domain - AMPPNP complex 4aki Dynein Motor Domain - LuAc derivative 4asu F1-ATPase in which all three catalytic sites contain bound nucleotide, with magnesium ion released in the Empty site 4ay2 Capturing 5' tri-phosphorylated RNA duplex by RIG-I 4ayt STRUCTURE OF THE HUMAN MITOCHONDRIAL ABC TRANSPORTER, ABCB10 4ayw STRUCTURE OF THE HUMAN MITOCHONDRIAL ABC TRANSPORTER, ABCB10 (PLATE FORM) 4ayx STRUCTURE OF THE HUMAN MITOCHONDRIAL ABC TRANSPORTER, ABCB10 (ROD FORM B) 4b2i Humanised monomeric RadA in complex with indazole 4b2l Humanised monomeric RadA in complex with L-methylester tryptophan 4b2p RadA C-terminal ATPase domain from Pyrococcus furiosus bound to GTP 4b2q Model of the yeast F1Fo-ATP synthase dimer based on subtomogram average 4b32 Humanised monomeric RadA in complex with napht-1-ol 4b33 Humanised monomeric RadA in complex with napht-2-ol 4b34 Humanised monomeric RadA in complex with 2-amino benzothiazole 4b35 Humanised monomeric RadA in complex with 4-methylester indole 4b3b Humanised monomeric RadA in complex with FHTA tetrapeptide 4b3c Humanised monomeric RadA in complex with 5-hydroxy indole 4b3d Humanised monomeric RadA in complex with 5-methyl indole 4b3f crystal structure of Ighmbp2 helicase 4b3g crystal structure of Ighmbp2 helicase in complex with RNA 4bgd Crystal structure of Brr2 in complex with the Jab1/MPN domain of Prp8 4bpb STRUCTURAL INSIGHTS INTO RNA RECOGNITION BY RIG-I 4bs1 MuB is an AAAplus ATPase that forms helical filaments to control target selection for DNA transposition 4bt0 MuB is an AAAplus ATPase that forms helical filaments to control target selection for DNA transposition 4bt1 MuB is an AAAplus ATPase that forms helical filaments to control target selection for DNA transposition 4c3z 4C3Z 4c7o The structural basis of FtsY recruitment and GTPase activation by SRP RNA 4ciu Crystal structure of E. coli ClpB 4cr2 Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S proteasome 4cr3 Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S proteasome 4cr4 Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S proteasome 4crm 4CRM 4d2q 4D2Q 4d2u 4D2U 4d2x 4D2X 4d6p 4D6P 4d80 4D80 4d81 4D81 4d82 4D82 4dbl Crystal structure of E159Q mutant of BtuCDF 4dc9 Hexameric ring of Methanococcus voltae RadA 4ddt Thermotoga maritima reverse gyrase, C2 FORM 2 4ddu Thermotoga maritima reverse gyrase, C2 FORM 1 4ddv Thermotoga maritima reverse gyrase, triclinic form 4ddw Thermotoga maritima reverse gyrase, c-centered orthorhombic form 4ddx Thermotoga maritima reverse gyrase, primitive monoclinic form 4eiw Whole cytosolic region of atp-dependent metalloprotease FtsH (G399L) 4esv A New Twist on the Translocation Mechanism of Helicases from the Structure of DnaB with its Substrates 4f4c The Crystal Structure of the Multi-Drug Transporter 4f91 Brr2 Helicase Region 4f92 Brr2 Helicase Region S1087L 4f93 Brr2 Helicase Region S1087L, Mg-ATP 4fct Crystal structure of the C-terminal domain of ClpB 4fcv Crystal structure of the C-terminal domain of ClpB 4fcw Crystal structure of the C-terminal domain of ClpB 4fd2 Crystal structure of the C-terminal domain of ClpB 4fdg Crystal Structure of an Archaeal MCM Filament 4fi3 Structure of vitamin B12 transporter BtuCD-F in a nucleotide-bound state 4fin Crystal Structure of EttA (formerly YjjK) - an E. coli ABC-type ATPase 4fwi Crystal structure of the nucleotide-binding domain of a dipeptide ABC transporter 4g1u X-ray structure of the bacterial heme transporter HmuUV from Yersinia pestis 4hlu Structure of the EcfA-A' heterodimer bound to ADP 4hse Crystal structure of ClpB NBD1 in complex with guanidinium chloride and ADP 4huq Crystal Structure of a transporter 4hyy Filament of octameric rings of DMC1 recombinase from Homo sapiens 4hzi Crystal structure of the Leptospira interrogans ATPase subunit of an orphan ABC transporter 4hzu Structure of a bacterial energy-coupling factor transporter 4i34 Crystal Structure of W-W-W ClpX Hexamer 4i4l Crystal Structure of Nucleotide-Bound W-W-W ClpX Hexamer 4i5o Crystal Structure of W-W-R ClpX Hexamer 4i63 Crystal Structure of E-R ClpX Hexamer 4i81 Crystal Structure of ATPgS bound ClpX Hexamer 4i99 Crystal structure of the SmcHead bound to the C-winged helix domain of ScpA 4i9k Crystal structure of symmetric W-W-W ClpX Hexamer 4jbw Crystal structure of E. coli maltose transporter MalFGK2 in complex with its regulatory protein EIIAglc 4k8o 4K8O 4khz Crystal structure of the maltose-binding protein/maltose transporter complex in an pre-translocation conformation bound to maltoheptaose 4ki0 Crystal structure of the maltose-binding protein/maltose transporter complex in an outward-facing conformation bound to maltohexaose 4kit Crystal structure of human Brr2 in complex with the Prp8 Jab1/MPN domain 4kln Structure of p97 N-D1 A232E mutant in complex with ATPgS 4ko8 Structure of p97 N-D1 R155H mutant in complex with ATPgS 4kod Structure of p97 N-D1 R155H mutant in complex with ADP 4ksb Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain 4ksc Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain 4ksd Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain 4ksr Crystal Structure of the Vibrio cholerae ATPase GspE Hexamer 4kss Crystal Structure of Vibrio cholerae ATPase GspsE Hexamer 4l15 Crystal structure of FIGL-1 AAA domain 4l16 Crystal structure of FIGL-1 AAA domain in complex with ADP 4l4u Crystal structure of construct containing A. aeolicus NtrC1 receiver, central and DNA binding domains 4lcb Structure of Vps4 homolog from Acidianus hospitalis 4lgm Crystal Structure of Sulfolobus solfataricus Vps4 4lj4 ClpB NBD2 from T. thermophilus, nucleotide-free 4lj5 ClpB NBD2 from T. thermophilus in complex with ADP 4lj6 ClpB NBD2 from T. thermophilus in complex with AMPPCP 4lj7 ClpB NBD2 K601Q from T. thermophilus in complex with MANT-dADP 4lj8 ClpB NBD2 R621Q from T. thermophilus in complex with ADP 4lj9 ClpB NBD2 R621Q from T. thermophilus in complex with AMPPCP 4lja ClpB NBD2 R621Q from T. thermophilus in complex with AMPPCP and guanidinium chloride 4lsg Structure of Mouse P-Glycoprotein 4ly6 Nucleotide-induced asymmetry within ATPase activator ring drives s54-RNAP interaction and ATP hydrolysis 4lzz Nucleotide-induced asymmetry within atpase activator ring drives s54-RNAP interaction and ATP hydrolysis 4m1m Corrected Structure of Mouse P-glycoprotein 4m2s Corrected Structure of Mouse P-glycoprotein bound to QZ59-RRR 4m2t Corrected Structure of Mouse P-glycoprotein bound to QZ59-SSS 4m4w Mechanistic implications for the bacterial primosome assembly of the structure of a helicase-helicase loader complex 4mki Cobalt transporter ATP-binding subunit 4mrn Structure of a bacterial Atm1-family ABC transporter 4mrp Structure of a bacterial Atm1-family ABC transporter 4mrr Structure of a bacterial Atm1-family ABC transporter 4mrs Structure of a bacterial Atm1-family ABC transporter 4mrv Structure of a bacterial Atm1-family ABC transporter 4myc Structure of the mitochondrial ABC transporter, Atm1 4myh Structure of the Glutathione bound mitochondrial ABC transporter, Atm1 4nch Crystal Structure of Pyrococcus furiosis Rad50 L802W mutation 4nci Crystal Structure of Pyrococcus furiosis Rad50 R805E mutation 4ncj Crystal Structure of Pyrococcus furiosis Rad50 R805E mutation with ADP Beryllium Flouride 4nck Crystal Structure of Pyrococcus furiosis Rad50 R797G mutation 4nh0 4NH0 4nmn Aquifex aeolicus replicative helicase (DnaB) complexed with ADP, at 3.3 resolution 4nph 4NPH 4on9 4ON9 4oqf 4OQF 4p31 Crystal structure of a selenomethionine derivative of E. coli LptB in complex with ADP-Magensium 4p32 Crystal structure of E. coli LptB in complex with ADP-magnesium 4p33 Crystal structure of E. coli LptB-E163Q in complex with ATP-sodium 4pht 4PHT 4pl0 4PL0 4po1 4PO1 4po8 4PO8 4po9 4PO9 4poa 4POA 4ppf 4PPF 4ppg 4PPG 4ppn 4PPN 4ppq 4PPQ 4pqf 4PQF 4pqr 4PQR 4pqy 4PQY 4pr0 4PR0 4psa 4PSA 4psk 4PSK 4psv 4PSV 4ptl 4PTL 4q4a 4Q4A 4q4h 4Q4H 4q4j 4Q4J 4q4l Crystal structure of an ATP synthase subunit beta 1 (F1-B1) from Burkholderia thailandensis 4q7k 4Q7K 4q7l 4Q7L 4q7m 4Q7M 4q9h 4Q9H 4q9i 4Q9I 4q9j 4Q9J 4q9k 4Q9K 4q9l 4Q9L 4qc2 4QC2 4qhs 4QHS 4qht 4QHT 4qkq 4QKQ 4qnm 4QNM 4qnr 4QNR 4qos 4QOS 4r7y 4R7Y 4r9u 4R9U 4rfs 4RFS 4rh7 4RH7 4rvc 4RVC 4ry2 4RY2 4s0f 4S0F 4tqu 4TQU 4tqv 4TQV 4tsf 4TSF 4tt3 4TT3 4twz 4TWZ 4u00 4U00 4u02 4U02 4ue5 4UE5 4upb 4UPB 4uqo 4UQO 4w8f 4W8F 4w9m 4W9M 4wbs 4WBS 4wia 4WIA 4wvy 4WVY 4ww0 4WW0 4ww4 4WW4 4wz6 4WZ6 4xd7 4XD7 4xgc 4XGC 4xgu 4XGU 4xig 4XIG 4xtc 4XTC 4xwk 4XWK 4yer 4YER 4yms 4YMS 4ymt 4YMT 4ymu 4YMU 4ymv 4YMV 4ymw 4YMW 4ypl 4YPL 4ypn 4YPN 4yxw 4YXW 4z1m 4Z1M 4z8x 4Z8X 4zir 4ZIR 4zpx 4ZPX 5a5b 5A5B 5ara 5ARA 5are 5ARE 5arh 5ARH 5ari 5ARI 5awf 5AWF 5awg 5AWG 5b0o 5B0O 5b57 5B57 5b58 5B58 5bq5 5BQ5 5bw9 5BW9 5c18 5C18 5c19 5C19 5c1a 5C1A 5c1b 5C1B 5c73 5C73 5c76 5C76 5c78 5C78 5cdf 5CDF 5d3m 5D3M 5d80 5D80 5da9 5DA9 5dca 5DCA 5dgx 5DGX 5dn6 5DN6 5dny 5DNY 5do7 5DO7 5dyg 5DYG 5dyi 5DYI 5e3h 5E3H 5e7p 5E7P 5eg1 5EG1 5ep0 5EP0 5ep1 5EP1 5ep2 5EP2 5ep3 5EP3 5ep4 5EP4 5eqt 5EQT 5eum 5EUM 5exp 5EXP 5exs 5EXS 5ext 5EXT 5exx 5EXX 5f3w 5F3W 5f98 5F98 5f9f 5F9F 5f9h 5F9H 5fij 5FIJ 5fik 5FIK 5fil 5FIL 5fl3 5FL3 5fl7 5FL7 5fl8 5FL8 5fm6 5FM6 5fm7 5FM7 5fos 5FOS 5fot 5FOT 5fou 5FOU 5fov 5FOV 5fow 5FOW 5fox 5FOX 5fpk 5FPK 5ftb 5FTB 5ftc 5FTC 5ftd 5FTD 5fte 5FTE 5ftf 5FTF 5ftj 5FTJ 5ftk 5FTK 5ftl 5FTL 5ftm 5FTM 5ftn 5FTN 5g4f 5G4F 5g4g 5G4G 5gad 5GAD 5gaf 5GAF 5gag 5GAG 5gah 5GAH 5gan 5GAN 5gao 5GAO 5gap 5GAP 5gjq 5GJQ 5gjr 5GJR 5gm6 5GM6 5hkk 5HKK 5idv 5IDV 5ifs 5IFS 5ifw 5IFW 5ik2 5IK2 5j4h 5J4H 5j4k 5J4K 5j4l 5J4L 5jcs 5JCS 5jec 5JEC 5jed 5JED 5jee 5JEE 5jfg 5JFG 5ji2 5JI2 5jji 5JJI 5jjk 5JJK 5jjl 5JJL 5jrj 5JRJ 5jsz 5JSZ 5jzc 5JZC 5kdd 5KDD 5kne 5KNE 5ko2 5KO2 5kpd 5KPD 5kpi 5KPI 5kpj 5KPJ 5l3q 5L3Q 5l3r 5L3R 5l3s 5L3S 5l3v 5L3V 5l3w 5L3W 5l4g 5L4G 5l8v 5L8V 5lb2 5LB2 5lb4 5LB4 5lbi 5LBI 5ld2 5LD2 5lj5 5LJ5 5lqw 5LQW 5lqx 5LQX 5lqy 5LQY 5lqz 5LQZ 5lw7 5LW7 5lzv 5LZV 5swj 5SWJ 5swl 5SWL 5syp 5SYP 5syr 5SYR 5t0c 5T0C 5t0g 5T0G 5t0h 5T0H 5t0i 5T0I 5t0j 5T0J - Links (links to other resources describing this domain)
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PROSITE AAA INTERPRO IPR003593 PFAM AAA